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15年来中国人群高胆固醇患病率增加1.9倍,达到14.4%

2015-02-17 王薇,刘静,王淼 中华心血管病杂志

首都医科大学附属北京安贞医院赵冬教授等分析发现,1992-2007年15年间,我国居民血清总胆固醇水平明显升高。高胆固醇患病率从4.9%升高至14.4%,增加了1.9倍。男性高胆固醇患病率从5.1%升至8.5%,女性从4.9%升至20.0%。 作者在讨论中指出,我国人群胆固醇升高是导致冠心病死亡率增加的重要原因,胆固醇水平的增高预示着未来心血管病疾病负担的增加,“应加强全民健康生活方式宣教,

首都医科大学附属北京安贞医院赵冬教授等分析发现,1992-2007年15年间,我国居民血清总胆固醇水平明显升高。高胆固醇患病率从4.9%升高至14.4%,增加了1.9倍。男性高胆固醇患病率从5.1%升至8.5%,女性从4.9%升至20.0%。

作者在讨论中指出,我国人群胆固醇升高是导致冠心病死亡率增加的重要原因,胆固醇水平的增高预示着未来心血管病疾病负担的增加,“应加强全民健康生活方式宣教,尤其是在中青年和广大的农村地区。遏制并进一步逆转全人群胆固醇水平的上升趋势,是减少全民心血管疾病负担的重要策略。”

研究发现,在1992-2007年间,平均总胆固醇水平男性从4.65 mmol/L增至4.96 mmol/L,女性从4.40 mmol/L增至5.35 mmol/L。随时间推移,男性和女性总胆固醇水平分布曲线均向右侧更高水平移动(图1)。



图1 我国居民男性和女性胆固醇水平分布曲线均向更高水平移动


而著名的弗莱明翰心脏研究发现,随时间的推移,基线总胆固醇水平低者呈上升变化,而基线总胆固醇水平高者呈降低变化,该现象被称为“向均值回归”。看来,我国居民没有发生这一现象。

从性别角度看,女性35~44岁年龄段人群平均总胆固醇水平增加值最大,为0.95 mmol/L。从不同地区的角度看,总胆固醇平均值最低的农村人群平均总胆固醇水平增加值最大,为0.88 mmol/L。

作者认为,基线胆固醇正常者对患病人数的增加贡献大,“进一步证实联合采用高危策略和全人群策略,对有效降低国人高胆固醇血症患病率的重要性和必要性。”

研究者于1992年在多省市35~64岁人群中进行基线危险因素调查,并建立心血管病研究队列;2007年在该队列人群中再次组织危险因素调查。2次调查资料均完整的调查对象共5740名,对其血清总胆固醇进行分析。高胆固醇血症组定义为≥6.22 mmol/L。

来源:王薇,刘静,王淼, 等. 1992至2007年多省市队列人群总胆固醇水平的变化特点. 中华心血管病杂志, 2014;42:230-235.

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  1. [GetPortalCommentsPageByObjectIdResponse(id=16880, encodeId=3f3a168803d, content=不错的文章,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=167, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f2fb1607679, createdName=orthoW, createdTime=Tue Feb 24 11:19:00 CST 2015, time=2015-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1250412, encodeId=567e12504120f, content=<a href='/topic/show?id=7d6f52988e1' target=_blank style='color:#2F92EE;'>#患病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52988, encryptionId=7d6f52988e1, topicName=患病率)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Thu Feb 19 13:15:00 CST 2015, time=2015-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16380, encodeId=1fa7163808b, content=请注明引用出处,好吗。, beContent=null, objectType=article, channel=null, level=null, likeNumber=148, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=101.26.186.**, createdTime=Wed Feb 18 17:43:00 CST 2015, time=2015-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16346, encodeId=3234163461a, content=预防…饮食…锻炼, beContent=null, objectType=article, channel=null, level=null, likeNumber=180, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200609/ef6a57dbe7f1489dad7446b7c5217858/d5e4fe65996c4446a029b0f5d056abb1.jpg, createdBy=6b011518214, createdName=午夜星河, createdTime=Wed Feb 18 06:59:00 CST 2015, time=2015-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16335, encodeId=9ca4163354d, content=而著名的弗莱明翰心脏研究发现,随时间的推移,基线总胆固醇水平低者呈上升变化,而基线总胆固醇水平高者呈降低变化,该现象被称为“向均值回归”。看来,我国居民没有发生这一现象。 说明人家重视预防!, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Tue Feb 17 23:10:00 CST 2015, time=2015-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16320, encodeId=3f761632023, content=到底要不要减少胆固醇摄入?, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=49.4.167.**, createdTime=Tue Feb 17 22:55:00 CST 2015, time=2015-02-17, status=1, ipAttribution=)]
    2015-02-24 orthoW

