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Eur Heart J:这种干细胞技术或可通过扭转老化心脏而延长寿命!

2017-08-15 sunshine2015 来宝网

来自加利福尼亚州洛杉矶的雪松 - 西奈心脏研究所的研究人员发现,从新生儿心脏注射的专门的干细胞注射到老年鼠体内似乎恢复了老年动物的心脏功能。

【专门的干细胞可以扭转年老的心脏】新的研究表明,年轻的心脏干细胞可能能够恢复老化的心脏,甚至可能扭转其他衰老迹象。

来自加利福尼亚州洛杉矶的雪松 - 西奈心脏研究所的研究人员发现,从新生儿心脏注射的专门的干细胞注射到老年鼠体内似乎恢复了老年动物的心脏功能。

治疗改善心脏功能,增加运动能力,并逆转几种老化的生物标志物。

在过去的一百年中,全球人类的预期寿命已经有了显着的改善。不久之后,世界将有更多的老年人。

这样的人口转型给医学带来了新的挑战。如今,即使在较贫穷的国家,大多数老年人死于心脏病,糖尿病,癌症和其他非传染性疾病,而不是传染病和寄生虫病。

在美国,心脏病是男性和女性死亡的主要原因。

人口老化的另一个特点是患有多于一个健康问题的人群的增加,例如糖尿病和心脏病。

血管疾病和衰老

研究人员在他们的研究报告中指出,随着年龄的增长,心血管疾病的发病率显着增加,并且讨论了老化心脏发生的情况。

例如,随着心脏衰老,它变得更僵硬,更不能放松,从而增加心力衰竭的风险。

作者还讨论了心脏衰老时心脏细胞发生的情况。他们提到的一个特征是渐进缩短,细胞分裂,端粒,这是保护染色体末端的“帽”。

研究人员解释说,端粒的“临界缩短”与许多随年龄增长的心脏问题相关联,如心脏功能障碍。

一些“复兴的策略” - 包括输入年轻血液和重新编程细胞 - 已经显示出应对这些问题的希望,作者提到,但没有一个“解决与年龄有关的心脏功能障碍”的方法。

改善心脏功能

研究人员调查从实验室饲养的新生大鼠采集心源性细胞,并将其注入大约22个月龄的老年大鼠的心脏。

心源性细胞来源的细胞是可以成熟为心脏细胞,心肌细胞,内皮细胞和平滑肌细胞三种主要类型之一的未成熟细胞。

该小组还治疗了同一年龄的另一组大鼠,作为对照组,用盐水注射代替心源性细胞。然后他们将这两组与年龄约4个月的老鼠进行比较。

在治疗前,在基线时,大鼠进行心脏功能,运动能力和各种血液标志物的测试。然后在治疗后一个月重复测试。

之前和之后测试的比较显示不仅在心脏本身,而且在其他标志物中有改善的迹象。

例如,与用盐水处理的对照大鼠相比,接受年轻心源性细胞的大鼠显示改善的舒张功能。健康的舒张功能可以使心脏放松,充满血液,准备好抽吸。

“复兴囊泡”

用专门的干细胞治疗的老鼠也在其心脏细胞中具有更长的端粒,表明它们的心脏比对照大鼠的老化年龄更小。

最后,与没有接受年轻细胞的老鼠相比,治疗的大鼠也将运动能力提高了20%。

仔细检查后,该团队发现了一种可能的解释,说明了心源性细胞的复兴效果。

资深作家EduardoMarbán解释说:“他们分泌了充满信号分子如RNA和蛋白质的小囊泡,”Cedars-Sinai心脏研究所主任医师教授EduardoMarbán解释说。他补充说:“年轻细胞的囊泡似乎包含了所有必要的指示来扭转老化。”

研究人员指出,将来的研究将取决于心源性细胞治疗是否延长寿命。

他们的团队表示,未来的研究必须旨在找出细胞是否必须来自一个年轻的捐助者,以及细胞的所有恢复活力是否来自囊泡。

“我们以前的实验室研究和人体临床试验已经显示出使用心脏干细胞输注治疗心力衰竭的前景,现在我们发现这些专门的干细胞可能会扭转与心脏老化有关的问题。

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    2017-08-17 zhaojie88
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  4. [GetPortalCommentsPageByObjectIdResponse(id=2079668, encodeId=c92e20e966854, content=<a href='/topic/show?id=a87448e7286' target=_blank style='color:#2F92EE;'>#干细胞技术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48772, encryptionId=a87448e7286, topicName=干细胞技术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b79433, createdName=jiangjun073, createdTime=Sun Jun 03 05:48:00 CST 2018, time=2018-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356467, encodeId=b377135646e09, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Aug 17 01:48:00 CST 2017, time=2017-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1388006, encodeId=986b13880063c, content=<a href='/topic/show?id=18b3800914e' target=_blank style='color:#2F92EE;'>#老化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80091, encryptionId=18b3800914e, topicName=老化)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/4v5DMqK7WnzoBdibNsryQ8OEM5gFSdRH9j3HNCKPfKXlObInweOSHdQPATeTicYp7nvg3bsgicjLgRkdlhrpry21w/132, createdBy=6bf82500013, createdName=ms5822920152752585, createdTime=Thu Aug 17 01:48:00 CST 2017, time=2017-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479851, encodeId=1a4314e985119, content=<a href='/topic/show?id=456b4954350' target=_blank style='color:#2F92EE;'>#延长寿命#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49543, encryptionId=456b4954350, topicName=延长寿命)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d9587588723, createdName=hittouch, createdTime=Thu Aug 17 01:48:00 CST 2017, time=2017-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562662, encodeId=203a1562662cf, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Thu Aug 17 01:48:00 CST 2017, time=2017-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233805, encodeId=826e233805a6, content=非常好的文章,学习了,很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Tue Aug 15 12:14:48 CST 2017, time=2017-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233796, encodeId=d5f2233e9600, content=干细胞治疗心脏病,或收效。, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Tue Aug 15 11:05:44 CST 2017, time=2017-08-15, status=1, ipAttribution=)]
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    2017-08-17 slcumt
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    2017-08-15 天涯183

