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Circulation:D-二聚体水平可预测冠心病患者的长期死亡率、心血管事件和癌症发病率

2018-08-17 MedSci MedSci原创

D-二聚体是交联纤维蛋白的降解产物,是高凝和血栓形成的标志物。D-二聚体中度升高与血管疾病患者的动静脉事件的风险相关。现研究人员对D-二聚体水平用于预测长期血管预后、特殊原因的死亡率以及新发癌症的作用进行评估。LIPID试验,将心肌梗死或不稳定心绞痛发生后5-38个月的患者随机分至普伐他汀(40mg/d)或安慰剂组。于起始和1年时检测D-二聚体水平。中位随访6.0年,总起来16年。7863位患者按

D-二聚体是交联纤维蛋白的降解产物,是高凝和血栓形成的标志物。D-二聚体中度升高与血管疾病患者的动静脉事件的风险相关。现研究人员对D-二聚体水平用于预测长期血管预后、特殊原因的死亡率以及新发癌症的作用进行评估。

LIPID试验,将心肌梗死或不稳定心绞痛发生后5-38个月的患者随机分至普伐他汀(40mg/d)或安慰剂组。于起始和1年时检测D-二聚体水平。中位随访6.0年,总起来16年。

7863位患者按其起始D-二聚体水平分成四组(≤112、112–173、173–273、>273ng/mL)。高D-二聚体水平与年老、女性、高血压史、肾功能差和B型钠尿肽、高敏C反应蛋白和敏感肌钙蛋白I水平升高相关(p均<0.0001)。在随访前6年,根据多达30个额外风险因素校正后,高D-二聚体水平与主冠脉事件(>273ng/mL vs ≤112ng/mL:HR 1.45,95% CI 1.21-1.74)、冠心病(CVD)事件(HR 1.45,95% CI 1.23-1.71)和静脉血栓形成(HR 4.03,95% CI 2.31-7.03)风险显著增加相关(p均<0.001)。在整体的16年,高D-二聚体水平是全因死亡率(HR 1.59)、CVD死亡率(HR 1.61)、癌死亡率(HR 1.54)和非CVD非癌死亡率(HR 1.57)的独立的预测因子(p均<0.001)。高D-二聚体水平还是癌症发病率增高的独立预测因子(HR 1.16,p=0.02)。

D-二聚体水平可预测动静脉事件的长期风险、CVD死亡率和非CVD非癌死亡率,并独立于其他风险因素。D-二聚体还是癌症发病率和死亡率的重要预测因子。

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    2018-10-01 hxj0117
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    2018-08-22 三不猴

    谢谢分享

    0

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    2018-08-17 邓启付

    D-2聚体还是癌症发病率和死亡率的重要预测因子,学习了!

    0

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