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Lancet respir med:中国小气道功能障碍患病率及风险因素研究

2020-06-28 网络 网络

小气道功能障碍非常普遍,吸烟是一个主要的可改变的危险因素,同时PM2.5暴露和BMI增加也是重要的风险因素

小气道功能障碍是一种常见,但易被忽视的呼吸异常。近日研究人员通过支气管扩张前后肺活量法评估中国小气道功能障碍的患病率。
 
2012年6月至2015年5月,研究人员采用多阶段分层抽样法,从10个省抽取50479名参与者。研究人员根据以下三项肺功能指标中至少有两项低于预测值的65%来诊断小气道功能障碍:最大呼气中期流量、用力呼气流量(FEF)50%和FEF 75%。小气道功能障碍进一步分为前小气道功能障碍(定义为支气管扩张剂吸入前具有正常的FEV1和FEV1增强肺活量[FVC]比值)和后小气道功能障碍(定义为支气管扩张剂吸入前、后具有正常的FEV1和FEV1/FVC比值)。分析吸烟、其他生活方式和环境因素对小气道功能障碍的影响。最后将本研究结果应用于全国人口普查数据,进一步估计了中国小气道功能障碍的病例总数。
 
总的来说,小气道功能障碍的患病率为43.5%,前小气道功能障碍为25.5%,后小气道功能障碍为11.3%。经多因素回归分析,小气道功能障碍的风险与年龄、性别、城市化、教育程度、吸烟、被动吸烟、生物量、PM2.5、儿童慢性咳嗽史、儿童肺炎或支气管炎史,父母呼吸系统疾病史,体重指数(BMI)增加5 kg/m2显著相关。男性吸烟与小气道后功能障碍之间也存在剂量-反应关系,而女性则不存在。研究人员估计,在2015年,中国有4.26亿成人有小气道功能障碍,2.53亿有前小气道功能障碍,1.11亿人有后小气道功能障碍。
 
在中国,小气道功能障碍非常普遍,吸烟是一个主要的可改变的危险因素,同时PM2.5暴露和BMI增加也是重要的风险因素。
 
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    2020-07-22 nxwyy

    👍

    0

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    2020-06-28 howi
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    2020-06-28 goodbing

    顶刊就是不一样,质量很高,内容精彩!学到很多

    0

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