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Osteoporos Int:户外空气污染导致髋部骨折风险升高?

2018-11-22 吴星 环球医学

发表于《Osteoporos Int》上的一项研究,考察了南欧地区不同空气污染物水平与骨质疏松性髋部骨折发生率间的相关性,SO2和NO2与髋部骨折之间的相关性。

发表于《Osteoporos Int》上的一项研究,考察了南欧地区不同空气污染物水平与骨质疏松性髋部骨折发生率间的相关性,SO2和NO2与髋部骨折之间的相关性。

目的:旨在检测南欧地区户外空气污染对骨质疏松性髋部骨折发生率的短期影响。

方法:这是基于从3个数据库中获取的数据进行的一项生态回顾性队列研究。在时间序列分析中,研究者使用广义加法模型(泊松分布)检测了髋部骨折发生率和不同户外空气污染物(二氧化硫(SO2)、一氧化氮(NO)、二氧化氮(NO2)、臭氧(O3)、直径<2.5和10μm的颗粒物(PM2.5,PM10))状态之间的相关性。对所有空气污染物估计了发生率比(IRR)、粗发生率比和根据季节和不同天气条件调整后的发病率比(IRR)。之后,研究者分析了性别和年龄(低于和超过75岁)亚组的髋部骨折发生率。主要结局测量为每天骨折住院率。

结果:SO2(IRR,1.11;95% CI,1.04~1.18)、NO(1.01;1.01~1.02)、NO2(1.02;1.01~1.04)与髋部骨折发生率具有相关性。对于臭氧水平,该相关性为阴性(0.97;0.95~0.99)。当根据季节调整模型时,SO2和NO2的相关性继续维持。根据季节和天气状态调整后,NO2的相关性保持。当根据年龄和性别对参与者进行分层时,仅在75岁以上的女性中持续该相关性。

结论:空气污染对髋部骨折发生率的几项指标都观察到了短期相关性。这是表明这些相关性的首项研究。

原始出处
Mazzucchelli R1, Crespi Villarias N2, Perez Fernandez E3,et al.Short-term association between outdoor air pollution and osteoporotic hip fracture.Osteoporos Int. 2018;29(10):2231-2241. doi: 10.1007/s00198-018-4605-7.

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    2018-11-24 lsndxfj
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    2018-11-24 liuquan
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