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Lancet Gastroen Hepatol:亚太地区幽门螺杆菌原发耐药性研究

2017-08-04 zhangfan MedSci原创

研究发现亚太地区,幽门螺旋杆菌对各种抗生素的耐药性差异较大,因此,各国应采取符合本国国情的治疗策略

近日研究人员对亚太地区原发性幽门螺旋杆菌耐药性的趋势和区域差异以及耐药性与一线根除的关系进行了评估。

这是一项系统综述与荟萃分析,研究人员对1990-2016的相关资料进行了收集,原发性抗生素耐药性分析包括观察性研究和随机对照试验,一线治疗效果分析仅包含随机对照试验。采用随机效应模型用于整个地区的耐药性变化的荟萃分析,对具体的国家以及时间段进行亚组分析以考察原发性耐药率和特定国家的一线根除率。

来自24个国家的176篇相关文献纳入耐药性分析研究。总的幽门螺旋杆菌耐药率如下:克拉霉素17% (95% CI 15-18);甲硝哒唑44% (95% CI 39-48);左氧氟沙星18% (95% CI 15-22);羟氨苄青霉素3% (95% CI 2-5);四环素4% (95% CI 2-5)。研究期间,克拉霉素和左氧氟沙星的耐药率显著上升,而其他抗生素的耐药性保持稳定。来自16个国家的170篇研究纳入一线疗效分析,研究发现,亚太地区含克拉霉素的一线幽门螺旋杆菌治疗效果不理想(有效率<80%),绝大部分地区克拉霉素耐药率高于20%。

研究发现亚太地区,幽门螺旋杆菌对各种抗生素的耐药性差异较大,因此,各国应采取符合本国国情的治疗策略。

原始出处:


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    2018-04-23 kcb069
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    2018-01-14 许安
  4. 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GetPortalCommentsPageByObjectIdResponse(id=1543334, encodeId=55b715433340b, content=<a href='/topic/show?id=0dc224246b2' target=_blank style='color:#2F92EE;'>#亚太地区#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24246, encryptionId=0dc224246b2, topicName=亚太地区)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=539b13566968, createdName=ms5439512287675881, createdTime=Sat Aug 05 23:56:00 CST 2017, time=2017-08-05, status=1, ipAttribution=)]
    2017-09-14 jyzxjiangqin

    亚太地区幽门螺杆菌原发耐药性研究.

    0

  5. 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  6. 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    2017-09-03 jyzxjiangqin

    亚太地区幽门螺杆菌原发耐药研究.

    0

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    2017-11-26 howi
  8. 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    2017-08-06 ylzr123

    不错的方式,努力学习,刻苦专研,不断总结出来新经验。给点个赞!

    0

  9. 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    2017-08-05 gwc384
  10. 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全球超半数人口感染了幽门螺旋杆菌,根除幽门螺旋杆菌的形式仍然严峻

LANCET:消化性溃疡的现状

近年,幽门螺杆菌感染的迅速下降以及有效抗分泌药物的广泛使用使得消化性溃疡已经不像二十年前那样普遍了。然而,对消化性溃疡的管理却变得比以往更具挑战性。这是因为在世界范围内,抗菌素耐药性的增加以及在老龄化人群中广泛使用复杂的抗血栓治疗药物。此外,与幽门螺杆菌感染无关的消化性溃疡或者因使用非甾体抗炎药物导致的消化性溃疡,也增加了诊断和治疗的挑战性。了解消化性溃疡致病机制的相关最新进展,掌握针对幽门螺杆菌

Am J Gastroenterol:ACG / CAG联合消化不良诊断和治疗指南

美国胃肠病学会(ACG)和加拿大胃肠病学协会(CAG)更新了ACG / CAG联合消化不良诊断和治疗指南

Intern Med J:幽门螺杆菌感染或增加胃肠道癌症化疗诱导的呕吐

据统计,全球约有44亿幽门螺杆菌感染者,在中国这一数字更是达到了令人吃惊的7.68亿,达到50%!恶心和呕吐为化疗最常见的不良反应。2017年7月,发表在《Intern Med J》的一项研究表明,幽门螺杆菌感染或增加胃肠道癌症化疗诱导的呕吐。

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