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Prostate Cancer P D:接受重症监护治疗的转移性前列腺癌患者接受姑息治疗的当前趋势和社会障碍研究

2019-11-19 AlexYang MedSci原创

在晚期癌症患者中使用住院病人姑息治疗(IPC)是较为完善的指南建议。之前的分析阐释了泌尿生殖系(GU)癌症患者在4个检查的原发性癌症(肺癌、乳腺癌、结直肠癌和GU)患者中受益于IPC的比例为排序第3。基于这些结果,研究人员在接受重症监护治疗(CCT)的转移前列腺癌(mPCa)患者中调查了IPC使用的当前趋势和预测因子。研究发现,在接受CCT治疗的4168名mPCa患者中,449名(11.3%)进行

在晚期癌症患者中使用住院病人姑息治疗(IPC)是较为完善的指南建议。之前的分析阐释了泌尿生殖系(GU)癌症患者在4个检查的原发性癌症(肺癌乳腺癌直肠癌和GU)患者中受益于IPC的比例为排序第3。基于这些结果,研究人员在接受重症监护治疗(CCT)的转移前列腺癌(mPCa)患者中调查了IPC使用的当前趋势和预测因子。

研究发现,在接受CCT治疗的4168名mPCa患者中,449名(11.3%)进行了IPC,且使用率从1.2%增加到了22.3%(EAPC: +19.6%, p<0.001)。当根据地区、种族和受教育状态进行分层分析时,IPC使用增长最高的在南方(从0到25.4%, EAPC: +27.6%)、白种人(从1.5到24.4 %, EAPC: +19.8%; p<0.001)和教学医院(从0.9到26.2 %, EAPC: +19.6%; p<0.001)。在多变量回归模型中(MLR),教学状态(风险比(OR):1.74,p<0.001)和当代年份间隔(OR: 4.63, p<0.001)与更高的IPC使用比例相关。相反,非裔美国种族(OR: 0.66, p<0.001)和GU疾病的初次诊断(OR: 0.49, p<0.001)和入院时的肠道(GI)疾病(OR: 0.61, p=0.02)与更低的IC使用率相关。

最后,研究人员指出,IPC使用率在接受CCT治疗的mPCa患者中在2004年到2015年急剧增加。IPC使用增加最多的在南方、白人种族和教学医院。非裔美国种族和非教学状态为更低IPC使用的独立预测因子,并且是改善接受CCT的mPCa患者进行IPC治疗的出发点。

原始出处:

Elio Mazzone, Francesco A. Mistretta, Sophie Knipper et al. Temporal trends and social barriers for inpatient palliative care delivery in metastatic prostate cancer patients receiving critical care therapies. Prostate Cancer P D. 04 Nov 2019

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    2019-11-21 lsndxfj
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1791593, encodeId=5a911e9159320, content=<a href='/topic/show?id=b77f14e4541' target=_blank style='color:#2F92EE;'>#Prostate Ca#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14745, encryptionId=b77f14e4541, topicName=Prostate Ca)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, createdName=30397604, createdTime=Thu Feb 06 13:09:00 CST 2020, time=2020-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1976580, encodeId=2a8419e6580f3, content=<a href='/topic/show?id=29a09340656' target=_blank style='color:#2F92EE;'>#转移性前列腺癌患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93406, encryptionId=29a09340656, topicName=转移性前列腺癌患者)], attachment=null, authenticateStatus=null, createdAvatar=, 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  6. [GetPortalCommentsPageByObjectIdResponse(id=1791593, encodeId=5a911e9159320, content=<a href='/topic/show?id=b77f14e4541' target=_blank style='color:#2F92EE;'>#Prostate Ca#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14745, encryptionId=b77f14e4541, topicName=Prostate Ca)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, createdName=30397604, createdTime=Thu Feb 06 13:09:00 CST 2020, time=2020-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1976580, encodeId=2a8419e6580f3, content=<a href='/topic/show?id=29a09340656' target=_blank style='color:#2F92EE;'>#转移性前列腺癌患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93406, encryptionId=29a09340656, topicName=转移性前列腺癌患者)], attachment=null, authenticateStatus=null, createdAvatar=, 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1616994, encodeId=43811616994e1, content=<a href='/topic/show?id=e660e3936c0' target=_blank style='color:#2F92EE;'>#社会#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73936, encryptionId=e660e3936c0, topicName=社会)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6de19781024, createdName=ms705947299214030, createdTime=Thu Nov 21 04:09:00 CST 2019, time=2019-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626666, encodeId=6ee6162666673, content=<a href='/topic/show?id=2d91449540c' target=_blank style='color:#2F92EE;'>#姑息#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44954, encryptionId=2d91449540c, topicName=姑息)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=adea21051784, createdName=经常头晕, createdTime=Thu Nov 21 04:09:00 CST 2019, time=2019-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1040594, encodeId=a16c1040594f2, content=前列腺癌相关研究,学习了,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Tue Nov 19 16:09:00 CST 2019, time=2019-11-19, status=1, ipAttribution=)]
    2019-11-21 bioon6
  7. 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createdAvatar=null, createdBy=adea21051784, createdName=经常头晕, createdTime=Thu Nov 21 04:09:00 CST 2019, time=2019-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1040594, encodeId=a16c1040594f2, content=前列腺癌相关研究,学习了,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Tue Nov 19 16:09:00 CST 2019, time=2019-11-19, status=1, ipAttribution=)]
    2019-11-21 sunylz
  8. 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  9. 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    2019-11-19 misszhang

    前列腺癌相关研究,学习了,谢谢梅斯

    0

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EPHB4受体在一些上皮肿瘤的发展过程中是具有作用的,并且是非常有前景的治疗靶标。在前列腺肿瘤中,EPHB4过表达并能够促进肿瘤发生。最近,有研究人员指出,EPHB4的高表达与前列腺癌患者的不良预后有关,EPHB4抑制能够在激素敏感性和去势抵抗性前列腺癌细胞中诱导细胞死亡。EPHB4抑制能够减少葡萄糖转运蛋白GLUT3的表达,影响葡萄糖的吸收并减少细胞ATP水平。上述过程与内质网膜应激的激活和肿瘤

Oncogene:在恶性前列腺癌中HNF1B介导的SLUG抑制受EZH2抑制

前列腺癌是发达国家最常见的恶性疾病。Zeste基因增强子同源物2(EZH2)(主要的组蛋白H3赖氨酸27甲基转移酶)的过表达与前列腺癌的恶性化有关。然而,它的下游基因和途径仍旧没有很好的建立。 最近,有研究人员阐释了肿瘤抑制子肝细胞核因子1β(HNF1B)是EZH2的直接下游把基因。在前列腺癌细胞系中,EZH2能够结合到HNF1B位点并能够抑制HNF1B的表达。上述结果进一步可以由临床样本中

院士指导,国产机器人完成首例前列腺癌根治术

近日,在海军军医大学附属长海医院泌尿外科孙颖浩院士亲自指导下,上海市东方医院团队利用机器人辅助腹腔镜下前列腺癌根治术,为一位65岁早期前列腺癌的男性患者成功进行了手术。手术历时约1.5小时。手术采用微创(上海)医疗机器人有限公司自主研发的图迈? Toumai?腔镜手术机器人。这是首例由国产腔镜机器人完成的前列腺癌根治术,由微创(上海)医疗机器人有限公司自主研发,图迈?腔镜机器人也成为中国首个完成高

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