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Schizophr Res:一种新的精神分裂症持续性阴性症状评估标准

2018-07-17 中国科学院心理健康重点实验室 陈楚侨研究组 中科院心理所

精神分裂症是一种复杂的神经发育障碍,其特征主要表现为阳性症状和阴性症状。尽管精神分裂症的临床诊断主要基于幻觉和妄想等阳性症状,但最终决定精神分裂症患者功能结局的是阴性症状,例如快感缺乏和动机缺乏。存在快感缺乏和动机缺乏的患者在日常生活中体验愉快事件的能力会降低,并且丧失有意义的目标导向行为的动机。首发的精神分裂症患者中约有20%至30%最终会进入治疗抵抗阶段,其特征是持续存在的阴性症状,称为持续性

精神分裂症是一种复杂的神经发育障碍,其特征主要表现为阳性症状和阴性症状。尽管精神分裂症的临床诊断主要基于幻觉和妄想等阳性症状,但最终决定精神分裂症患者功能结局的是阴性症状,例如快感缺乏和动机缺乏。存在快感缺乏和动机缺乏的患者在日常生活中体验愉快事件的能力会降低,并且丧失有意义的目标导向行为的动机。首发的精神分裂症患者中约有20%至30%最终会进入治疗抵抗阶段,其特征是持续存在的阴性症状,称为持续性阴性症状(PNS)。因此,PNS是精神分裂症研究的主题之一。

另一方面,近来研究对阴性症状的定义发生了新的变化,提出了最新的两因子模型(动机与愉快感因子和表达因子)。因此,采用现有的临床评定量表来定义及区分PNS时是存在概念和方法上的限制的。阴性症状临床评估访谈量表(CAINS)便是基于两因子模型发展出的一种阴性症状评估工具。然而,目前尚无任何研究使用CAINS来甄别PNS。

为了弥补这方面研究的空白,中国科学院心理健康重点实验室神经心理学和应用认知神经科学(NACN)实验室的陈楚侨研究组与国际合作者一起确定了如何用CAINS甄别PNS的方法。

研究者对206名精神分裂症患者进行了CAINS评估,并使用常规评定量表将其分为PNS组(n = 57)和非PNS组(n=149),然后使用受试者工作特征曲线 (receiver operating characteristic curve,简称ROC曲线)分析来确定CAINS在区分PNS时的诊断效度及界值。

研究结果表明, CAINS总分,动机和愉快感分量表(MAP)和表达分量表(EXP)甄别PNS的界值分别为25,17和5。根据研究结果推荐使用CAINS总分和MAP子量表的界值来区分PNS与非PNS。CAINS的阳性预测值(PPV)和阴性预测值(NPV)分别为81.54%和97.16%。这些研究结果表明,CAINS可以很好地对精神分裂症PNS进行区分,这对于PNS未来的临床试验研究,尤其是在界定PNS方面具有很大的作用。

该研究受国家自然科学基金、国家重点研究发展计划、北京市科学技术委员会和北京市科技领军人才培养项目的资助。

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channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3b24606172648eea459125cb74754afe.jpg, createdBy=6c022216608, createdName=liumin1987, createdTime=Wed Jul 18 08:10:10 CST 2018, time=2018-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332385, encodeId=e74133238529, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Wed Jul 18 07:25:51 CST 2018, time=2018-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332370, encodeId=3c3a3323e097, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Wed Jul 18 06:33:17 CST 2018, time=2018-07-18, status=1, ipAttribution=)]
    2018-07-19 jihuaijun1112

    学习学习学习

    0

  5. 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objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Wed Jul 18 06:33:17 CST 2018, time=2018-07-18, status=1, ipAttribution=)]
    2018-07-18 随梦飞扬

    首发的精神分裂症患者中约有至最终会进入治疗抵抗阶段其特征是持续存在的阴性症状称为持续性阴性症状

    0

  6. 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objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Wed Jul 18 06:33:17 CST 2018, time=2018-07-18, status=1, ipAttribution=)]
    2018-07-18 随梦飞扬

