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JAMA子刊:孤独易引发老年痴呆症

2016-11-04 佚名 生物探索

最新研究揭示,老年人感觉孤独,易增加他们患阿尔兹海默症的风险。研究人员发现,大脑内淀粉样蛋白表达量高或者携带APOE4易感基因的老年人,他们感受到的孤独感往往大于其他同龄人。除了有利于早期阿尔兹海默症筛查,这一研究再次提醒我们,要常回家、多陪护老人!近期,来自于哈佛医学院、布莱根妇女医院的Nancy J. Donovan团队发现,老年人感觉孤独与阿尔兹海默症之间有关联。他们在感觉孤独的老年人大脑中

最新研究揭示,老年人感觉孤独,易增加他们患阿尔兹海默症的风险。研究人员发现,大脑内淀粉样蛋白表达量高或者携带APOE4易感基因的老年人,他们感受到的孤独感往往大于其他同龄人。除了有利于早期阿尔兹海默症筛查,这一研究再次提醒我们,要常回家、多陪护老人!
近期,来自于哈佛医学院、布莱根妇女医院的Nancy J. Donovan团队发现,老年人感觉孤独与阿尔兹海默症之间有关联。他们在感觉孤独的老年人大脑中检测到了早期阿尔兹海默症典型病理标志物——淀粉样蛋白。

之前已有研究表明,孤独可能会增加老年人患阿尔兹海默症的风险。而这一篇最新发表在JAMA子刊《JAMA Psychiatry》的学术文章以数据说话,再次佐证了孤独与阿尔兹海默症的关联性。

孤独与阿尔兹海默症

早在2010年,美国退休人员协会(AARP)就进行过一次调研发现:32%的成年人(年龄在60-69岁)和25%的成年人(年龄≥70)感到孤独。备受孤独易引发抑郁症、心脏病和中风。此外,老年人孤独同样容易导致认知能力下降,增加阿尔兹海默症的患病风险。

为了验证两者的关联性,Donovan团队试图验证孤独与大脑中淀粉样蛋白的关系。已有的研究多认为,β-淀粉样蛋白是构成大脑老年斑的主要组成物质,是检测患病程度的重要指标之一,同时也是老年痴呆免疫疗法的关键靶标。

研究团队招募了79名成年人(43位女性、36位男性),他们的平均年龄是76岁,且认知能力正常。他们采用UCLA孤独衡量表评估每个受试对象的孤独感。

UCLA孤独衡量表包含3个问题:

多长时间觉得被遗忘了?多长时间感觉到与社会脱离?多长时间感觉缺乏陪伴?

每个问题分别对应4个标准:1代表“从不”,4代表“经常”。

同时,研究人员借助脑成像技术,检测受试对象大脑中淀粉样蛋白的含量,包括前额颞叶、外侧颞叶和顶叶区。

结果显示:参与者的孤独平均得分是5.3分(满分是12)。但是,相比于大脑淀粉样蛋白表达量低的受试对象,大脑淀粉样蛋白含量高出7.5倍的参与者多感觉到孤独。而且,当受试对象携带APOE4易感基因时,他们的孤独感明显多于未携带者。

当然,这一研究背后仍然存在很多其他干扰因素,包括年龄、性别、焦虑、抑郁以及社会经济地位等等。但是,Donovan团队认为,这些研究结果意味着,孤独感可以作为一个早期阿尔兹海默症检测的指标。这一指标的建立有利于提高老年痴呆症的早期诊断和干预效率。

约翰霍普金斯Bayview医学中心的精神病学和行为科学研究人员Paul B. Rosenberg表示:“最新研究结果有助于推动早期阿尔兹海默症的筛查。未来,基因检测、影像学技术以及情绪、认知评估都可以作为筛查、预估阿尔兹海默症的参考。”

原始出处:
Nancy J. Donovan, MD; Olivia I. Okereke, MD, SM; Patrizia Vannini, PhD; et al.Association of Higher Cortical Amyloid Burden With Loneliness in Cognitively Normal Older Adults.JAMA Psychiatry. November 2, 2016

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    2017-02-02 Boyinsh
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    2016-11-17 指甲娃娃

    我是一个孤独的人,我会早老,我会痴呆啊????

