Braz J Psychiatry：舌下含服和口服唑吡坦可有效治疗失眠症

2020-10-05 MedSci原创 MedSci原创

本研究旨在评估5毫克舌下含服剂量的唑吡坦与10毫克口服剂量相比，在睡前和半夜醒来后 "按需 "服用的安全性和有效性，研究结果已在线发表于Braz J Psychiatry。

本研究旨在评估5毫克舌下含服剂量的唑吡坦与10毫克口服剂量相比，在睡前和半夜醒来后 "按需 "服用的安全性和有效性，研究结果已在线发表于Braz J Psychiatry。

参与者被随机分为口服组（口服唑吡坦10毫克和舌下安慰剂在睡前和 "按需"）和舌下组（口服安慰剂和舌下唑吡坦5毫克在睡前和 "按需"）。参与者接受了医学评估、多导睡眠图、精神运动警觉性测试，并填写了问卷。

85名患者中，67名符合失眠标准（48±10岁；79%为女性），并被随机分组。其中，46人完成92±5天的治疗。25%的参与者报告了轻度到中度的不良事件，包括头痛、困倦和头晕。两种治疗均使半夜觉醒天数平均减少-3.1±2.3天/周，总睡眠时间增加1.5小时。睡眠质量和失眠严重程度评分的变化也得到改善，组间具有可比性：差异取决于继续治疗的情况。关于PSG结果，舌下组的睡眠潜伏期比口服组减少更多（-14±42 vs. 10±29分钟；P = 0.03）。心理运动警觉性测试在觉醒后30分钟出现轻微的残留效应，2小时后恢复。

综上所述，该研究结果表明，两种唑吡坦制剂的安全性和有效性相当。舌下含服5mg剂量诱导睡眠更迅速。

原始出处：

Laura S Castro, Leonardo J Otuyama, et al., Sublingual and oral zolpidem for insomnia disorder: a 3-month randomized trial. Braz J Psychiatry. 2020 Apr;42(2):175-184. doi: 10.1590/1516-4446-2019-0389.

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2021-07-04 diushouji

#Psychiatry#

77 0
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2021-03-26 898319336

学习

112 0
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2021-04-20 12498e5fm22(暂无昵称)

#AZ#

76 0
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2020-10-07 刘煜

阅读谢谢分享

0 0
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2020-10-06 日月

#失眠症#

140 0
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2020-10-06 周虎

#唑吡坦#

86 0
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2020-10-06 循证小兵

#舌下含服#

83 0
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2020-10-06 docwu2019

#有效治疗#

99 0

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Braz J Psychiatry：舌下含服和口服唑吡坦可有效治疗失眠症

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