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Circ Cardiovasc Imaging:房颤对ST段抬高型心肌梗死患者梗死面积和预后的影响!

2018-02-04 xing.T MedSci原创

由此可见,这项CMR研究发现ST段抬高心肌梗死或无房颤患者的心肌挽救、梗死面积或微血管损伤无显著差异。然而,房颤与心功能不全有关,与主要不良心脏事件独立相关。

房颤常见于ST段抬高心肌梗死患者,与临床结局恶化有关。然而,这种风险增加的机制尚未完全明确。最近,心血管领域权威杂志Circulation-Cardiovascular Imaging上发表了一篇研究文章。这项研究的目的是调查房颤的存在与心脏磁共振(CMR)获得的心肌挽救和损伤以及临床结局之间的关系。

这项多中心CMR研究招募了786例ST段抬高心肌梗死患者。在ST段抬高心肌梗死后3天(四分位数间距[IQR]为2-4天)评估了CMR参数(梗塞面积、心肌挽救指数、微血管阻塞和心肌功能),并比较了住院治疗期间伴有或不伴房颤的患者。通过12个月全因死亡、再梗死和新发充血性心力衰竭的复合事件来评估主要不良心脏事件。

48例(6.1%)患者患有房颤。研究人员发现组间心肌梗死面积(占左心室质量的18 [IQR为9-29]% vs. 17 [IQR为9-25]%;P=0.340)、心肌保存指数(51 [IQR为34-69] vs. 51 [IQR为33-69); P=0.830)或微血管阻塞(占左心室质量的0.6[IQR为0-2.0]% vs. 0.0 [IQR为0-1.8]%; P=0.340)没有显著相关性。房颤患者左心室(47 [IQR为34-54]% vs. 51 [IQR为44-58]%; P=0.003)和左心房(42[IQR为17-57]% vs. 53 [IQR为45-59]%; P<0.001)射血分数显著降低。房颤与主要不良心脏事件相关,即使调整临床危险因素(比值比为2.48[95%可信区间为1.22-5.03]; P=0.0120)或CMR预后标记(比值比为3.77[95%可信区间为1.83-7.79]; P=0.001)。

由此可见,这项CMR研究发现ST段抬高心肌梗死或无房颤患者的心肌挽救、梗死面积或微血管损伤无显著差异。然而,房颤与心功能不全有关,与主要不良心脏事件独立相关。

原始出处:

Sebastian J. Reinstadler,et al. Impact of Atrial Fibrillation During ST-Segment–Elevation Myocardial Infarction on Infarct Characteristics and Prognosis. Circ Cardiovasc Imaging. 2018. https://doi.org/10.1161/CIRCIMAGING.117.006955

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    2018-02-12 quxin068
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    2018-02-08 jyzxjiangqin

    房颤对ST段抬高型心梗的影响.

    0

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    2018-02-06 gdsun
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    2018-02-06 hyf035
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    2018-02-04 changjiu

    学习一下谢谢

    0

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    2018-02-04 changjiu

    学习一下谢谢

    0

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    2018-02-04 wqkm

    ^_^^_^^_^^_^

    0

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    2018-02-04 惠映实验室

    学习.谢谢分享.

    0

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