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Circulation：NLRP3炎症小体可促进房颤的发生发展

2018-11-17 MedSci MedSci原创

NLRP3炎症小体房颤心肌细胞
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心房颤动(AF)常与炎症反应增强相关。NLRP3(NACHT、 LRR和保护PYD结构域的蛋白质3)炎症体介导免疫细胞的caspase-1激活和白介素-1β释放，但尚不明确其在心肌细胞(CMs)中的具体作用。现研究人员对CM NLRP3炎症小体在AF中的作用进行研究。通过免疫印迹法检测阵发性AF或长期持续性（慢性）AF患者的心房全组织溶解物和CMs的NLRP3炎症小体的激活。为明确NLRP3的CM

心房颤动(AF)常与炎症反应增强相关。NLRP3(NACHT、 LRR和保护PYD结构域的蛋白质3)炎症体介导免疫细胞的caspase-1激活和白介素-1β释放，但尚不明确其在心肌细胞(CMs)中的具体作用。现研究人员对CM NLRP3炎症小体在AF中的作用进行研究。

通过免疫印迹法检测阵发性AF或长期持续性（慢性）AF患者的心房全组织溶解物和CMs的NLRP3炎症小体的激活。为明确NLRP3的CM特异性激活是否可有效促进AF，研究人员建立CM特异性表达持续性活化的NLRP3的小鼠模型（CM-KI）。

在阵发性房颤和慢性房颤患者心房中，NLRP3炎性小体活性增强。CM-KI小鼠出现自发性早发型房颤和诱导性房颤，并可被NLRP3炎性小体特异性抑制剂MCC950减弱。此外，CM-KI小鼠还出现异位电活动、肌浆网Ca2+释放异常、心房有效不应期缩短、心房肥大。腺相关病毒亚型-9介导的CM特异性敲除Nlrp3可抑制CM-KI小鼠的AF发展。最后，抑制Nlrp3可阻止CREM转基因小鼠（一种公认的自发性AF的小鼠模型）AF的发生。

本研究揭示了CM NLRP3炎症小体信号的新的病理生理作用，并与AF病理相联系，同时表明抑制NLRP3或可作为治疗AF的新方法。


原始出处：

Chunxia Yao，et al.Enhanced Cardiomyocyte NLRP3 Inflammasome Signaling Promotes Atrial Fibrillation. 24 Jul 2018. Circulation. 2018；138：2227–2242

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    2019-03-11 wgsun

    #发生发展#

    0

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    2018-11-28 bluefate131

    #NLRP3炎症小体#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2030742, encodeId=ac012030e4266, content=<a href='/topic/show?id=71353e8964f' target=_blank style='color:#2F92EE;'>#发生发展#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37896, encryptionId=71353e8964f, topicName=发生发展)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=346311, createdName=wgsun, createdTime=Mon Mar 11 02:54:00 CST 2019, time=2019-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1690690, encodeId=29ff169069076, content=<a href='/topic/show?id=f684128e260' target=_blank style='color:#2F92EE;'>#NLRP3炎症小体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12872, encryptionId=f684128e260, topicName=NLRP3炎症小体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=720529078091, createdName=bluefate131, createdTime=Wed Nov 28 03:54:00 CST 2018, time=2018-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1407751, encodeId=1f11140e75172, content=<a href='/topic/show?id=a22412862b3' target=_blank style='color:#2F92EE;'>#NLR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12862, encryptionId=a22412862b3, topicName=NLR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8cd32710930, createdName=yuandd, createdTime=Mon Nov 19 11:54:00 CST 2018, time=2018-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1538784, encodeId=2f581538e84bc, content=<a href='/topic/show?id=93341286ee6' target=_blank style='color:#2F92EE;'>#NLRP3#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12867, encryptionId=93341286ee6, topicName=NLRP3)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=981f13051678, createdName=vera_1207, createdTime=Mon Nov 19 11:54:00 CST 2018, time=2018-11-19, status=1, ipAttribution=)]
    2018-11-19 yuandd

    #NLR#

    0

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    2018-11-19 vera_1207

    #NLRP3#

    0

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