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JCEM:血清尿酸与全因和特定病因死亡率之间的U型关联

2019-10-25 xing.T MedSci原创

由此可见,较低和较高SUA水平均与全因和特定病因死亡率增加有关,这些结果支持SUA与死亡率之间存在U型关联。

除了关于高尿酸血症与死亡率之间的关联存在争议外,低血清尿酸(SUA)与死亡率之间的关联也不确定。近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,研究人员旨在评估SUA与全因死亡率和特定原因死亡率之间的关系。

这项队列研究包含了来自NHANES研究的9118名美国成年人(1999-2002年)。多变量Cox比例风险模型用于评估SUA与死亡率之间的关系。研究人员使用的分析包括广义加性模型(GAM)和平滑曲线拟合(惩罚样条法)以及两部分式Cox比例风险模型,以解决SUA和死亡率之间的非线性问题。

在5.83年的中位随访期间,受试者发生了448起全因死亡,其中100例心血管疾病(CVD)死亡,118例癌症死亡和37例呼吸系统疾病死亡。与参考组相比,SUA处于第一和第三三分位数的参与者全因、CVD、癌症和呼吸道疾病死亡率更高。研究人员进一步发现SUA与死亡率之间存在非线性和U形关联。研究人员发现曲线的拐点处于SUA为5.7mg/dL的水平。全因死亡率的HR在拐点的左侧和右侧分别为0.80(0.65-0.97)和1.24(1.10-1.40)。在男性和女性受试者中都观察到了这种U形的关联。SUA的拐点在男性中为6mg/dL,在女性中为4mg/dL。

由此可见,较低和较高SUA水平均与全因和特定病因死亡率增加有关,这些结果支持SUA与死亡率之间存在U型关联。

原始出处:

Lihua Hu,et al.U-Shaped Association of Serum Uric Acid with All-cause and Cause-Specific Mortality in US Adults: A Cohort Study.J Clin Endocrinol Metab.2019.https://doi.org/10.1210/clinem/dgz068

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    2019-12-19 achengzhao
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    2020-03-11 smallant2015
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    2019-10-26 Dr Z

    学习了

    0

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    2019-10-26 yjs木玉

    好好好好好好

    0

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    2019-10-26 深海的鱼

    学习学习学习

    0

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    2019-10-26 飛歌

    学习了很有用不錯

    0

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