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胞浆蛋白核转移让致命儿童脑瘤恶性程度更高

2016-10-05 佚名 生物谷

儿童脑瘤
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一些恶性的成神经细胞瘤在细胞核内存在一种特殊蛋白，而在一些良性的成神经细胞瘤的细胞核中并不存在，美国罗切斯特大学医学中心的研究人员通过研究得到了上述发现，这项发现将促进新靶向治疗方法的开发。EYA1是一个能够促进耳朵发育的蛋白，也出现在许多成神经细胞瘤的细胞质中，但是这种蛋白会在一些恶性的成神经细胞瘤细胞中向细胞核内迁移。这项研究最近发表在两个医学研究杂志上，有助于开发一些靶向药物用于阻止成神经细


一些恶性的成神经细胞瘤在细胞核内存在一种特殊蛋白，而在一些良性的成神经细胞瘤的细胞核中并不存在，美国罗切斯特大学医学中心的研究人员通过研究得到了上述发现，这项发现将促进新靶向治疗方法的开发。

EYA1是一个能够促进耳朵发育的蛋白，也出现在许多成神经细胞瘤的细胞质中，但是这种蛋白会在一些恶性的成神经细胞瘤细胞中向细胞核内迁移。这项研究最近发表在两个医学研究杂志上，有助于开发一些靶向药物用于阻止成神经细胞瘤发展到更加恶性的阶段。研究人员已经在实验室内开始对一些治疗方法进行检测。

"成神经细胞瘤是最常见也是最致命的一种儿童癌症，这项发现帮助我们发现了一些能够阻止EYA1结构改变的药物，有助于减小患儿的危险程度。"Nina Schor教授这样说道。

EYA1蛋白进入癌细胞的细胞核是由于PRMT1这个酶的出现。这种酶也会增加另外一种蛋白的表达，N-MYC，该蛋白一直都被认为能够增加成神经细胞瘤的恶性程度。

因此通过限制PRMT1的活性，研究人员认为他们能够同时降低上述两种蛋白造成的损伤。"PRMT1抑制剂可能会在成神经细胞瘤的恶性程度变得更高之前达到一种一箭双雕的效果。"Schor这样说道。

相关研究结果发表在国际学术期刊Journal of Cancer Research ＆ Therapy 和Oncotarget上。

原始出处

Allison Eberhardt, Jeanne N. Hansen, Jan Koster, Louis T. Lotta Jr, Simeng Wang, Emmett Livingstone, Kun Qian, Linda J. Valentijn, Yujun George Zheng, Nina F. Schor, Xingguo Li.Protein arginine methyltransferase 1 is a novel regulator of MYCN in neuroblastoma.

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    2016-10-11 知难而进

    继续关注！

    0

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    2016-10-11 知难而进

    谢谢分享！

    0

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    2016-10-07 jxrzshh

    #脑瘤#

    0

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    2016-10-06 医路开来

    謝謝分享，，

    0

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    2016-10-06 医路开来

    學習啦，，

    0

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英国GW制药公司近日公布了大麻提取物Epidiolex（cannabidiol，大麻二醇，CBD）治疗Lennox-Gastaut综合征（LGS）的第二个随机、双盲、安慰剂对照III期临床研究的积极数据。LGS是一种罕见的、严重的、难治性儿童期发作癫痫。该项研究中的患者之前已尝试过平均7种抗癫痫药物，目前正在接受平均3种药物治疗。 研究中，将安慰剂或Epidiolex添加至患者当前的治疗方案

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由此可见，中段ProANF能精确检测儿童和青少年中的心衰患者，其诊断性能与NT-proBNP媲美。

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