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Doc Ophthalmol:有无视神经炎史的多发性硬化患者的VEP和PERG检测

2017-06-06 cuiguizhong MedSci原创

布达佩斯NyírGyula医院的认知与临床神经科学 Braunitzer G实验室近日在Doc Ophthalmol发表了他们的一项重要工作,提出在没有检测到患有视神经炎的人群中,即使患者没有明显的症状,VEP和PERG都可以用来检测视觉系统的功能障碍。

布达佩斯NyírGyula医院的认知与临床神经科学 Braunitzer G实验室近日在Doc Ophthalmol发表了他们的一项重要工作,提出在没有检测到患有视神经炎的人群中,即使患者没有明显的症状,VEP和PERG都可以用来检测视觉系统的功能障碍。

视觉电生理常规用于检测多发性硬化的视觉并发症,但分析主要集中于视觉诱发电位(VEP),特别是P100组分。他们研究的目标是分析具有良好视力的多发性硬化症(MS)患者中VEPs和视网膜电流图模式(PERG)的成分和波形变化。



他们采用的试验方法如下:分析了85例MS患者的主要VEP和PERG组分,其中38例患者患有视神经炎(ON组),47例没有检测到患有视神经炎(MS组)。47名健康受试者作为对照组,将上述结果与对照组进行比较。

他们发现有趣的现象:相比预期,VEP和PERG两者都发生了较大的改变,而且这些改变跟曾经患有视神经炎(ON组)或者视力下降无关。

因此,他们得到结论:在没有检测到患有视神经炎的人群中,即使患者没有明显的症状,VEP和PERG都可以用来检测视觉系统的功能障碍。虽然PERG不经常用于神经眼科,但结果表明,在没有检测到患有视神经炎的人群中,使用PERG可以为视网膜功能紊乱检测的提供诸多信息。这项研究拓展了人们用于视网膜检测的手段。

原文出处:

Janaky, M., et al., VEP and PERG in patients with multiple sclerosis, with and without a history of optic neuritis. Doc Ophthalmol, 2017. 134(3): p. 185-193.

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    2018-05-18 tomyang86
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    2017-12-17 gj0740
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    2017-09-14 jml2009
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    2017-10-06 feather89
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