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CLIN CHEM:在社区人群中AGE-CML,sRAGE和esRAGE与糖尿病和心脏代谢危险因素的横断面分析

2018-03-27 MedSci MedSci原创

晚期糖基化终产物(AGEs)及其受体被认为是糖尿病并发症发展的中心,但在以往研究中AGEs与糖尿病和心脏代谢结局的相关性尚不清楚。 研究人员使用ELISA试验检测来自社区动脉粥样硬化风险研究的1874名参与者的N(6) - 羧甲基赖氨酸(AGE-CML),AGEs(sRAGE)的可溶性受体和AGEs的内源性分泌受体(esRAGE)。经过横断面分析,以评估这些生物标记与人口统计学,糖尿病,高血

晚期糖基化终产物(AGEs)及其受体被认为是糖尿病并发症发展的中心,但在以往研究中AGEs与糖尿病和心脏代谢结局的相关性尚不清楚。 研究人员使用ELISA试验检测来自社区动脉粥样硬化风险研究的1874名参与者的N(6) - 羧甲基赖氨酸(AGE-CML),AGEs(sRAGE)的可溶性受体和AGEs的内源性分泌受体(esRAGE)。经过横断面分析,以评估这些生物标记与人口统计学,糖尿病,高血糖症,心脏代谢指标和编码RAGE,AGER(晚期糖基化终产物特异性受体)基因的遗传变异体的关联。 对人口统计学和体重指数(BMI)调整后,糖尿病或血红蛋白A 1c的 AGE-CML,sRAGE或esRAGE无显着差异。黑人种族和老人遗传变异与sRAGE和esRAGE相关性较低,即使在调整后[黑人与白人之间在sRAGE中的百分比差异(95%CI):-29.17(-34.86至-23.48),esRAGE:-26.97(-33.11至-20.84); 在sRAGE中的rs2070600:-30.13(-40.98至-19.29),和esRAGE:-30.32(-42.42至-18.21); sRAGE中

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    2018-03-28 wangbingxhy
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    2018-03-27 明月清辉

    谢谢分享.学习了

    0

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