CLIN CANCER RES：头颈部肿瘤患者血浆外泌体抑制淋巴细胞功能

2017-08-29 MedSci MedSci原创

头颈部肿瘤通常会诱导产生强力的免疫抑制，有助于疾病进展并影响免疫治疗的疗效。头颈部肿瘤患者的血液中外泌体含量升高，会对抗肿瘤反应产生负向影响。CLIN CANCER RES近期发表了一篇文章，研究头颈部肿瘤患者血浆中外泌体含量，并评估其对免疫功能紊乱及疾病活性的影响。

头颈部肿瘤通常会诱导产生强力的免疫抑制，有助于疾病进展并影响免疫治疗的疗效。头颈部肿瘤患者的血液中外泌体含量升高，会对抗肿瘤反应产生负向影响。CLIN CANCER RES近期发表了一篇文章，研究头颈部肿瘤患者血浆中外泌体含量，并评估其对免疫功能紊乱及疾病活性的影响。作者共收集了38例头颈部肿瘤患者和14例健康患者的血浆外泌体。检测了外泌体的形态，大小，数量，蛋白以及所含分子。通过共培养的手段研究外泌体介导的对正常人淋巴细胞亚群以及NK细胞的影响，并将该结果与疾病分期和活性相联系。研究结果表明，疾病活动程度高的患者的外泌体在诱导CD8+T细胞凋亡，抑制CD4+T细胞增殖，以及上调Treg细胞功能方面更有效力。疾病活动程度高的患者的外泌体还会下调NK细胞NKG2D表达水平。文章最后认为，头颈部肿瘤患者血浆外泌体含有免疫抑制分子并且会干扰免疫细胞功能。外泌体介导的免疫抑制与头颈部肿瘤患者疾病活动程度有关，表明血浆外泌体是头颈部肿瘤进展的潜在分子标志。原始出处：Sonja Ludwig,Theofanis Floros,et al.Suppression of Lymphocyte Func

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2017-12-22 仁心济世

#血浆外泌体#

89 0
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2017-08-31 三生有幸9135

学习一下谢谢分享

123 0
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2017-08-31 wetgdt

#淋巴细胞#

0 0
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2017-08-31 lanyan20020087

#肿瘤患者#

104 0
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2017-08-31 wshxjq

#头颈部#

130 0
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2017-08-31 般若傻瓜

#细胞功能#

91 0
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2017-08-31 木头人519

#颈部#

78 0
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2017-08-29 luominglian113

学习了.谢谢分享

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