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IBD: 焦虑和抑郁症状与小儿克罗恩病患者未来疾病活动无关

2021-07-14 MedSci原创 MedSci原创

对患有克罗恩病 (CD) 的成年人的研究表明,在疾病活动恶化之前,CD患者的心理健康状况大部分会出现恶化。但是这样的现象是不是也会在儿童CD患者中出现。

      对患有克罗恩病 (CD) 的成年人的研究表明,在疾病活动恶化之前,CD患者的心理健康状况大部分会出现恶化。但是这样的现象是不是也会在儿童CD患者中出现,目前还没有研究进行报道,因此,本项研究旨在评估抑郁症和/或焦虑症是否预示着儿童 CD 疾病活动的恶化。

 

      通过炎症性肠病的全球合作网络,9 至 17 岁患有 CD 的儿童完成了患者报告结果测量信息系统 (PROMIS) 的填写和克罗恩病活动指数 (sCDAI)的评估。然后使用一般线性模型,研究人员检查了基线 PROMIS 小儿焦虑和抑郁症状评分如何与随后的 sCDAI 评分(平均调查间隔 6.4 个月)存在相关性。模型包括基线 PROMIS 小儿焦虑和抑郁症状评分、基线 sCDAI、性别、年龄、父母教育、种族/民族和先前的 IBD 相关手术。

 

      研究总共纳入159 名 CD 儿童(平均年龄 14 岁,45% 女性,84% 处于基线缓解期)。我们发现基线 PROMIS 小儿焦虑评分与随后的 sCDAI 之间没有关联(OR:-0.89;95% CI -4.81 至 3.03)。基线 PROMIS 小儿抑郁症状评分与未来的 sCDAI 无关(OR: <0.01;95% CI -4.54 至 4.53)。在基线缓解患者的亚组分析中,仍然不存在相关性。

 

      本项研究证实焦虑和抑郁症状都与儿童 CD 的后续疾病活动无关。这些发现与成人 IBD 研究形成强烈对比。

 

 

原始出处:

Erica J Brenner. Et al. Anxiety and Depressive Symptoms Are Not Associated With Future Pediatric Crohn’s Disease Activity. Inflammatory Bowel Diseases.2021.

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    2021-07-16 bnurmamat
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    2021-07-14 ms4000000260930224

    学习了

    0

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    2021-07-14 王旭锋

    劳劳碌碌热热后

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1756115, encodeId=e9021e56115f4, content=<a href='/topic/show?id=78e1e06924a' target=_blank style='color:#2F92EE;'>#疾病活动#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70692, encryptionId=78e1e06924a, topicName=疾病活动)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=57fa37069463, createdName=xue8614, createdTime=Thu Nov 25 10:00:08 CST 2021, time=2021-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2035701, encodeId=8f372035e017d, content=<a href='/topic/show?id=8873468e8a8' target=_blank style='color:#2F92EE;'>#小儿克罗恩病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46878, encryptionId=8873468e8a8, topicName=小儿克罗恩病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c737344, createdName=lg.zhao, createdTime=Sat Jan 01 02:00:08 CST 2022, time=2022-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1263664, encodeId=edad126366452, content=<a href='/topic/show?id=75bc930217' target=_blank style='color:#2F92EE;'>#IBD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9302, encryptionId=75bc930217, topicName=IBD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc0372, createdName=bnurmamat, createdTime=Fri Jul 16 07:00:08 CST 2021, time=2021-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1434910, encodeId=ce211434910b8, content=<a href='/topic/show?id=952a54980e5' target=_blank style='color:#2F92EE;'>#抑郁症状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54980, encryptionId=952a54980e5, topicName=抑郁症状)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Fri Jul 16 07:00:08 CST 2021, time=2021-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=999597, encodeId=4fd899959e32, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=579c5526325, createdName=ms4000000260930224, createdTime=Wed Jul 14 23:24:51 CST 2021, time=2021-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=999571, encodeId=54419995e1da, content=劳劳碌碌热热后, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ce3d5549193, createdName=王旭锋, createdTime=Wed Jul 14 22:37:16 CST 2021, time=2021-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050569, encodeId=46c6105056957, content=焦虑是当年年轻人的共同问题,需要认真对待。, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Wed Jul 14 19:00:08 CST 2021, time=2021-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=999469, encodeId=2e15999469a1, content=很认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210714/5f9e2d9c061d47adaf559efa12e56a10/f9aeedc6ddf94c1a8f7991ae9cb55216.jpg, createdBy=7f195414940, createdName=Flora0708, createdTime=Wed Jul 14 17:14:18 CST 2021, time=2021-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=999459, encodeId=704f99945931, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Wed Jul 14 16:52:00 CST 2021, time=2021-07-14, status=1, ipAttribution=)]
    2021-07-14 明天jing

    焦虑是当年年轻人的共同问题,需要认真对待。

    0

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    2021-07-14 Flora0708

    很认真学习了

    0

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    2021-07-14 医鸣惊人

    认真学习了

    0

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