    非常好的文章,学习了,很受益

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2079668, encodeId=c92e20e966854, content=<a href='/topic/show?id=a87448e7286' target=_blank style='color:#2F92EE;'>#干细胞技术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48772, encryptionId=a87448e7286, topicName=干细胞技术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b79433, createdName=jiangjun073, createdTime=Sun Jun 03 05:48:00 CST 2018, time=2018-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356467, encodeId=b377135646e09, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Aug 17 01:48:00 CST 2017, time=2017-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1388006, encodeId=986b13880063c, content=<a href='/topic/show?id=18b3800914e' target=_blank style='color:#2F92EE;'>#老化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80091, encryptionId=18b3800914e, topicName=老化)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/4v5DMqK7WnzoBdibNsryQ8OEM5gFSdRH9j3HNCKPfKXlObInweOSHdQPATeTicYp7nvg3bsgicjLgRkdlhrpry21w/132, createdBy=6bf82500013, createdName=ms5822920152752585, createdTime=Thu Aug 17 01:48:00 CST 2017, time=2017-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479851, encodeId=1a4314e985119, content=<a href='/topic/show?id=456b4954350' target=_blank style='color:#2F92EE;'>#延长寿命#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49543, encryptionId=456b4954350, topicName=延长寿命)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d9587588723, createdName=hittouch, createdTime=Thu Aug 17 01:48:00 CST 2017, time=2017-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562662, encodeId=203a1562662cf, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Thu Aug 17 01:48:00 CST 2017, time=2017-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233805, encodeId=826e233805a6, content=非常好的文章,学习了,很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Tue Aug 15 12:14:48 CST 2017, time=2017-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233796, encodeId=d5f2233e9600, content=干细胞治疗心脏病,或收效。, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Tue Aug 15 11:05:44 CST 2017, time=2017-08-15, status=1, ipAttribution=)]
    2017-08-15 1e0f8808m18(暂无匿称)

    干细胞治疗心脏病,或收效。

    0

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目的:据报道,低睾酮水平与充血性心衰风险增加相关,但是其作用机制尚不清楚。研究者旨在评估1型糖尿病男性患者内源性睾酮和心脏质量和功能的关系。设计:一项前瞻性观察研究的二次分析。参与者:在糖尿病干预和并发症的流行病学研究(EDIC)中的男性(n = 508),观察随访糖尿病控制和并发症试验。测量:EDIC10年应用液相色谱-质谱法评估睾酮水平,EDIC14 / 15年时进行心脏磁共振CMR检查。在校

Crit Care Med:创伤性脑损伤可以影响心脏收缩功能

此前有研究表明,创伤性脑损伤可能会影响心脏功能。近期,一项发表在杂志Crit Care Med上的研究旨在确定中重度创伤性脑损伤患者发生收缩功能障碍的频率、进程和入院的危险因素。此项研究为前瞻性队列研究。在中重度创伤性脑损伤后1天内和第1周内进行经胸超声心动图检查;轻度创伤性脑损伤后1天内进行经胸超声心动图(对照组)。通过经胸超声心动图评估心脏收缩功能,收缩功能障碍定义为射血分数小于25%。多变量

Am J Respir Crit Care Med:COPD药物治疗对心肺血管和功能都有有利影响

基本原理:慢性阻塞性肺疾病患者因结构改变可增加心血管疾病的发病。目标:这项双盲,安慰剂对照,交叉研究探讨肺收缩对心血管结构和功能的影响,应用心脏磁共振检查肺的心血管结构和功能。方法:45个慢性阻塞性肺疾病患者随机(1:1)到7天(最大14天)吸入糖皮质激素/长效β2-受体激动剂糠酸氟替卡松/维兰特罗100 / 25μg或安慰剂(7天)。主要预后:与安慰剂相比,右心室舒张末期容积指数的变化。主要结果

Am J Kidney Dis:CKD儿童和青少年胱抑素C与心脏功能相关

轻中度CKD的儿童和青少年其胱抑素C水平与心脏结构和左室舒张功能独立相关。调整了mGFR后,胱抑素C水平仍然能够通过E′/A′比预测舒张功能下降,这表明胱抑素C水平在CKD的儿童和青少年CVD危险分层中可能存在独立的作用。

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