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J Periodontol：替鲁膦酸局部给药对糖尿病大鼠实验性牙周炎的影响

2018-02-24 MedSci MedSci原创

骨吸收糖尿病牙周炎
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已知替鲁膦酸（TIL）具有抗吸收和抗炎特性，但其在牙周炎 - 糖尿病（DM）协会中尚未进行评估。本研究旨在研究局部施用TIL对链脲佐菌素诱导的DM大鼠实验性牙周炎（EP）的影响。

已知替鲁膦酸（TIL）具有抗吸收和抗炎特性，但其在牙周炎 - 糖尿病（DM）协会中尚未进行评估。本研究旨在研究局部施用TIL对链脲佐菌素诱导的DM大鼠实验性牙周炎（EP）的影响。

将32只动物（褐家鼠，Wistar）随机分入4组，DM / C（对照），DM / EP，DM / EP / TIL1和DM / EP / TIL3。在EP组中，结扎下颌第一磨牙。在DM / EP / TIL1组和DM / EP / TIL3组，分别将TIL溶液（分别为1mg / kg和3mg / kg）隔日注射到下颌磨牙的牙龈组织10天，直到安乐死。 使用micro-CT，组织形态计量学，免疫组化（耐酒石酸酸性磷酸酶[TRAP]，核因子-κB配体受体激活剂[RANKL]，骨保护素，切割的半胱氨酸蛋白酶3）和定量逆转录 - 聚合酶链式反应（白细胞介素[IL]-1β，血管内皮生长因子[VEGF]）进行分析。

结果发现，在micro-CT分析中，DM / EP / TIL1和DM / EP / TIL3组抑制了牙槽骨吸收（P <0.05）。DM / EP / TIL3组附着丧失减少（P <0.05）。 TIL组TRAP阳性多核细胞数量减少（P <0.05）。 DM / EP / TIL3组的RANKL免疫标记较低（P <0.05）。 TIL治疗可降低IL-1β的基因表达，DM / EP / TIL3组VEGF表达增加（P <0.05）。

结论：局部施用TIL促进了糖尿病大鼠EP对组织破坏的保护作用，并且3mg / kg TIL的剂量在其抗吸收和抗炎作用方面得到最佳结果。

原始出处：

Nara L.T.Nunes， et al. Effects of local administration of tiludronic acid on experimental periodontitis in diabetic rats. Journal of Periodontology. 2018 January. doi：10.1902/jop.2017.170228

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    2018-06-08 freve

    #实验性牙周炎#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2079569, encodeId=a6b620e95697f, content=<a href='/topic/show?id=21564611139' target=_blank style='color:#2F92EE;'>#实验性牙周炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46111, encryptionId=21564611139, topicName=实验性牙周炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ced3193, createdName=freve, createdTime=Fri Jun 08 12:57:00 CST 2018, time=2018-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2040710, encodeId=4fe32040e1063, content=<a href='/topic/show?id=5887461103d' target=_blank style='color:#2F92EE;'>#实验性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46110, encryptionId=5887461103d, topicName=实验性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3c5e117, createdName=lujian, createdTime=Sun Nov 04 21:57:00 CST 2018, time=2018-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727081, encodeId=84081e27081be, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sun Jun 03 11:57:00 CST 2018, time=2018-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1405813, encodeId=aefc1405813de, content=<a href='/topic/show?id=a5404e589d7' target=_blank style='color:#2F92EE;'>#局部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47589, encryptionId=a5404e589d7, topicName=局部)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d14c2562456, createdName=chg122, createdTime=Mon Feb 26 00:57:00 CST 2018, time=2018-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450768, encodeId=9c771450e689b, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Mon Feb 26 00:57:00 CST 2018, time=2018-02-26, status=1, ipAttribution=)]
    2018-11-04 lujian

    #实验性#

    0

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    2018-06-03 feather89

    #PE#

    0

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    2018-02-26 chg122

    #局部#

    0

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    2018-02-26 liuyong2982

    #牙周#

    0

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