Clin Cancer Res：αB-crystallin有望成为乳腺癌脑转移的生物标志物

2013-11-27 MedSci MedSci原创

三阴性乳腺癌是一类预后不佳，易于脑转移的乳腺癌病理类型。在人群队列研究中发现，三阴性乳腺癌组织中αB-crystallin呈现高表达。在体外模型中研究也发现，高倾袭细胞株TNBC也高表达αB-crystallin，如果稳定过表达αB-crystallin，能促进TNBC细胞粘附于脑微动脉内皮细胞，并有助于TNBC透过血脑屏障。反之，如果抑制αB-crystallin表达，则能抑制TNBC的倾袭作用

三阴性乳腺癌是一类预后不佳，易于脑转移的乳腺癌病理类型。在人群队列研究中发现，三阴性乳腺癌组织中αB-crystallin呈现高表达。在体外模型中研究也发现，高倾袭细胞株TNBC也高表达αB-crystallin，如果稳定过表达αB-crystallin，能促进TNBC细胞粘附于脑微动脉内皮细胞，并有助于TNBC透过血脑屏障。反之，如果抑制αB-crystallin表达，则能抑制TNBC的倾袭作用。
因此，研究者认为，αB-crystallin有望成为三阴性乳腺癌脑转移的重要调节物，也可能成为新型的脑转移预测标志物。

原始出处：
Malin D, Strekalova E, Petrovic V, Deal AM, Al Ahmad A, Adamo B, Miller CR, Ugolkov A, Livasy C, Fritchie K, Hamilton EP, Blackwell K, Geradts J, Ewend M, Carey LA, Shusta EV, Anders CK, Cryns VL.αB-crystallin: a Novel Regulator of Breast Cancer Metastasis to the Brain. Clin Cancer Res. 2013 Oct 16.

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2014-03-08 仁者大医

#标志物#

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2013-11-29 膀胱癌

#ALL#

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2013-11-29 zhu_jun9842

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2013-11-29 zhu_jun9842

#生物标志#

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