Baidu
map

JCO:乳腺癌人群C反应蛋白与放疗导致的皮肤不良反应之间的关系

2018-07-12 MedSci MedSci原创

JCO近期发表了一篇文章,研究乳腺癌人群中炎性标志物,高灵敏度C反应蛋白(hsCRP)与放疗导致的早期皮肤不良反应或毒性之间的关系。

JCO近期发表了一篇文章,研究乳腺癌人群中炎性标志物,高灵敏度C反应蛋白(hsCRP)与放疗导致的早期皮肤不良反应或毒性之间的关系。

作者分析了2001年到2013年间接受放疗的1000例乳腺癌患者,收集患者治疗前和治疗后血浆hsCRP水平,使用ONS皮肤毒性评价标准评估放疗导致的皮肤毒性。使用多因素logistic回归分析研究hsCRP水平与放疗导致的皮肤毒性之间的关系。1000例患者中包括623例白人,280例非裔美国人,64例亚洲人和33例其他种族人群。24%的患者为西班牙裔,47%的患者肥胖。约42%的患者出现放疗诱导的3级皮肤毒性,约15%的患者出现放疗诱导的4级皮肤毒性。不同人种和BMI的患者hsCRP水平显着不同。多因素分析表明,4级皮肤毒性与肥胖,放疗后hsCRP水平和两者联合显着相关。在非肥胖患者中,中位放疗后hsCRP水平以上以及hsCRP改变与4级皮肤毒性显着相关。

文章最后认为,该研究结果证明hsCRP可以作为乳腺癌放疗导致的皮肤毒性的炎症标志物。非肥胖人群hsCRP水平升高会显着增加4级皮肤毒性风险。这些结果有助于预测放疗反应及临床决策。

原始出处:

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1840564, encodeId=ce2318405649d, content=<a href='/topic/show?id=9401204912f' target=_blank style='color:#2F92EE;'>#不良反应#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20491, encryptionId=9401204912f, topicName=不良反应)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e76f39, createdName=smartjoy, createdTime=Wed Aug 29 23:45:00 CST 2018, time=2018-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1891528, encodeId=9b79189152830, content=<a href='/topic/show?id=25b0102e2df' target=_blank style='color:#2F92EE;'>#JCO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10272, encryptionId=25b0102e2df, topicName=JCO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6da1120, createdName=lidong40, createdTime=Sat Sep 29 16:45:00 CST 2018, time=2018-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=331574, encodeId=85d43315e418, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sat Jul 14 18:33:22 CST 2018, time=2018-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1297831, encodeId=14c8129e83168, content=<a href='/topic/show?id=4eca5598c7' target=_blank style='color:#2F92EE;'>#C反应蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5598, encryptionId=4eca5598c7, topicName=C反应蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=20b5274, createdName=JR19860219, createdTime=Sat Jul 14 05:45:00 CST 2018, time=2018-07-14, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1840564, encodeId=ce2318405649d, content=<a href='/topic/show?id=9401204912f' target=_blank style='color:#2F92EE;'>#不良反应#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20491, encryptionId=9401204912f, topicName=不良反应)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e76f39, createdName=smartjoy, createdTime=Wed Aug 29 23:45:00 CST 2018, time=2018-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1891528, encodeId=9b79189152830, content=<a href='/topic/show?id=25b0102e2df' target=_blank style='color:#2F92EE;'>#JCO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10272, encryptionId=25b0102e2df, topicName=JCO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6da1120, createdName=lidong40, createdTime=Sat Sep 29 16:45:00 CST 2018, time=2018-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=331574, encodeId=85d43315e418, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sat Jul 14 18:33:22 CST 2018, time=2018-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1297831, encodeId=14c8129e83168, content=<a href='/topic/show?id=4eca5598c7' target=_blank style='color:#2F92EE;'>#C反应蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5598, encryptionId=4eca5598c7, topicName=C反应蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=20b5274, createdName=JR19860219, createdTime=Sat Jul 14 05:45:00 CST 2018, time=2018-07-14, status=1, ipAttribution=)]
    2018-09-29 lidong40
  3. [GetPortalCommentsPageByObjectIdResponse(id=1840564, encodeId=ce2318405649d, content=<a href='/topic/show?id=9401204912f' target=_blank style='color:#2F92EE;'>#不良反应#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20491, encryptionId=9401204912f, topicName=不良反应)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e76f39, createdName=smartjoy, createdTime=Wed Aug 29 23:45:00 CST 2018, time=2018-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1891528, encodeId=9b79189152830, content=<a href='/topic/show?id=25b0102e2df' target=_blank style='color:#2F92EE;'>#JCO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10272, encryptionId=25b0102e2df, topicName=JCO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6da1120, createdName=lidong40, createdTime=Sat Sep 29 16:45:00 CST 2018, time=2018-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=331574, encodeId=85d43315e418, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sat Jul 14 18:33:22 CST 2018, time=2018-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1297831, encodeId=14c8129e83168, content=<a href='/topic/show?id=4eca5598c7' target=_blank style='color:#2F92EE;'>#C反应蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5598, encryptionId=4eca5598c7, topicName=C反应蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=20b5274, createdName=JR19860219, createdTime=Sat Jul 14 05:45:00 CST 2018, time=2018-07-14, status=1, ipAttribution=)]
    2018-07-14 大爰

