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PLoS One:B族维生素可降低肾细胞癌风险

2015-10-30 Seven L 译 MedSci原创

先前有研究表明一碳代谢相关的营养素与癌症相关,研究者进行了一项荟萃分析,探究一碳代谢相关因素与肾细胞癌 (RCC) 风险。研究者于2015-3月检索了PubMed, EMBASE, and Cochrane等数据库,纳入了关于一碳与代谢相关因素与RCC量化风险间的相关研究。通过随机效应模型计算两者间RRs和CIs。通过检索共有463篇文献和摘要,其中有7项队列来自5个观察性研究,涉及133,995

先前有研究表明一碳代谢相关的营养素与癌症相关,研究者进行了一项荟萃分析,探究一碳代谢相关因素与肾细胞癌 (RCC) 风险。

研究者于2015-3月检索了PubMed、EMBASE、Cochrane等数据库,纳入了关于一碳与代谢相关因素与RCC量化风险间的相关研究。通过随机效应模型计算两者间RRs和CIs。

通过检索共有463篇文献和摘要,其中有7项队列来自5个观察性研究,涉及133,995名人,其中有 2,441 名RCC患者。

将维他命B12含量最高的组与最低的相比,合并后的RCC发生风险RRs=0.72 (95%CI: 0.52-1.00; P = 0.048) 。此外,叶酸补充每天增加 100 μg可以降低3%的RCC风险 (RR, 0.97; 95%CI: 0.93-1.00; P = 0.048)。同样,维生素B2增加5 nmol/L,也可以降低RCC风险RRs= 0.94 (95%CI: 0.89-1.00; P = 0.045)。敏感性分析显示血清中高浓度维生素B6,可以减少RCC风险(RR, 0.83; 95%CI: 0.77-0.89; P < 0.001)。

该荟萃分析结果表明,对于该研究人群,血清中维生素B2、B6、B12浓度越高,叶酸补充越多,可以降低肾细胞癌 (RCC) 风险。

原始出处:

Mao B, Li Y, Zhang Z,et al.One-Carbon Metabolic Factors and Risk of Renal Cell Cancer: A Meta-Analysis.PLoS One. 2015 Oct 29;10(10):e0141762.


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    2016-03-21 sjq027
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