Neural Regen Res ：三七总皂苷减轻缺氧复氧所致神经元的氧化应激损伤

《中国神经再生研究（英文版）》杂志于2012年12月36期出版的一项关于“Panax notoginseng saponin attenuates hypoxia/ reoxygenation-induced oxidative stress in cortical neurons”的研究发现：三七总皂甙可①显着增强缺氧复氧损伤神经元的活力。②降低缺氧复氧损伤神经元丙二醛和一氧化氮的含量。③提高缺氧复氧损伤神经元超氧化物歧化酶活性。④下调缺氧复氧损伤神经元诱导型和神经元型一氧化氮合酶的表达。⑤剂量依赖性减轻缺氧复氧引起的神经元氧化应激损伤。作者认为，三七总皂甙对缺氧复氧损伤的大鼠大脑皮质神经元具有保护作用。

doi:10.3969/j.issn.1673-5374.2012.36.001
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Panax notoginseng saponin attenuates hypoxia/ reoxygenation-induced oxidative stress in cortical neurons

Chen Yan, Jinqiang Zhu, Xiaoxu Jia, Chao Wang, Shaoxia Wang, Liyuan Kang

The present study monitored the effect of 2, 10, and 50 mg/L of Panax notoginseng saponin exposure following hypoxia-reoxygenation injury in fetal rat cortical neurons. Results showed that varying doses of Panax notoginseng saponin significantly enhanced the cell viability of neurons, reduced malondialdehyde content, increased superoxide dismutase activity, inhibited mRNA and protein expression of inducible and neuronal nitric oxide synthase, and decreased the release of nitric oxide in hypoxia/reoxygenation injured cells. In particular, 50 mg/L of Panax notoginseng saponin was the most effective dose. These findings suggest that Panax notoginseng saponin can attenuate neuronal oxidative stress injury caused by hypoxia/reoxygenation in a dose-dependent manner.