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Obstet Gynecol:宫内节育器使用与卵巢癌风险

2019-09-15 xing.T MedSci原创

由此可见,根据对现有回顾性数据的评价,宫内节育器使用与卵巢癌发病率降低有关。不幸的是,有关宫内节育器在卵巢癌预防中作用的前瞻性研究是有限的。

近日,妇产科权威杂志Obstetrics and Gynecology上发表了一研究文章,研究人员旨在通过系统回顾文献和Meta分析,探讨宫内节育器(IUD)使用与卵巢癌风险之间的关系。

研究人员检索了MEDLINE、EMBASE、Cochrane图书馆、Web of Science核心馆藏,检索时间从数据库成立至2018年6月。对于MEDLINE检索,研究人员采用的MeSH术语包括“宫内节育器”和“卵巢肿瘤”,但也检索了“内部*”、“卵巢*”和“输卵管”,以及“癌症”和“癌”,这些术语作为关键词包括了所有可能的变体。其他数据库中使用了类似的检索词。研究人员还检索了ClinicalTrials.gov。研究人员对收集了宫内节育器使用和卵巢癌诊断的个体水平数据的病例对照和队列研究进行了严格审查和数据提取。通过系统数据库审查查阅了399篇文献的摘要,研究人员通过谷歌学术确定另外发表的200篇文献,共发现15项关于宫内节育器使用与卵巢癌事件的个人水平数据的研究。在严格审查中,其中11项研究用于荟萃分析。所有案例报告和评论都被排除在外。

数据经统一格式、加权和计算总的比值比(OR)。研究人员确定协变量分别进行评估,并进行随机效应荟萃分析以确认最小偏差。数据的协调和加权显示,使用IUD和发生卵巢癌之间关联的OR为0.68(95%CI为0.62-0.75)。协变量之间没有显著差异。所有研究中的异质性均为I2=68%。

由此可见,根据对现有回顾性数据的评价,宫内节育器使用与卵巢癌发病率降低有关。不幸的是,有关宫内节育器在卵巢癌预防中作用的前瞻性研究是有限的。 

原始出处:

Wheeler, Lindsay J,et al.Intrauterine Device Use and Ovarian Cancer Risk A Systematic Review and Meta-analysis.Obstetrics & Gynecology.2019.https://journals.lww.com/greenjournal/Abstract/publishahead/Intrauterine_Device_Use_and_Ovarian_Cancer_Risk__A.97598.aspx

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    2020-08-03 yhy100200
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    2020-07-03 sjq027
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相关资讯

2017 ACOG实践简报:长效可逆性避孕-埋植剂和宫内节育器(No.186)

2017年11月,美国妇产科医师学会(ACOG)发布了关于长效可逆性避孕-埋植剂和宫内节育器的相关指南。埋植剂和宫内节育器也被称作长效可逆避孕措施,是最有效的避孕方法,本文的主要目的是针对埋植剂和宫内节育器的恰当使用和管理提供知道建议。

注意:宫内节育器会增加癌症风险?

赫尔辛基大学一项研究报告中指出,激素避孕和染发剂是乳腺癌的风险因素。此次分析结果来自于 8000 例乳腺癌病例,以及 20000 份得到控制的病例。

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Eisenberg DL等人纳入了16-45岁具有正常月经周期和要求避孕的未生育过的和生育过的女性,对其进行了一项非盲、部分随机试验,通过3年数据评估新的设计为可以使用7年以上的52mg左炔诺孕酮宫内节育器(LNG20)的有效性和安全性。初始结局指标为16-35岁女性按珀尔指数计算的妊娠率和有效性。其中36-45岁女性纳入该研究仅仅是针对LNG20的安全性的研究。研究期间研究人员对所有参与者大约每

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对于初产妇,虽然自我使用阴道利多卡因凝胶不减请宫内节育器放置引起的疼痛,但可以减轻拉钩带来的疼痛。

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研究发现,采用注射醋酸甲羟孕酮、宫内节育器或乙羟基二降孕甾烯炔酮避孕人群的HIV感染风险无显著差异

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