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AP&T: 炎症性肠病导致的疲劳对患者日常活动的影响

2020-12-19 MedSci原创 MedSci原创

以溃疡性结肠炎(UC)和克罗恩病(CD)为主要疾病的炎症性肠病(IBD)是肠道的慢性复发性疾病,会造成包括心理健康和神经精神病学的肠外表现。

溃疡性结肠炎(UC)和克罗恩病(CD)为主要疾病的炎症性肠病(IBD)是肠道的慢性复发性疾病,会造成包括心理健康和神经精神病学的肠外表现。疲劳是患有慢性炎症的患者的常见症状,疲劳和精力不足也是IBD中最普遍的社会心理症状。反过来,疲劳会影响生活质量,正常的社会功能和工作的失能。

 

疲劳很复杂,很难定义。因此,在不同的研究中使用了不一致的疲劳术语和定义,因此很难明确评估其患病率。然而,缓解期IBD患者的约40%存在疲劳症状,活动期IBD患者80%以上存在疲劳。本项研究旨在确定大型IBD人群与一般人群相比疲劳的发生率,危险因素并评估其对日常生活的影响。

研究人员从瑞士炎症性肠病队列研究(SIBDCS)中评估1208名IBD患者以和414名健康进行了比较。严重疲劳定义为视觉模拟量表(VAS-F,范围0-10)得分≥4。次要终点是疲劳严重程度及其对疲劳程度的影响,采用疲劳严重程度量表(FSS),得分≥4表示疲劳。使用多变量方差分析(MANOVA)模型评估了人口统计学,IBD相关和精神病症状的相关性。

总体而言,672名IBD患者(55.6%)表现出明显的疲劳感,而只有145名(35%)对照者出现疲劳感(OR 2.71; 95%CI 2.08-3.54; P  <0.001)。在IBD中,疲劳也会显着影响日常活动(FSS≥4; 405(33.5%)。在MANOVA模型,疲劳水平与女性性别相关联(r= 0.839,95%CI:0.556 - 1.123; P <0.001),诊断时的年龄更年轻(r=-0.031; 95%CI:-0.042- -0.019; P <0.001),更短的病程(r=-0.036; 95%CI:-0.050- -0.022; P <0.001),夜间腹泻(r=0.718; 95%CI:0.295-1.141; P = 0.001),低文化程度(P = 0.034)都与疲劳的发生相关。

 

最后研究人员得出了一个很肯定的结论:与普通人群相比,IBD患者的疲劳更为频繁和严重。

在线使用:疲劳量表-14(FS-14)

原始出处:

Philipp Schreiner. Et al. Fatigue in inflammatory bowel disease and its impact on daily activities. Alimentary Pharmacology and Therapeutics.2020.

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1678963, encodeId=d79416e8963d5, content=<a href='/topic/show?id=6339592095d' target=_blank style='color:#2F92EE;'>#日常活动#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59209, encryptionId=6339592095d, topicName=日常活动)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=474e27711260, createdName=lily1625, createdTime=Wed Feb 17 16:32:58 CST 2021, time=2021-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910423, encodeId=01ce9104234b, content=与普通人群相比,IBD患者的疲劳更为频繁和严重, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Wed Dec 23 19:29:01 CST 2020, time=2020-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=909755, encodeId=c28c909e5535, content=肠胃不舒服,人就没有精神了, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Dec 21 14:37:43 CST 2020, time=2020-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1260928, encodeId=08951260928a4, content=<a href='/topic/show?id=493ee0559a7' target=_blank style='color:#2F92EE;'>#疲劳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70559, encryptionId=493ee0559a7, topicName=疲劳)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=674961, createdName=tamgche, createdTime=Mon Dec 21 02:32:58 CST 2020, time=2020-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547403, encodeId=4543154e40365, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Mon Dec 21 02:32:58 CST 2020, time=2020-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=909456, encodeId=88c690945625, content=如果有机会做临床实验,可以引用这个量表哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201130/be6d5e6ab4a1430aa3d154e79ebfbf74/8e3a836833b041f48050b99f3d0f2022.jpg, createdBy=dafe5224615, createdName=爱读书的大丽子, createdTime=Sat Dec 19 21:55:24 CST 2020, time=2020-12-19, status=1, ipAttribution=)]
    2020-12-23 三生有幸9135

