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Sci Rep:高风险人乳头瘤病毒与乳腺癌

2017-02-28 MedSci MedSci原创

人乳头瘤病毒(HPV)的感染已经牵涉在多种癌症的病因学中。评估乳腺癌(BC)中HPV的存在产生了相当大的争议。到目前为止,大多数研究集中在BC中存在病毒DNA;然而证明HPV在BC侵袭中的作用仍存在巨大的不足。关于此的一些相关研究已经在数个国家中进行,但尚未有关于BC高风险(HR)的HPV的存在和生物活性在英国进行研究。近期,一项发表在杂志Sci Rep上的研究通过使用PCR和Sanger测序方法

人乳头瘤病毒(HPV)的感染已经牵涉在多种癌症的病因学中。


评估乳腺癌(BC)中HPV的存在产生了相当大的争议。到目前为止,大多数研究集中在BC中存在病毒DNA;然而证明HPV在BC侵袭中的作用仍存在巨大的不足。

关于此的一些相关研究已经在数个国家中进行,但尚未有关于BC高风险(HR)的HPV的存在和生物活性在英国进行研究。

近期,一项发表在杂志Sci Rep上的研究通过使用PCR和Sanger测序方法筛选来自英国患者的共110个新鲜乳腺组织标本中存在的12种HR-HPV类型的DNA。使用蛋白质印迹和斑点印迹筛选HPV-DNA阳性的样品的病毒癌蛋白表达。

此项研究数据显示在42%的乳腺组织中存在HR-HPV,其中病毒活性仅在一些侵袭性癌中被证实(5/26)。这一发现表明,病毒癌蛋白在侵袭性病例中的选择性表达可能提供了HR-HPVs在一些类型BC的发展中的作用。

原始出处:
Salman NA, Davies G, et al. Association of High Risk Human Papillomavirus and Breast cancer: A UK based Study. Sci Rep. 2017 Feb 27;7:43591. doi: 10.1038/srep43591.

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    2017-04-06 jyzxjiangqin

    高风险人乳头瘤病毒与乳腺癌。

    0

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    2017-04-02 jyzxjiangqin

    高风险人乳头瘤病毒与乳腺癌。

    0

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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Tue Feb 28 21:30:31 CST 2017, time=2017-02-28, status=1, ipAttribution=)]
    2017-03-23 jyzxjiangqin

    高风险人乳头瘤病毒与乳腺癌。

    0

  5. 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  6. 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    2017-03-01 1e1a50a1m36(暂无匿称)

    人乳头瘤病毒(HPV)的感染已经牵涉在多种癌症的病因学中

    0

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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161026/IMG58107C0F82E499574.jpg, createdBy=00e81970035, createdName=1e15b6fem30(暂无匿称), createdTime=Tue Feb 28 23:43:24 CST 2017, time=2017-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=178250, encodeId=ccc91e825035, content=我去-_-||, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4PNicOvbHfgIficrsEKztlD5yv1UnCFhnFmFU9yv1RHLflMRibWrppbsiccfMB8tT9HCkAr3zL2zVml/0, createdBy=89da1604922, createdName=䖝二, createdTime=Tue Feb 28 22:47:46 CST 2017, time=2017-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=178243, encodeId=27d71e824343, content=学习了,谢谢作者分享!赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Tue Feb 28 21:30:31 CST 2017, time=2017-02-28, status=1, ipAttribution=)]
    2017-03-01 cuiyejia

    谢谢了啊

    0

  8. 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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161026/IMG58107C0F82E499574.jpg, createdBy=00e81970035, createdName=1e15b6fem30(暂无匿称), createdTime=Tue Feb 28 23:43:24 CST 2017, time=2017-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=178250, encodeId=ccc91e825035, content=我去-_-||, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4PNicOvbHfgIficrsEKztlD5yv1UnCFhnFmFU9yv1RHLflMRibWrppbsiccfMB8tT9HCkAr3zL2zVml/0, createdBy=89da1604922, createdName=䖝二, createdTime=Tue Feb 28 22:47:46 CST 2017, time=2017-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=178243, encodeId=27d71e824343, content=学习了,谢谢作者分享!赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Tue Feb 28 21:30:31 CST 2017, time=2017-02-28, status=1, ipAttribution=)]
    2017-02-28 1e15b6fem30(暂无匿称)

