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Prostate Cancer P D:术前前列腺核磁共振成像对高风险前列腺癌手术治疗的影响研究

2019-09-23 AlexYang MedSci原创

最近,有研究人员评估了手术治疗前进行多参数核磁共振成像(mpMRI)对高风险前列腺癌(HRPC)治疗的手术决定的影响。研究人员对2012年到2015年多个中心的41个连续HRPC案例手术决定进行了调查和询问,并通过国家综合癌症中心网络指南对HRPC进行确定。研究人员对6名专业的泌尿肿瘤专家进行了手术计划调查,并考虑了计划的保留神经和淋巴结清扫程度。研究人员对6名外聘泌尿肿瘤专家进行了2轮的调查。研

最近,有研究人员评估了手术治疗前进行多参数核磁共振成像(mpMRI)对高风险前列腺癌(HRPC)治疗的手术决定的影响。

研究人员对2012年到2015年多个中心的41个连续HRPC案例手术决定进行了调查和询问,并通过国家综合癌症中心网络指南对HRPC进行确定。研究人员对6名专业的泌尿肿瘤专家进行了手术计划调查,并考虑了计划的保留神经和淋巴结清扫程度。研究人员对6名外聘泌尿肿瘤专家进行了2轮的调查。研究发现,所有案例中在mpMRI进行后均至少有一个变化。40(98%)名患者在计划的保留神经程度方面具有变化:即32%的患者接受了更广泛的切除,24%的患者保留了更多的神经。在mpMRI进行之后,正确的手术计划改变在右侧占比49%,在左侧占比51%,减少了阳性手术切缘的可能。另外,从标准的淋巴结清扫到扩大的淋巴结清扫占比17%。

最后,研究人员指出,尽管mpMRI并没有包含在HRPC术前计划指南,该技术的使用也许对手术计划、癌症控制和生活质量产生影响。

原始出处:

Janet Baack Kukreja, Tharakeswara K. Bathala, Chad A. Reichard et al. Impact of preoperative prostate magnetic resonance imaging on the surgical management of high-risk prostate cancer. Prostate Cancer P D. 09 Sep 2019

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  5. [GetPortalCommentsPageByObjectIdResponse(id=1862106, encodeId=c58218621060a, content=<a href='/topic/show?id=a374102813a1' target=_blank style='color:#2F92EE;'>#高风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102813, encryptionId=a374102813a1, topicName=高风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f5e185, createdName=zlawrance, createdTime=Fri Mar 06 01:48:00 CST 2020, time=2020-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1791587, encodeId=52401e91587df, content=<a href='/topic/show?id=b77f14e4541' target=_blank style='color:#2F92EE;'>#Prostate Ca#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14745, encryptionId=b77f14e4541, topicName=Prostate Ca)], attachment=null, authenticateStatus=null, createdAvatar=, 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  6. 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encodeId=0bf83e311464, content=学习了,很有用,不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Tue Sep 24 00:01:33 CST 2019, time=2019-09-24, status=1, ipAttribution=)]
    2019-09-25 lsndxfj
  7. 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encodeId=0bf83e311464, content=学习了,很有用,不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Tue Sep 24 00:01:33 CST 2019, time=2019-09-24, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1862106, encodeId=c58218621060a, content=<a href='/topic/show?id=a374102813a1' target=_blank style='color:#2F92EE;'>#高风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102813, encryptionId=a374102813a1, topicName=高风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f5e185, createdName=zlawrance, createdTime=Fri Mar 06 01:48:00 CST 2020, time=2020-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1791587, encodeId=52401e91587df, content=<a href='/topic/show?id=b77f14e4541' target=_blank style='color:#2F92EE;'>#Prostate Ca#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14745, encryptionId=b77f14e4541, topicName=Prostate Ca)], attachment=null, authenticateStatus=null, createdAvatar=, 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encodeId=0bf83e311464, content=学习了,很有用,不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Tue Sep 24 00:01:33 CST 2019, time=2019-09-24, status=1, ipAttribution=)]
    2019-09-25 sunylz
  9. 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encodeId=0bf83e311464, content=学习了,很有用,不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Tue Sep 24 00:01:33 CST 2019, time=2019-09-24, status=1, ipAttribution=)]
    2019-09-24 misszhang

    前列腺癌相关研究,学习了,谢谢梅斯

    0

  10. 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encodeId=0bf83e311464, content=学习了,很有用,不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Tue Sep 24 00:01:33 CST 2019, time=2019-09-24, status=1, ipAttribution=)]
    2019-09-24 飛歌

    学习了,很有用,不错

    0

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P53是一个肿瘤抑制子,能够阻止癌症起始和恶化,且p53基因的变异能够引起肿瘤抑制子蛋白功能的丧失。肿瘤细胞中突变p53蛋白能够形成堆积物从而与野生型p53蛋白产生显隐性效应,引起p53肿瘤抑制作用的丧失而获得新的致瘤功能。p53变异在原发性前列腺癌(PCa)的致病机理过程中具有作用,并且总能够在复发性和转移性疾病中检测到。因此,靶向突变p53可能成为晚期PCa的一种可选择的治疗策略。研究人员利用

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活性氧(ROS)和ROS诱导的氧化应激与前列腺癌(PCa)发展和肿瘤去势抵抗性的恶化相关。该过程部分的是通过雄激素受体(AR)信号的激活。然而,ROS激活AR的潜在机制仍旧不清楚。最近,有研究人员报道了包含硫氧还蛋白结构域蛋白9(TXNDC9)是ROS激活AR信号的一个重要的调节因子。TXNDC9的表达可以由ROS诱导上调,TXNDC9表达的上调与晚期临床阶段有关。TXNDC9还能促进PCa细胞生

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