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1836134, encodeId=30e1183613424, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Thu Feb 02 14:46:00 CST 2017, time=2017-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=156380, encodeId=977215638047, content=我是一个孤独的人,我会早老,我会痴呆啊????, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a0d1949546, createdName=指甲娃娃, createdTime=Thu Nov 17 10:58:43 CST 2016, time=2016-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155191, encodeId=226315519105, content=大脑内淀粉样蛋白表达量高或者携带APOE4易感基因的老年人,他们感受到的孤独感往往大于其他同龄人。提醒我们,要常回家、多陪护老人!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Nov 12 08:14:13 CST 2016, time=2016-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=153671, encodeId=e1bc1536e1ce, content=要有意识地排除孤独感, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bd7f1976397, createdName=1e171f9cm65(暂无匿称), createdTime=Sat Nov 05 20:51:31 CST 2016, time=2016-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=153504, encodeId=58ed15350477, content=好好照顾老人,需要我们努力去做, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Nov 05 07:07:56 CST 2016, time=2016-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=153464, encodeId=11821534648b, content=平时多参加活动别让自己静下来, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151226/IMG567EB873985DE3928.jpg, createdBy=ea941622301, createdName=inter158, createdTime=Fri Nov 04 23:46:43 CST 2016, time=2016-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=153336, encodeId=d96715333680, content=多陪陪家人吧~, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Fri Nov 04 12:25:37 CST 2016, time=2016-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=153320, encodeId=3265153320bb, content=关爱老人,多些陪伴, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bb131971301, createdName=飞扬DD, createdTime=Fri Nov 04 11:01:41 CST 2016, time=2016-11-04, status=1, ipAttribution=)]
    2016-11-12 ylzr123

    大脑内淀粉样蛋白表达量高或者携带APOE4易感基因的老年人,他们感受到的孤独感往往大于其他同龄人。提醒我们,要常回家、多陪护老人!

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1836134, encodeId=30e1183613424, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Thu Feb 02 14:46:00 CST 2017, time=2017-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=156380, encodeId=977215638047, content=我是一个孤独的人,我会早老,我会痴呆啊????, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a0d1949546, createdName=指甲娃娃, createdTime=Thu Nov 17 10:58:43 CST 2016, time=2016-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155191, encodeId=226315519105, content=大脑内淀粉样蛋白表达量高或者携带APOE4易感基因的老年人,他们感受到的孤独感往往大于其他同龄人。提醒我们,要常回家、多陪护老人!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Nov 12 08:14:13 CST 2016, time=2016-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=153671, encodeId=e1bc1536e1ce, content=要有意识地排除孤独感, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bd7f1976397, createdName=1e171f9cm65(暂无匿称), createdTime=Sat Nov 05 20:51:31 CST 2016, time=2016-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=153504, encodeId=58ed15350477, content=好好照顾老人,需要我们努力去做, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Nov 05 07:07:56 CST 2016, time=2016-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=153464, encodeId=11821534648b, content=平时多参加活动别让自己静下来, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151226/IMG567EB873985DE3928.jpg, createdBy=ea941622301, createdName=inter158, createdTime=Fri Nov 04 23:46:43 CST 2016, time=2016-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=153336, encodeId=d96715333680, content=多陪陪家人吧~, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Fri Nov 04 12:25:37 CST 2016, time=2016-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=153320, encodeId=3265153320bb, content=关爱老人,多些陪伴, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bb131971301, createdName=飞扬DD, createdTime=Fri Nov 04 11:01:41 CST 2016, time=2016-11-04, status=1, ipAttribution=)]
    2016-11-05 1e171f9cm65(暂无匿称)

    要有意识地排除孤独感

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1836134, encodeId=30e1183613424, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Thu Feb 02 14:46:00 CST 2017, time=2017-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=156380, encodeId=977215638047, content=我是一个孤独的人,我会早老,我会痴呆啊????, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a0d1949546, createdName=指甲娃娃, createdTime=Thu Nov 17 10:58:43 CST 2016, time=2016-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155191, encodeId=226315519105, content=大脑内淀粉样蛋白表达量高或者携带APOE4易感基因的老年人,他们感受到的孤独感往往大于其他同龄人。提醒我们,要常回家、多陪护老人!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Nov 12 08:14:13 CST 2016, time=2016-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=153671, encodeId=e1bc1536e1ce, content=要有意识地排除孤独感, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bd7f1976397, createdName=1e171f9cm65(暂无匿称), createdTime=Sat Nov 05 20:51:31 CST 2016, time=2016-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=153504, encodeId=58ed15350477, content=好好照顾老人,需要我们努力去做, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Nov 05 07:07:56 CST 2016, time=2016-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=153464, encodeId=11821534648b, content=平时多参加活动别让自己静下来, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151226/IMG567EB873985DE3928.jpg, createdBy=ea941622301, createdName=inter158, createdTime=Fri Nov 04 23:46:43 CST 2016, time=2016-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=153336, encodeId=d96715333680, content=多陪陪家人吧~, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Fri Nov 04 12:25:37 CST 2016, time=2016-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=153320, encodeId=3265153320bb, content=关爱老人,多些陪伴, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bb131971301, createdName=飞扬DD, createdTime=Fri Nov 04 11:01:41 CST 2016, time=2016-11-04, status=1, ipAttribution=)]
    2016-11-05 忠诚向上

