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Hypertension:动脉硬化跟心衰到底啥关系?

2016-12-27 xing.T MedSci原创

通过cf-PWV来测量的动脉硬化,在对传统的心血管危险因素进行调整后,与心衰或其亚型的风险并不是独立相关的。

动脉硬化程度越高与动脉粥样硬化事件风险增加相关。然而,独立于其他危险因素,其对心力衰竭及其亚型(射血分数保留的心衰和射血分数减少的心衰)风险的影响尚未有研究报道。近日,心血管权威杂志Hypertension上发表一篇研究文章,旨在明确这一问题。

在这项研究中,研究者纳入了健康ABC(健康、衰老和身体成分)研究中的没有发生心衰但在研究之初通过颈动脉股动脉脉搏波传导速度(cf-PWV)测量伴有动脉硬化的参与者(n=2290)。研究人员构建了调整后的Cox比例风险模型来确定的连续的和数据源分类的cf-PWV测量(三分位数)和心衰及其亚型(射血分数保留的心衰 [射血分数>45%]和射血分数减少的心衰[射血分数≤45%])发生率之间的相关性。

经过11.4年的随访,研究者观察到了390次心衰事件(162次为射血分数保留的心衰和145次射血分数减少的心衰事件)。在调整后的分析中,研究者发现调整年龄、性别、种族、平均动脉压和心率后,较高的cf-PWV与更高的心衰风险相关(位于cf-PWV第三组三分位数范围的参与者比上第一组三分位数范围的参与者的风险比[95%的置信区间]为1.35 [1.05-1.73])。


然而,该相关性在额外对其他心血管危险因素进行调整后变得不显著(风险比[95%可信区间]为1.14 [0.88-1.47])。调整潜在的混杂因素后,cf-PWV速度也与射血分数保留的心衰和射血分数减少的心衰的风险不相关(位于cf-PWV第三组三分位数范围的参与者比上第一组三分位数范围的参与者大部分调整后的风险比对于射血分数保留的心衰为1.06 [0.72-1.56];对于射血分数减少的心衰为1.28 [0.83-1.97])。

总之,通过cf-PWV来测量的动脉硬化,在对传统的心血管危险因素进行调整后,与心衰或其亚型的风险并不是独立相关的。

原始出处:

Ambarish Pandey,et al. Arterial Stiffness and Risk of Overall Heart Failure, Heart Failure With Preserved Ejection Fraction, and Heart Failure With Reduced Ejection Fraction. Hypertension. December 19, 2016. 

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    2017-02-22 feather89
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    2016-12-29 1e10c84am36(暂无匿称)

    文章不错,值得学习

    0

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    2016-12-28 1ddc3547m22(暂无匿称)

    有用

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2038569, encodeId=023f203856954, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Sat Sep 23 09:50:00 CST 2017, time=2017-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726256, encodeId=c6f01e262567b, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Wed Feb 22 21:50:00 CST 2017, time=2017-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501103, encodeId=1d7a150110345, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Thu Dec 29 13:50:00 CST 2016, time=2016-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=166547, encodeId=5bbb16654e64, content=文章不错,值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Thu Dec 29 09:59:35 CST 2016, time=2016-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=166388, encodeId=27d61663889d, content=有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85621649328, createdName=1ddc3547m22(暂无匿称), createdTime=Wed Dec 28 20:47:32 CST 2016, time=2016-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=166207, encodeId=9c7f16620ea9, content=明白了,谢谢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Wed Dec 28 06:15:44 CST 2016, time=2016-12-28, status=1, ipAttribution=)]
    2016-12-28 刘煜

    明白了,谢谢。

    0

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