J Exp Clin Cancer Res：研究进一步揭示肝细胞癌进展的机制

2017-09-08 MedSci MedSci原创

肝细胞癌（HCC）对化疗的总体反应率很低。本实验组既往研究发现，奥沙利铂耐药性增强，且CCN2和LRP6的水平增加，而CCN2及LRP6在肝细胞癌患者预后中的作用，且CCN2与LRP6的相互作用调控机制目前仍不清楚。研究人员在肝癌患者中检测了CCN2与LRP6基因的表达水平，并在体内外对CCN2和LRP6的基因功能进行了分析。证实HCC中细胞表面的硫酸肝素蛋白多糖（HSPGs）在CCN2和LRP6

肝细胞癌（HCC）对化疗的总体反应率很低。本实验组既往研究发现，奥沙利铂耐药性增强，且CCN2和LRP6的水平增加，而CCN2及LRP6在肝细胞癌患者预后中的作用，且CCN2与LRP6的相互作用调控机制目前仍不清楚。

研究人员在肝癌患者中检测了CCN2与LRP6基因的表达水平，并在体内外对CCN2和LRP6的基因功能进行了分析。证实HCC中细胞表面的硫酸肝素蛋白多糖（HSPGs）在CCN2和LRP6之间的相互调节作用，并探究低分子肝素钠（LMWH）的干预作用。

结果显示，HCCs患者中CCN2和LRP6过度表达，且CCN2和LRP6的水平与HCCs的恶性表型及较差的预后相关。LRP6可显著上调CCN2得表达水平。同时，通过结合LRP6，CCN2能够以剂量依赖的方式增强肝癌细胞的恶性表型；敲除LRP6，扰动HSPGs，CCN2与LMWH一起能显著阻断CCN2与LRP6的结合。LMWH增强奥沙利铂对肝癌的治疗效果，同时CCN2的表达升高。

总之，该研究结果表明，通过激活LRP6 CCN2可以HSPGs依赖性方式促进HCC的进展。肝素与化疗联合应用可产生协同效应，且高表达CCN2或可作为 HCCs治疗的选择。

原始出处：

Qingan Jia, Yang Bu, et al., Maintenance of stemness is associated with the interation of LRP6 and heparin-binding protein CCN2 autocrined by hepatocellular carcinoma. J Exp Clin Cancer Res. 2017; 36: 117. Published online 2017 Sep 4. doi: 10.1186/s13046-017-0576-3

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2018-04-30 qingting

#细胞癌#

79 0
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2018-04-03 xjy02

#肝细胞#

64 0
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2017-09-12 ylzr123

感谢小编为我们准备了如此丰盛的精神大餐.同时也向作者致谢!认真学习了.点赞!

78 0
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2017-09-10 yfjms

学习了

84 0
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2017-09-09 luominglian113

学习了.谢谢分享

101 0
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2017-09-09 明天会更好！

不错的文章.值得一读

67 0
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2017-09-08 往日如昨

继续学习中谢谢

0 0
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2017-09-08 往日如昨

学习了谢谢分享

69 0
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2017-09-08 怡航云

现在我的母亲是肺癌晚期低分化可以PD1这种药吗?

61 0
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2017-09-08 1ddf0692m34(暂无匿称)

学习了.涨知识

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