    很好的学习资料,谢谢。

    0

  9. 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07:47:00 CST 2017, time=2017-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1443479, encodeId=588b14434e9f6, content=<a href='/topic/show?id=4a65246327c' target=_blank style='color:#2F92EE;'>#人乳头瘤病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24632, encryptionId=4a65246327c, topicName=人乳头瘤病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5fb15077773, createdName=ms3297076796458174, createdTime=Thu Mar 02 11:56:00 CST 2017, time=2017-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=178282, encodeId=28281e828270, content=人乳头瘤病毒(HPV)的感染已经牵涉在多种癌症的病因学中, beContent=null, objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuF63NQckT5BOaic1el7cRelbpr859YXtZQHQSaWnqZCRPOZzDBcjsBNx7AFefLHh1UvMPS4kPP0BG/0, createdBy=47831990981, createdName=1e1a50a1m36(暂无匿称), createdTime=Wed Mar 01 06:18:02 CST 2017, time=2017-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=178272, encodeId=d3fd1e827218, content=谢谢了啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28761705280, createdName=cuiyejia, createdTime=Wed Mar 01 05:21:27 CST 2017, time=2017-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=178253, encodeId=f46f1e8253bc, content=很好的学习资料,谢谢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161026/IMG58107C0F82E499574.jpg, createdBy=00e81970035, createdName=1e15b6fem30(暂无匿称), createdTime=Tue Feb 28 23:43:24 CST 2017, time=2017-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=178250, encodeId=ccc91e825035, content=我去-_-||, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4PNicOvbHfgIficrsEKztlD5yv1UnCFhnFmFU9yv1RHLflMRibWrppbsiccfMB8tT9HCkAr3zL2zVml/0, createdBy=89da1604922, createdName=䖝二, createdTime=Tue Feb 28 22:47:46 CST 2017, time=2017-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=178243, encodeId=27d71e824343, content=学习了,谢谢作者分享!赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Tue Feb 28 21:30:31 CST 2017, time=2017-02-28, status=1, ipAttribution=)]
    2017-02-28 䖝二

    我去-_-||

    0

  10. 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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161026/IMG58107C0F82E499574.jpg, createdBy=00e81970035, createdName=1e15b6fem30(暂无匿称), createdTime=Tue Feb 28 23:43:24 CST 2017, time=2017-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=178250, encodeId=ccc91e825035, content=我去-_-||, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4PNicOvbHfgIficrsEKztlD5yv1UnCFhnFmFU9yv1RHLflMRibWrppbsiccfMB8tT9HCkAr3zL2zVml/0, createdBy=89da1604922, createdName=䖝二, createdTime=Tue Feb 28 22:47:46 CST 2017, time=2017-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=178243, encodeId=27d71e824343, content=学习了,谢谢作者分享!赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Tue Feb 28 21:30:31 CST 2017, time=2017-02-28, status=1, ipAttribution=)]
    2017-02-28 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!赞一个

    0

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近日,北京东方略生物医药科技股份有限公司(ApolloBio)宣布与美国Inovio生物制药公司达成独家合作协议。ApolloBio将出资3500万美元获得Inovio旗下针对人乳头瘤病毒(HPV)的免疫治疗项目——VGX-3100在中国(包括台湾、香港和澳门地区)的研发和商业化权利。VGX-3100是全球首个针对HPV癌前病变的治疗性疫苗,处于临床Ⅲ期,其适应症包括HPV感染引发的癌前病变、异常

Obstet Gynecol:美国年轻女性自我宫颈拭子采集检测HPV患病率分析

在美国HPV疫苗上市六年后,在接种一次或多次疫苗的妇女其与接种疫苗同一类型的HPV患病率有所下降,而与疫苗不属于同一类型HPV的患病率没有变化。此外,在未接种疫苗的妇女中,与HPV疫苗属于同一类型的患病率没有变化。

郎景和院士谈宫颈癌防治

郎景和院士:目前可以通过一种HPV的方法检测女性体内是否携带该病毒。对病毒携带者可以进行密切的监测,对可能发展为子宫颈癌的异常细胞早期进行治疗干预。从全球范围来说,平均每两分钟就有一个妇女因为宫颈癌而死亡。在我国每年大概有1O多万例的宫颈癌的患者,其中至少有一半的女性死于这种疾病。宫颈癌是否可以预防宫颈癌是人类抗癌战斗中最有可能获取胜利的领域。目前我们已了解到某些类型的人乳头状瘤病毒(HPV)

AIM:虽然是轻微细胞学异常,如果HPV 16/18阳性,有必要进行阴道镜检查

近期有研究表明,轻微细胞学异常的女性进行高危HPV检测后,使用HPV 16和18型测试作为第二次筛选试验,可以帮助确定是否有必要进行阴道镜检查。 来自布鲁塞尔公共卫生科学机构的Marc Arbyn博士说:“轻微细胞学异常包括无明确意义的非典型鳞状细胞(ASC-US)或低度鳞状上皮内病变(LSIL),这些情况只会轻度增加宫颈癌风险。由于HPV 16和18型导致了约70%的宫颈癌,如果能将这两个

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