    不错的文章,学习了

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=16880, encodeId=3f3a168803d, content=不错的文章,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=167, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f2fb1607679, createdName=orthoW, createdTime=Tue Feb 24 11:19:00 CST 2015, time=2015-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1250412, encodeId=567e12504120f, content=<a href='/topic/show?id=7d6f52988e1' target=_blank style='color:#2F92EE;'>#患病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52988, encryptionId=7d6f52988e1, topicName=患病率)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Thu Feb 19 13:15:00 CST 2015, time=2015-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16380, encodeId=1fa7163808b, content=请注明引用出处,好吗。, beContent=null, objectType=article, channel=null, level=null, likeNumber=148, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=101.26.186.**, createdTime=Wed Feb 18 17:43:00 CST 2015, time=2015-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16346, encodeId=3234163461a, content=预防…饮食…锻炼, beContent=null, objectType=article, channel=null, level=null, likeNumber=180, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200609/ef6a57dbe7f1489dad7446b7c5217858/d5e4fe65996c4446a029b0f5d056abb1.jpg, createdBy=6b011518214, createdName=午夜星河, createdTime=Wed Feb 18 06:59:00 CST 2015, time=2015-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16335, encodeId=9ca4163354d, content=而著名的弗莱明翰心脏研究发现,随时间的推移,基线总胆固醇水平低者呈上升变化,而基线总胆固醇水平高者呈降低变化,该现象被称为“向均值回归”。看来,我国居民没有发生这一现象。 说明人家重视预防!, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Tue Feb 17 23:10:00 CST 2015, time=2015-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16320, encodeId=3f761632023, content=到底要不要减少胆固醇摄入?, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=49.4.167.**, createdTime=Tue Feb 17 22:55:00 CST 2015, time=2015-02-17, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=16880, encodeId=3f3a168803d, content=不错的文章,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=167, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f2fb1607679, createdName=orthoW, createdTime=Tue Feb 24 11:19:00 CST 2015, time=2015-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1250412, encodeId=567e12504120f, content=<a href='/topic/show?id=7d6f52988e1' target=_blank style='color:#2F92EE;'>#患病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52988, encryptionId=7d6f52988e1, topicName=患病率)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Thu Feb 19 13:15:00 CST 2015, time=2015-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16380, encodeId=1fa7163808b, content=请注明引用出处,好吗。, beContent=null, objectType=article, channel=null, level=null, likeNumber=148, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=101.26.186.**, createdTime=Wed Feb 18 17:43:00 CST 2015, time=2015-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16346, encodeId=3234163461a, content=预防…饮食…锻炼, beContent=null, objectType=article, channel=null, level=null, likeNumber=180, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200609/ef6a57dbe7f1489dad7446b7c5217858/d5e4fe65996c4446a029b0f5d056abb1.jpg, createdBy=6b011518214, createdName=午夜星河, createdTime=Wed Feb 18 06:59:00 CST 2015, time=2015-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16335, encodeId=9ca4163354d, content=而著名的弗莱明翰心脏研究发现,随时间的推移,基线总胆固醇水平低者呈上升变化,而基线总胆固醇水平高者呈降低变化,该现象被称为“向均值回归”。看来,我国居民没有发生这一现象。 说明人家重视预防!, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Tue Feb 17 23:10:00 CST 2015, time=2015-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16320, encodeId=3f761632023, content=到底要不要减少胆固醇摄入?, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=49.4.167.**, createdTime=Tue Feb 17 22:55:00 CST 2015, time=2015-02-17, status=1, ipAttribution=)]
    2015-02-18 101.26.186.**

    请注明引用出处,好吗。

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=16880, encodeId=3f3a168803d, content=不错的文章,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=167, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f2fb1607679, createdName=orthoW, createdTime=Tue Feb 24 11:19:00 CST 2015, time=2015-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1250412, encodeId=567e12504120f, content=<a href='/topic/show?id=7d6f52988e1' target=_blank style='color:#2F92EE;'>#患病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52988, encryptionId=7d6f52988e1, topicName=患病率)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Thu Feb 19 13:15:00 CST 2015, time=2015-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16380, encodeId=1fa7163808b, content=请注明引用出处,好吗。, beContent=null, objectType=article, channel=null, level=null, likeNumber=148, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=101.26.186.**, createdTime=Wed Feb 18 17:43:00 CST 2015, time=2015-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16346, encodeId=3234163461a, content=预防…饮食…锻炼, beContent=null, objectType=article, channel=null, level=null, likeNumber=180, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200609/ef6a57dbe7f1489dad7446b7c5217858/d5e4fe65996c4446a029b0f5d056abb1.jpg, createdBy=6b011518214, createdName=午夜星河, createdTime=Wed Feb 18 06:59:00 CST 2015, time=2015-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16335, encodeId=9ca4163354d, content=而著名的弗莱明翰心脏研究发现,随时间的推移,基线总胆固醇水平低者呈上升变化,而基线总胆固醇水平高者呈降低变化,该现象被称为“向均值回归”。看来,我国居民没有发生这一现象。 说明人家重视预防!, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Tue Feb 17 23:10:00 CST 2015, time=2015-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16320, encodeId=3f761632023, content=到底要不要减少胆固醇摄入?, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=49.4.167.**, createdTime=Tue Feb 17 22:55:00 CST 2015, time=2015-02-17, status=1, ipAttribution=)]
    2015-02-18 午夜星河

