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Clin Oral Invest: 摄入鼠李糖乳杆菌可预防念珠菌病的发生

2018-08-21 MedSci MedSci原创

本研究旨在探讨鼠李糖乳杆菌的摄入对念珠菌病和细胞因子释放的影响。

本研究旨在探讨鼠李糖乳杆菌的摄入对念珠菌病和细胞因子释放的影响。

将念珠菌悬浮液接种到免疫抑制小鼠的口腔中以诱导念珠菌病。将动物分成实验组和对照组。实验组:念珠菌病,不摄入益生菌 (F),念珠菌接种期间摄入益生菌(FP),以及接种念珠菌(FPP)前14天摄入益生菌;和对照组:(C),(CP)和(CPP)分别以与F,FP和FPP相同的方式分别用益生菌摄入诱导念珠菌病。之后,从口腔收集样本用于酵母计数,并且在安乐死之后,取出动物的舌头用于组织学分析。收集血清样品用于分析IL-1β,TNF-α,INF-γ,IL-1 2,IL-4和IL-10。

结果:FP组念珠菌计数较低, FPP组中几乎未检测到念珠菌。组织中,FPP组的真菌计数显着降低,其次是FP组。与F组相比,消耗益生菌的组也具有较低的组织学和炎性浸润。细胞因子分析显示所有组中TNF-α,IL-12,IL-4和IL-10的浓度均低,并且它们之间没有统计学差异。消耗益生菌的实验组检测到的IL-6更多,细胞因子水平显着低。

结果表明,鼠李糖乳杆菌摄入,可以避免或减少免疫抑制小鼠念珠菌病的发展。

原始出处:

Mariella Vieira Pereira Leao, et al. Lactobacillus rhamnosus intake can prevent the development of Candidiasis. Clinical Oral Investigations. 2018 September. doi: 1007/s00784-018-2347-8

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    2019-07-24 小几洁
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    2018-08-22 123935f8m05暂无昵称

    为什么FPP组的益生菌引入时间设置是14天前呢

    0

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