    好好照顾老人,需要我们努力去做

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1836134, encodeId=30e1183613424, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Thu Feb 02 14:46:00 CST 2017, time=2017-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=156380, encodeId=977215638047, content=我是一个孤独的人,我会早老,我会痴呆啊????, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a0d1949546, createdName=指甲娃娃, createdTime=Thu Nov 17 10:58:43 CST 2016, time=2016-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155191, encodeId=226315519105, content=大脑内淀粉样蛋白表达量高或者携带APOE4易感基因的老年人,他们感受到的孤独感往往大于其他同龄人。提醒我们,要常回家、多陪护老人!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Nov 12 08:14:13 CST 2016, time=2016-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=153671, encodeId=e1bc1536e1ce, content=要有意识地排除孤独感, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bd7f1976397, createdName=1e171f9cm65(暂无匿称), createdTime=Sat Nov 05 20:51:31 CST 2016, time=2016-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=153504, encodeId=58ed15350477, content=好好照顾老人,需要我们努力去做, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Nov 05 07:07:56 CST 2016, time=2016-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=153464, encodeId=11821534648b, content=平时多参加活动别让自己静下来, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151226/IMG567EB873985DE3928.jpg, createdBy=ea941622301, createdName=inter158, createdTime=Fri Nov 04 23:46:43 CST 2016, time=2016-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=153336, encodeId=d96715333680, content=多陪陪家人吧~, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Fri Nov 04 12:25:37 CST 2016, time=2016-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=153320, encodeId=3265153320bb, content=关爱老人,多些陪伴, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bb131971301, createdName=飞扬DD, createdTime=Fri Nov 04 11:01:41 CST 2016, time=2016-11-04, status=1, ipAttribution=)]
    2016-11-04 inter158

    平时多参加活动别让自己静下来

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1836134, encodeId=30e1183613424, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Thu Feb 02 14:46:00 CST 2017, time=2017-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=156380, encodeId=977215638047, content=我是一个孤独的人,我会早老,我会痴呆啊????, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a0d1949546, createdName=指甲娃娃, createdTime=Thu Nov 17 10:58:43 CST 2016, time=2016-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155191, encodeId=226315519105, content=大脑内淀粉样蛋白表达量高或者携带APOE4易感基因的老年人,他们感受到的孤独感往往大于其他同龄人。提醒我们,要常回家、多陪护老人!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Nov 12 08:14:13 CST 2016, time=2016-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=153671, encodeId=e1bc1536e1ce, content=要有意识地排除孤独感, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bd7f1976397, createdName=1e171f9cm65(暂无匿称), createdTime=Sat Nov 05 20:51:31 CST 2016, time=2016-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=153504, encodeId=58ed15350477, content=好好照顾老人,需要我们努力去做, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Nov 05 07:07:56 CST 2016, time=2016-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=153464, encodeId=11821534648b, content=平时多参加活动别让自己静下来, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151226/IMG567EB873985DE3928.jpg, createdBy=ea941622301, createdName=inter158, createdTime=Fri Nov 04 23:46:43 CST 2016, time=2016-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=153336, encodeId=d96715333680, content=多陪陪家人吧~, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Fri Nov 04 12:25:37 CST 2016, time=2016-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=153320, encodeId=3265153320bb, content=关爱老人,多些陪伴, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bb131971301, createdName=飞扬DD, createdTime=Fri Nov 04 11:01:41 CST 2016, time=2016-11-04, status=1, ipAttribution=)]
    2016-11-04 drmike

