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Allergy Asthma Immunol Res:学龄前儿童过敏性鼻炎及呼出气一氧化氮的临床应用

2017-05-14 AlexYang MedSci原创

学龄前儿童过敏性鼻炎(AR)的本质仍旧没有完全的鉴定。最近,有研究调查了AR的流行程度和在学龄前儿童的相关风险因子,并且还评估了呼出气一氧化氮(FeNO)的临床应用。研究方法为基于普通群体的横断式调查法,包括了来自韩国的933名学龄前儿童(3-7岁)。研究中的AR定义为在过去12个月有鼻部症状和医师诊断的AR。研究发现,目前AR在学龄前儿童的流行度为17%(156/919)。在婴儿期霉菌的接触(a

学龄前儿童过敏性鼻炎(AR)的本质仍旧没有完全的鉴定。最近,有研究调查了AR的流行程度和在学龄前儿童的相关风险因子,并且还评估了呼出气一氧化氮(FeNO)的临床应用。研究方法为基于普通群体的横断式调查法,包括了来自韩国的933名学龄前儿童(3-7岁)。研究中的AR定义为在过去12个月有鼻部症状和医师诊断的AR。

研究发现,目前AR在学龄前儿童的流行度为17%(156/919)。在婴儿期霉菌的接触(adjusted odds ratio [aOR], 1.67; 95% confidence interval [CI], 1.15-2.43)和抗生素的使用(aOR, 1.97; 95% CI, 1.33-2.90)与目前增加患AR风险相关,然而如果有年龄更大的兄弟姐妹(aOR, 0.52; 95% CI, 0.35-0.75)时能够减少风险。与非遗传性过敏鼻炎(12.43; range of 1standard deviation [SD], 7.31-21.14 vs 8.25; range of 1SD, 5.62-12.10, P=0.001)或者非遗传性过敏健康儿童(8.58; range of 1SD, 5.51-13.38, P<0.001)相比,患有目前遗传性过敏AR的儿童具有显著性的更高的FeNO几何平均水平。另外,FeNO水平在目前遗传性AR中比遗传性过敏健康儿童中更高(9.78; range of 1SD, 5.97-16.02, P=0.083)。

最后,研究人员指出,在婴儿期,霉菌的接触和抗生素使用增加了患目前AR的风险,然而有一个年龄更大的兄弟姐妹就可以减少风险。与非遗传过敏性鼻炎病例相比,患有目前遗传过敏性AR的儿童展现了更高的FeNO水平,表明了FeNO水平也许是一个有用的区分标记来区分学龄前儿童AR的亚型。

原始出处:

Yoon J, Choi YJ, Lee E et al. Allergic Rhinitis in Preschool Children and the Clinical Utility of FeNO. Allergy Asthma Immunol Res. Jul 2017.

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    2017-05-15 智慧医人
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  4. 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    2017-05-17 zutt
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  7. 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  8. 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createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Tue May 16 03:50:00 CST 2017, time=2017-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1337369, encodeId=3cec133e3693e, content=<a href='/topic/show?id=96fd19358fa' target=_blank style='color:#2F92EE;'>#一氧化氮#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19358, encryptionId=96fd19358fa, topicName=一氧化氮)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKjqGDO7icVKUiaT7urgwXvnvzWtp0fMFU46Xfib8oavFKygiaWtibXReS6ZUh3PImsNicGAwTO5HXxoicnA/132, createdBy=ee262500130, createdName=ms7474195563676018, createdTime=Tue May 16 03:50:00 CST 2017, time=2017-05-16, status=1, ipAttribution=)]
    2017-05-17 laoli

    谢谢分享,学习了!

    0

  9. 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    2017-05-16 膀胱癌
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