    学习了谢谢分享!!

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1840564, encodeId=ce2318405649d, content=<a href='/topic/show?id=9401204912f' target=_blank style='color:#2F92EE;'>#不良反应#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20491, encryptionId=9401204912f, topicName=不良反应)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e76f39, createdName=smartjoy, createdTime=Wed Aug 29 23:45:00 CST 2018, time=2018-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1891528, encodeId=9b79189152830, content=<a href='/topic/show?id=25b0102e2df' target=_blank style='color:#2F92EE;'>#JCO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10272, encryptionId=25b0102e2df, topicName=JCO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6da1120, createdName=lidong40, createdTime=Sat Sep 29 16:45:00 CST 2018, time=2018-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=331574, encodeId=85d43315e418, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sat Jul 14 18:33:22 CST 2018, time=2018-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1297831, encodeId=14c8129e83168, content=<a href='/topic/show?id=4eca5598c7' target=_blank style='color:#2F92EE;'>#C反应蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5598, encryptionId=4eca5598c7, topicName=C反应蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=20b5274, createdName=JR19860219, createdTime=Sat Jul 14 05:45:00 CST 2018, time=2018-07-14, status=1, ipAttribution=)]

相关资讯

J Natl Cancer Inst:乳腺癌女性,紫杉烷诱导的神经病变的2年趋势

2018年6月,发表在《J Natl Cancer Inst》的一项由美国学者进行的研究,考察了参加乙酰-L-肉碱随机试验(SWOG S0715)的女性中,紫杉烷诱导的神经病变的2年趋势。

刘健教授:五年生存数据最接近发达国家水平,乳腺癌诊治进入慢病管理新时代

对于ER阳性/HER2阴性的晚期乳腺癌治疗,内分泌治疗是至关重要的治疗手段。最新研究发现,内分泌治疗联合靶向治疗、联合卵巢功能抑制治疗都能进一步为乳腺癌患者带来获益。随着学科的发展与综合诊治意识的提高,ER阳性/HER2阴性的晚期乳腺癌已迈入慢病管理新时代。

PNAS:哈佛大学刘小乐团队发现耐药型ER+乳腺癌的治疗新靶点

激素受体阳性(HR+)乳腺癌约占所有乳腺癌发病中的70%。大多数晚期癌症患者会对常规的内分泌疗法产生耐药性。到目前为止,人们还没有找到有效的方法来治疗耐药复发的乳腺癌病人。7月9日,寻百会生物科技的创始人、来自美国哈佛大学和Dana-Farber肿瘤研究院的科学家刘小乐教授团队,在美国科学院院刊PNAS上发表了攻克耐药型雌激素受体阳性(ER+)乳腺癌的新方法。

JAMA ONCOL:绝经前女性BMI和年龄与乳腺癌风险之间的关系

BMI增加与乳腺癌风险之间的关系很特殊,在绝经前风险下降而绝经后风险增加。在绝经前乳腺癌中这一负向关系尚未得到明确验证,但是其对理解乳腺癌发生的因果关系可能很重要。JAMA ONCOL近期发表了一篇文章,研究BMI与绝经前乳腺癌风险的关系。

J Natl Cancer Inst:TNBC:新辅助蛋白结合型紫杉醇+卡铂vs蛋白结合型紫杉醇+吉西他滨

2018年6月,发表在《J Natl Cancer Inst》的由德国学者进行的随机WSG-ADAPT-TN试验,考察了新辅助蛋白结合型紫杉醇+卡铂vs蛋白结合型紫杉醇+吉西他滨在三阴性乳腺癌(TNBC)中的有效性。

Radiology:新辅助化疗后局灶性乳腺癌晚期患者还能或多久?

本研究分析乳腺癌灌注磁共振(MR)成像中瘤内空间异质性,探究瘤内异质性预测无复发生存期(RFS)的价值,并将结果发表在Radiology上。

Baidu
map
Baidu
map
Baidu
map