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BMJ新闻:儿童出生后第1年的体重增加与日后1型糖尿病的发生有关

2015-12-08 sunshine译 MedSci原创

据发表于JAMA Pediatric的一项研究表明,儿童出生后1年的体重变化与其日后1型糖尿病的发生之间存在正相关关系。

据发表于JAMA Pediatric的一项研究表明,儿童出生后1年的体重变化与其日后1型糖尿病的发生之间存在正相关。

该研究共包括了59221名来自挪威母亲和儿童队列研究的儿童以及40611名来自丹麦全国出生队列研究的儿童。随访结束时来自挪威的研究对象平均年龄为8.6岁,来自丹麦的研究对象平均年龄为13岁。

丹麦1型糖尿病的发病率为25/100000,挪威为31/100000。儿童出生后第一年内体重的变化平均为6公斤。该研究发现,儿童出生后1年体重的增加量与日后1型糖尿病的诊断成正相关。校正潜在的混杂因素,包括出生体重、身长、母乳喂养时间以及母亲的年龄和BMI后,二者之间仍存在此种关联。儿童出生后1年身体的增长与日后糖尿病的诊断之间并未发现存在明显地相关关系。

既往研究已经表明,儿童早期的生长或与1型糖尿病的发生有关,但是大部分研究为回顾性研究或研究对象仅限于1型糖尿病高风险人群。而此项研究是探究儿童出生后1年与日后1型糖尿病的发生存在关联的第一个基于人群的前瞻性研究。但是研究人员承认,任何观察性研究都可能存在混杂因素。他们推测,儿童身体的快速增长增加了对分泌胰岛素的细胞的需求,而这些细胞可能更容易受到细胞因子的影响。

原始出处:

Jacqui Wise. Weight increase in first year of life linked to type 1 diabetes. BMJ 2015;


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    2016-04-02 gaoxiaoe
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    2015-12-23 xiaotaiyang1

    小胖孩值得关注

    0

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    2015-12-09 鲜花飞鸟

    这都能被你们发现和研究出来,也是无话可说

    0

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    2015-12-09 老段

    真?假?

    0

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    2015-12-09 xi.xiong

    糖尿病还真是现在小孩必须关注的话题!

    0

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