    精神分裂症是一种复杂的神经发育障碍其特征主要表现为阳性症状和阴性症状

    0

  7. 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channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3b24606172648eea459125cb74754afe.jpg, createdBy=6c022216608, createdName=liumin1987, createdTime=Wed Jul 18 08:10:10 CST 2018, time=2018-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332385, encodeId=e74133238529, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Wed Jul 18 07:25:51 CST 2018, time=2018-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332370, encodeId=3c3a3323e097, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Wed Jul 18 06:33:17 CST 2018, time=2018-07-18, status=1, ipAttribution=)]
    2018-07-18 zb1235672

    学习了

    0

  8. 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channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3b24606172648eea459125cb74754afe.jpg, createdBy=6c022216608, createdName=liumin1987, createdTime=Wed Jul 18 08:10:10 CST 2018, time=2018-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332385, encodeId=e74133238529, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Wed Jul 18 07:25:51 CST 2018, time=2018-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332370, encodeId=3c3a3323e097, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Wed Jul 18 06:33:17 CST 2018, time=2018-07-18, status=1, ipAttribution=)]
    2018-07-18 liumin1987

    好学习了

    0

  9. 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objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Wed Jul 18 06:33:17 CST 2018, time=2018-07-18, status=1, ipAttribution=)]
    2018-07-18 sunfeifeiyang

    0

  10. 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Transl Psychiatry:全血转录组分析揭示了精神分裂症中微生物多样性的增加

人类微生物组在健康和疾病中的作用日益受到重视。本研究中,研究人员探究了192名参与者血液中微生物群落的组成,包括健康对照者和三种疾病患者:精神分裂症、肌萎缩侧索硬化症和双相性精神障碍。使用高质量的未映射的RNA测序读数作为候选微生物读数,对全血中检测到的微生物转录物进行了分析。结果检测到血液中的多种细菌和古菌门。有趣的是,与其他三组相比,精神分裂症患者的微生物多样性增加。且在另一组精神分裂症病例对

SCI REP:女性首次生育年龄与精神分裂症风险增加有关

该研究结果表明在英国生物样本库中,女性首次生育年龄较早和较晚与精神分裂症的遗传风险增加有关。这些发现为有助于为了解复杂的生物社会风险架构因素提供新的见解,这些因素支持了父母年龄与后代心理健康之间的关联。

Schizophrenia Bull:精神分裂症高危群体情绪识别任务中的杏仁核功能连接异常

尽管已有研究发现精神分裂症患者存在面孔情绪加工缺损,例如行为研究发现患者识别面孔表情能力受损,脑成像研究也发现杏仁核、内侧前额叶等区域在进行面孔表情加工时存在异常的活动,但是对于该任务下相关脑区的功能连接是否存在异常尚不清楚。

Neuropsychologia:嗅觉功能减退可能是精神分裂症谱系障碍的早期识别标志

已有充足证据表明,精神分裂症患者存在气味识别能力的减退。然而,气味识别能力减退能否作为精神分裂症的早期识别指标,仍是一个有待解决的问题。

FDA警告:Keytruda和Tecentriq疗效并不优于化疗:杨森精神分裂症药物获批上市..

FDA对全美范围内的医生、试验调查人员和公众发出用药警告,称默克Keytruda和罗氏Tecentriq在最近的试验中出现危险信号。来自监督委员会的早期审查中的两项分别对两种药物的单独研究发现,接受低水平PD-L1抑制剂免疫疗法患者的生存几率低于选择正常铂化疗的患者。

JAMA Psychiatry:脑部褶皱告诉你患精神分裂症的风险!

精神分裂症患者在发病前通常产生焦虑、抑郁或睡眠问题等症状。但是,这些症状与许多其他精神健康状况重叠,并不意味着一定会发展成精神分裂症,因此,很难根据它们判断是否患病。现在,一项新的研究表明,精神分裂症患者大脑中可能有一个特殊的“指纹”,通过分析这些大脑褶皱中的“指纹”可以帮助预测哪些有高风险精神分裂症的年轻人会继续患上这种疾病。

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