    多陪陪家人吧~

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1836134, encodeId=30e1183613424, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Thu Feb 02 14:46:00 CST 2017, time=2017-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=156380, encodeId=977215638047, content=我是一个孤独的人,我会早老,我会痴呆啊????, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a0d1949546, createdName=指甲娃娃, createdTime=Thu Nov 17 10:58:43 CST 2016, time=2016-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155191, encodeId=226315519105, content=大脑内淀粉样蛋白表达量高或者携带APOE4易感基因的老年人,他们感受到的孤独感往往大于其他同龄人。提醒我们,要常回家、多陪护老人!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Nov 12 08:14:13 CST 2016, time=2016-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=153671, encodeId=e1bc1536e1ce, content=要有意识地排除孤独感, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bd7f1976397, createdName=1e171f9cm65(暂无匿称), createdTime=Sat Nov 05 20:51:31 CST 2016, time=2016-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=153504, encodeId=58ed15350477, content=好好照顾老人,需要我们努力去做, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Nov 05 07:07:56 CST 2016, time=2016-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=153464, encodeId=11821534648b, content=平时多参加活动别让自己静下来, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151226/IMG567EB873985DE3928.jpg, createdBy=ea941622301, createdName=inter158, createdTime=Fri Nov 04 23:46:43 CST 2016, time=2016-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=153336, encodeId=d96715333680, content=多陪陪家人吧~, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Fri Nov 04 12:25:37 CST 2016, time=2016-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=153320, encodeId=3265153320bb, content=关爱老人,多些陪伴, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bb131971301, createdName=飞扬DD, createdTime=Fri Nov 04 11:01:41 CST 2016, time=2016-11-04, status=1, ipAttribution=)]
    2016-11-04 飞扬DD

    关爱老人,多些陪伴

    0

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来自英国约克大学的一项系统性回顾和荟萃分析显示,与其他公认的危险因素如焦虑或有工作压力等相似,孤独和隔离可增加30% 脑卒中或冠状动脉心脏疾病的发生风险,该研究结果已在线发表于Heart。

JAP:警惕!孤独或增加精神问题风险

发表于国际杂志the Journal of Abnormal Psychology上的一项研究报告中,来自澳大利亚的研究人员通过研究发现,孤独感或许会引发其它心理健康问题,比如抑郁症、社会焦虑及妄想症等。 文章中,研究者对1000多名个体进行为期6个多月的追踪研究,结果发现,那些遭受社会焦虑的个体未来更容易变得孤独;但需要指出的是,这种关联并不等于平等的因果关系,然而这其中还牵涉有其它的因子,

PNAS:为什么孤独的人更易患病?终于有答案了!

尽管既往研究已经证明,孤独会对健康产生负面影响,但人们并不知道这种关联的机制。现在,芝加哥大学心理学教授John T. Cacioppo和他的同事们进行的一项研究表明,孤独可以改变免疫系统细胞,进而增加民众的疾病易感性。这篇研究发表在Proceedings of the National Academy of Sciences。

PNAS:孤独其实是一种病

孤独不仅仅是一种感觉,还会危害人体健康。对于老年人来说,孤独感会使其早逝风险增加14%。那么,孤独是如何造成这种负面影响的呢?芝加哥大学的研究团队日前在美国国家科学院院刊PNAS杂志上发表文章,揭示了孤独触发生理反应并最终让人患病的具体机制。研究人员对人类和恒河猴(一种高度社会化的灵长类动物)进行了孤独研究。他们发现,孤独会使机体产生“战或逃”的压力信号传导,最终影响白细胞的生成。白细胞是一种非常

孤独的人为什么更易生病?

孤独不仅让人感到悲伤,也会抑制自身免疫系统,让你更易生病和早亡。听起来是不是有点恐怖?事实到底如何,让我们来看看科学研究是怎么说的。近日,发表于美国国家科学院院刊(PNAS)上的一项研究提示了孤独是如何最终让人患病的机制。他们发现,孤独会使机体产生“战或逃”的压力信号传导,最终影响白细胞的生成。白细胞是一种非常重要的免疫细胞,帮助机体抵御细菌和病毒的入侵。研究显示交感神经系统活性增加(它对斗争或逃

Psychooncology:癌症患者的孤独感研究

研究者已对老年癌症患者的社会和情感孤独的频率和演变情况(分别与年轻癌症患者和老年非癌症患者相比)进行了研究。目前该研究团队欲探究癌症和年龄相关改变如疲劳、认知功能和功能状态,是否会对“孤独”造成影响。该研究为KLIMOP研究的一部分,包含老年癌症患者 (≥70 岁)、相对年轻的癌症患者 (50-69 岁)、以及老年非癌症患者。研究者采集了参与者的基线资料和随访1年后的资料。根据De Jong-Gi

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