    预防…饮食…锻炼

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=16880, encodeId=3f3a168803d, content=不错的文章,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=167, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f2fb1607679, createdName=orthoW, createdTime=Tue Feb 24 11:19:00 CST 2015, time=2015-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1250412, encodeId=567e12504120f, content=<a href='/topic/show?id=7d6f52988e1' target=_blank style='color:#2F92EE;'>#患病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52988, encryptionId=7d6f52988e1, topicName=患病率)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Thu Feb 19 13:15:00 CST 2015, time=2015-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16380, encodeId=1fa7163808b, content=请注明引用出处,好吗。, beContent=null, objectType=article, channel=null, level=null, likeNumber=148, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=101.26.186.**, createdTime=Wed Feb 18 17:43:00 CST 2015, time=2015-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16346, encodeId=3234163461a, content=预防…饮食…锻炼, beContent=null, objectType=article, channel=null, level=null, likeNumber=180, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200609/ef6a57dbe7f1489dad7446b7c5217858/d5e4fe65996c4446a029b0f5d056abb1.jpg, createdBy=6b011518214, createdName=午夜星河, createdTime=Wed Feb 18 06:59:00 CST 2015, time=2015-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16335, encodeId=9ca4163354d, content=而著名的弗莱明翰心脏研究发现,随时间的推移,基线总胆固醇水平低者呈上升变化,而基线总胆固醇水平高者呈降低变化,该现象被称为“向均值回归”。看来,我国居民没有发生这一现象。 说明人家重视预防!, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Tue Feb 17 23:10:00 CST 2015, time=2015-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16320, encodeId=3f761632023, content=到底要不要减少胆固醇摄入?, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=49.4.167.**, createdTime=Tue Feb 17 22:55:00 CST 2015, time=2015-02-17, status=1, ipAttribution=)]
    2015-02-17 medcardio

    而著名的弗莱明翰心脏研究发现,随时间的推移,基线总胆固醇水平低者呈上升变化,而基线总胆固醇水平高者呈降低变化,该现象被称为“向均值回归”。看来,我国居民没有发生这一现象。 说明人家重视预防!

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=16880, encodeId=3f3a168803d, content=不错的文章,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=167, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f2fb1607679, createdName=orthoW, createdTime=Tue Feb 24 11:19:00 CST 2015, time=2015-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1250412, encodeId=567e12504120f, content=<a href='/topic/show?id=7d6f52988e1' target=_blank style='color:#2F92EE;'>#患病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52988, encryptionId=7d6f52988e1, topicName=患病率)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Thu Feb 19 13:15:00 CST 2015, time=2015-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16380, encodeId=1fa7163808b, content=请注明引用出处,好吗。, beContent=null, objectType=article, channel=null, level=null, likeNumber=148, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=101.26.186.**, createdTime=Wed Feb 18 17:43:00 CST 2015, time=2015-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16346, encodeId=3234163461a, content=预防…饮食…锻炼, beContent=null, objectType=article, channel=null, level=null, likeNumber=180, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200609/ef6a57dbe7f1489dad7446b7c5217858/d5e4fe65996c4446a029b0f5d056abb1.jpg, createdBy=6b011518214, createdName=午夜星河, createdTime=Wed Feb 18 06:59:00 CST 2015, time=2015-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16335, encodeId=9ca4163354d, content=而著名的弗莱明翰心脏研究发现,随时间的推移,基线总胆固醇水平低者呈上升变化,而基线总胆固醇水平高者呈降低变化,该现象被称为“向均值回归”。看来,我国居民没有发生这一现象。 说明人家重视预防!, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Tue Feb 17 23:10:00 CST 2015, time=2015-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16320, encodeId=3f761632023, content=到底要不要减少胆固醇摄入?, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=49.4.167.**, createdTime=Tue Feb 17 22:55:00 CST 2015, time=2015-02-17, status=1, ipAttribution=)]
    2015-02-17 49.4.167.**

    到底要不要减少胆固醇摄入?

    0

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