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Biofabrication: 清华大学徐弢团队首次利用微型机器人+体内生物打印治疗胃创伤

2020-08-13 转化医学网 转化医学网

为了克服这个问题,清华徐弢等开发了一种微型机器人,该机器人通过内窥镜进入人体,以在体内进行组织修复。

胃壁损伤是的常见的消化道问题,全球约有12%的人在不同程度上患有胃壁损伤。生物打印技术,将新细胞直接递送至损伤部位修复组织,这为治疗该问题提供了一种潜在的有用方法。困难在于当前的生物打印技术集中在人体外,而且生物打印机通常很大,不做有创手术就不能为内部组织修复提供足够的空间进行打印操作。为了克服这个问题,清华徐弢等开发了一种微型机器人,该机器人通过内窥镜进入人体,以在体内进行组织修复。

原位体内生物打印示意图,以治疗胃壁损伤为例

徐弢教授等科学家首先提出了原位体内生物打印的概念, 以解决传统生物打印中的现有缺陷。他们表示,通过使用微型机器人结合“原位体内生物打印”的新概念在体内进行了组织修复,已经向治疗胃创伤的新方法迈出了第一步。该研究发表在《生物制造》上。

 

在这项研究中,研究人员开发了一种可安装到内窥镜上的微型生物打印平台,用于进入人体并进行生物打印。该平台的设计和制造中采用了印刷电路、微机电系统技术。他们还开发了高精度控制系统,并进行了性能测试,以验证该平台的可行性。

 

 生物打印平台的制造

2层组织支架在胃模型打印。以人胃上皮细胞和人胃平滑肌细胞作生物墨水,用来模拟胃的解剖结构。10 d细胞培养表明,打印的细胞仍保持较高的生存能力和稳定的增殖,这表明打印的组织支架中,细胞具有良好的生物学功能。这项工作不仅在生物打印领域,而且在临床科学领域都展现了创新性的进步。

 10 d细胞培养过程中细胞形态变化的图像:显示细胞在第0天呈球形,并随着细胞的扩散和增殖逐渐变成纺锤状或菱形。

徐教授和他的博士生赵文祥开发的生物打印平台是由固定基座、移动平台和三个相同的运动链组成的Delta机器人。为了尽可能地降低侵入性,它可以在进入患者体内时折叠起来,然后在开始生物打印操作之前展开。

他们用两种方式对系统进行了测试。首先,通过人胃和内窥镜的生物学模型,模拟该过程的插入和打印操作元素。其次,他们在细胞培养皿中进行了生物打印试验,以测试该设备在生物打印活细胞和修复创面的有效性。

两项测试的结果都十分有前景。经过10天的细胞培养,打印的细胞存活率高,增殖稳定,这表明打印的组织支架中的细胞具有良好的生物学功能。

 生物打印实验设备

虽然这只是第一步,但这项研究已经证实了该概念在治疗胃壁损伤中的可行性。要使其完全实现,还需要做更多的工作,包括缩小生物打印平台的尺寸和开发生物墨水,未来的研究将集中在这些领域。

原始出处:Wenxiang Zhao and Tao Xu. Preliminary engineering for in situ in vivo bioprinting: a novel micro bioprinting platform for in situ in vivo bioprinting at a gastric wound site. Biofabrication. 12 August 2020 

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    2021-03-27 sunylz
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    2020-08-15 xue8602
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    2020-08-15 医生2397
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    2020-08-14 148b8f6am33暂无昵称

    见过徐教授,为人很好

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2004587, encodeId=90c5200458e21, content=<a href='/topic/show?id=66af505e552' target=_blank style='color:#2F92EE;'>#微型机器人#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50575, encryptionId=66af505e552, topicName=微型机器人)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1c77441, createdName=weiz, createdTime=Fri Nov 27 15:59:39 CST 2020, time=2020-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1919123, encodeId=4bf219191239f, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sat Mar 27 19:59:39 CST 2021, time=2021-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1322117, encodeId=477a132211e51, content=<a href='/topic/show?id=890c611854e' target=_blank style='color:#2F92EE;'>#机器人#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61185, encryptionId=890c611854e, topicName=机器人)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Sat Aug 15 13:59:39 CST 2020, time=2020-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1335312, encodeId=7b9c133531235, content=<a href='/topic/show?id=e7cc32022c7' target=_blank style='color:#2F92EE;'>#创伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32022, encryptionId=e7cc32022c7, topicName=创伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aa5a2500103, createdName=ms920641618706883, createdTime=Sat Aug 15 13:59:39 CST 2020, time=2020-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1500163, encodeId=c50d15001638f, content=<a href='/topic/show?id=9e6866216d7' target=_blank style='color:#2F92EE;'>#清华#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66216, encryptionId=9e6866216d7, topicName=清华)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=10f29422809, createdName=医生2397, createdTime=Sat Aug 15 13:59:39 CST 2020, time=2020-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1583259, encodeId=1bb01583259c0, content=<a href='/topic/show?id=f6e1611840d' target=_blank style='color:#2F92EE;'>#机器#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61184, encryptionId=f6e1611840d, topicName=机器)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=13dc16973127, createdName=ms6279672939590805, createdTime=Sat Aug 15 13:59:39 CST 2020, time=2020-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=808727, encodeId=11c9808e276c, content=见过徐教授,为人很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211022/94f62262d8244456b1c529163b0f2461/053cdbaf3ef746858b8c0841c78173e5.jpg, createdBy=8a0a5325209, createdName=148b8f6am33暂无昵称, createdTime=Fri Aug 14 06:44:58 CST 2020, time=2020-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=808640, encodeId=62bd808640e5, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Thu Aug 13 23:20:40 CST 2020, time=2020-08-13, status=1, ipAttribution=)]
    2020-08-13 zb1235672

    学习了

    0

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