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Radiology:非强化电影MR图像在亚急性和慢性心肌梗死瘢痕纹理分析准确性的价值。

2017-08-30 shaosai MedSci原创

心肌梗死又叫心肌梗塞,心肌梗塞(myocardialinfarction, MI)是冠状动脉闭塞,血流中断,使部分心肌因严重的持久性缺血而发生局部坏死。临床上有剧烈而较持久的胸骨后疼痛,发热、白细胞增多、红细胞沉降率加快,血清心肌酶活力增高及进行性心电图变化,可发生心律失常、休克或心力衰竭。本研究旨在测试利用非强化电影心脏磁共振(MR)纹理分析(TA)诊断亚急性和慢性心肌梗死的价值,并将结果发表在

心肌梗死又叫心肌梗塞,心肌梗塞(myocardialinfarction, MI)是冠状动脉闭塞,血流中断,使部分心肌因严重的持久性缺血而发生局部坏死。临床上有剧烈而较持久的胸骨后疼痛,发热、白细胞增多、红细胞沉降率加快,血清心肌酶活力增高及进行性心电图变化,可发生心律失常、休克或心力衰竭。本研究旨在测试利用非强化电影心脏磁共振(MR)纹理分析(TA)诊断亚急性和慢性心肌梗死的价值,并将结果发表在Radiology上。

本研究回顾性分析了120例行心脏MR检查的患者,包括亚急性和慢性大面积透壁性梗死(延迟期(LGE)图像上强化体积比例>20%, n = 72)和小灶性透壁性梗死(强化体积比例≤20%, n = 48);并有6例正常心脏MR图像作为对照组。利用免费软件,在收缩末期的电影图像上由两名观察者独立采用盲法对左心室感兴趣区进行TA。以LGE成像作为参考标准,利用基于可重复性的逐步降维法和纹理特征选择、机器学习和相关性分析来选择特征,在非强化电影MR图像上诊断MI。

结果为,在各亚组(Teta1,Perc.01,Variance,WavEnHH.s-3和S(5,5)SumEntrp(在大面积MI:所有P< .001;在小面积MI:Teta1 和Perc.01, P < .001; Variance, P = .026; WavEnHH.s-3, P = .007; S[5,5]SumEntrp, P = .045)),共有5种独立纹理特征能够在电影MR图像上鉴别缺血性心肌和正常心肌。多元Logistic回归模型表明结合特征Teta1和Perc.01在电影MR图像上诊断大面积MI和小面积MI具有最高的准确率,曲线下面积分别为0.93、0.92。

本概念研究研究表明,非强化电影MR图像的TA对诊断亚急性和慢性MI具有较高的准确率。

原始出处:

Baessler B, Mannil M, Oebel S, Fuentes DT, et al,Subacute and Chronic Left Ventricular Myocardial Scar: Accuracy of Texture Analysis on Nonenhanced Cine MR Images. Radiology. 2017.DOI: 10.1148/radiol.2017170213

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