    与普通人群相比,IBD患者的疲劳更为频繁和严重

    0

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    2020-12-21 Jessica

    肠胃不舒服,人就没有精神了

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1678963, encodeId=d79416e8963d5, content=<a href='/topic/show?id=6339592095d' target=_blank style='color:#2F92EE;'>#日常活动#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59209, encryptionId=6339592095d, topicName=日常活动)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=474e27711260, createdName=lily1625, createdTime=Wed Feb 17 16:32:58 CST 2021, time=2021-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910423, encodeId=01ce9104234b, content=与普通人群相比,IBD患者的疲劳更为频繁和严重, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Wed Dec 23 19:29:01 CST 2020, time=2020-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=909755, encodeId=c28c909e5535, content=肠胃不舒服,人就没有精神了, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Dec 21 14:37:43 CST 2020, time=2020-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1260928, encodeId=08951260928a4, content=<a href='/topic/show?id=493ee0559a7' target=_blank style='color:#2F92EE;'>#疲劳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70559, encryptionId=493ee0559a7, topicName=疲劳)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=674961, createdName=tamgche, createdTime=Mon Dec 21 02:32:58 CST 2020, time=2020-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547403, encodeId=4543154e40365, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Mon Dec 21 02:32:58 CST 2020, time=2020-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=909456, encodeId=88c690945625, content=如果有机会做临床实验,可以引用这个量表哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201130/be6d5e6ab4a1430aa3d154e79ebfbf74/8e3a836833b041f48050b99f3d0f2022.jpg, createdBy=dafe5224615, createdName=爱读书的大丽子, createdTime=Sat Dec 19 21:55:24 CST 2020, time=2020-12-19, status=1, ipAttribution=)]
    2020-12-21 tamgche
  5. [GetPortalCommentsPageByObjectIdResponse(id=1678963, encodeId=d79416e8963d5, content=<a href='/topic/show?id=6339592095d' target=_blank style='color:#2F92EE;'>#日常活动#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59209, encryptionId=6339592095d, topicName=日常活动)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=474e27711260, createdName=lily1625, createdTime=Wed Feb 17 16:32:58 CST 2021, time=2021-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910423, encodeId=01ce9104234b, content=与普通人群相比,IBD患者的疲劳更为频繁和严重, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Wed Dec 23 19:29:01 CST 2020, time=2020-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=909755, encodeId=c28c909e5535, content=肠胃不舒服,人就没有精神了, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Dec 21 14:37:43 CST 2020, time=2020-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1260928, encodeId=08951260928a4, content=<a href='/topic/show?id=493ee0559a7' target=_blank style='color:#2F92EE;'>#疲劳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70559, encryptionId=493ee0559a7, topicName=疲劳)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=674961, createdName=tamgche, createdTime=Mon Dec 21 02:32:58 CST 2020, time=2020-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547403, encodeId=4543154e40365, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Mon Dec 21 02:32:58 CST 2020, time=2020-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=909456, encodeId=88c690945625, content=如果有机会做临床实验,可以引用这个量表哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201130/be6d5e6ab4a1430aa3d154e79ebfbf74/8e3a836833b041f48050b99f3d0f2022.jpg, createdBy=dafe5224615, createdName=爱读书的大丽子, createdTime=Sat Dec 19 21:55:24 CST 2020, time=2020-12-19, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1678963, encodeId=d79416e8963d5, content=<a href='/topic/show?id=6339592095d' target=_blank style='color:#2F92EE;'>#日常活动#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59209, encryptionId=6339592095d, topicName=日常活动)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=474e27711260, createdName=lily1625, createdTime=Wed Feb 17 16:32:58 CST 2021, time=2021-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910423, encodeId=01ce9104234b, content=与普通人群相比,IBD患者的疲劳更为频繁和严重, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Wed Dec 23 19:29:01 CST 2020, time=2020-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=909755, encodeId=c28c909e5535, content=肠胃不舒服,人就没有精神了, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Dec 21 14:37:43 CST 2020, time=2020-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1260928, encodeId=08951260928a4, content=<a href='/topic/show?id=493ee0559a7' target=_blank style='color:#2F92EE;'>#疲劳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70559, encryptionId=493ee0559a7, topicName=疲劳)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=674961, createdName=tamgche, createdTime=Mon Dec 21 02:32:58 CST 2020, time=2020-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547403, encodeId=4543154e40365, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Mon Dec 21 02:32:58 CST 2020, time=2020-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=909456, encodeId=88c690945625, content=如果有机会做临床实验,可以引用这个量表哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201130/be6d5e6ab4a1430aa3d154e79ebfbf74/8e3a836833b041f48050b99f3d0f2022.jpg, createdBy=dafe5224615, createdName=爱读书的大丽子, createdTime=Sat Dec 19 21:55:24 CST 2020, time=2020-12-19, status=1, ipAttribution=)]
    2020-12-19 爱读书的大丽子

    如果有机会做临床实验,可以引用这个量表哈哈

    0

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