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血栓弹力图,“弹”的是什么?

2020-08-16 杜娜 检验医学网

在门诊时经常会有病人拿着血栓弹力图的化验报告过来咨询,“大夫,我得没得血栓啊?严不严重啊?”普罗大众对于血栓弹力图的认知都是从字面意思来理解,今天我们就来谈谈血栓弹力图到底&l

在门诊时经常会有病人拿着血栓弹力图的化验报告过来咨询,“大夫,我得没得血栓啊?严不严重啊?”普罗大众对于血栓弹力图的认知都是从字面意思来理解,今天我们就来谈谈血栓弹力图到底“弹”的是什么。

首先血栓弹力图(thrombelastogram,TEG)是血栓弹力仪描绘出的凝血动态过程曲线。用于评价人凝血及纤溶系统的功能,提示患者的真实凝血情况。采血管中枸橼酸根与血中钙离子形成难解离的络合物,钙离子是凝血过程中必需的物质之一,血液中钙离子减少,从而血液凝固受阻。在样品测定杯中加入CaCl2及促进剂,血液便开始凝结,随后出现纤溶过程。通过血栓弹力图仪测定杯体和杯盖间产生的切应力,就能描绘出血块强度随时间变化的曲线。

血栓弹力图的主要指标有:

①凝血时间(R)为血样加入测试杯开始计时,到曲线开口振幅达2mm时的时间。

②血块成形时间(K)是指从测量R时间的时间起点(血凝块开始形成)至血凝块硬度达到某一固定水平(振幅=20mm)的时间。

③血块强度(MA)为血栓弹力图曲线开口达到最大时曲线开口之间的距离。

④血凝速率(Angelα)是以曲线开口为起点,做曲线的切线与水平的夹角。

⑤凝血综合指数(CI)为R,K,α,MA计算得出的结果。

各项指标的临床指导意义

R时间:反眏内、外源性和共同道路,以及纤维蛋白原被激活形成纤维蛋白网开始的情况,是检测凝血因子的一个指标。

R值范围:5~10min;R<5min,说明凝血因子活性强,需要用抗凝药物纠正。R>10min,说明凝血因子缺乏。

K时间:反映纤维蛋白和血小板在血凝块开始形成时的共同作用结果,即血凝块形成的速率,由于此时以纤维蛋白的功能为主,故为检测纤维蛋白原功能的一个指标。

K值正常范围:1min<K<3min,53°<Angel<72°。当K>3min/Angel<53°时:说明纤维蛋白原功能偏低,当K<1min/Angel>72°时:说明纤维蛋白原功能偏高。

Angle夹角(a):意义同K值,也是检测纤维蛋白原功能的一个指标。Angel值正常范围:53°<Angel<72°。

Cl综合凝血指数:综合评价凝血的参数,对于血栓和出血的预测具有意义,CI值正常范围:-3<CI<+3。CI值<-3:低凝,-3<正常<+3,CI值>+3:高凝。

MA:临床检测血小板质量的一个指标,MA值正常范围:50-70mm。MA>70,显示血小板活性高,需进行抗血小板治疗。

MA<50,显示低血小板功能,如病人术中出血可通过补充血小板制剂纠正,详见输血指导建议。

LY30纤溶率:检测纤溶的一个指标,LY30值正常范围:0%-8% 。LY30>8%,表示处于高纤溶状态。

 

综上所述,血栓弹力图检测(普通杯法)主要用于:

  • 评估凝血全貌,判断凝血状态;
  • 指导各种成分输血和相关药物使用;
  • 区分原发和继发纤溶亢进;
  • 判断促凝和抗凝等药物的疗效如比伐卢定、抗Xa、重组VII因子等;
  • 评估血栓几率,预防手术后的血栓发生。

血栓弹力图试验由于涵盖内、外源性凝血通路和纤维蛋白溶解系统等综合因素,可以帮助做出整理倾向上的判断以及个体化,个性化的凝血分析。是符合临床需求的、更全面、更具体的基础凝血检测。

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    2022-10-15 孙羲和

    讲的很详细,清晰易懂

    0

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    2021-11-10 芳芳要加油呀

    学习了

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2093889, encodeId=134e209388993, content=讲的很详细,清晰易懂, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20221015/7e7192f7e99647068d90397a1bff0b91/12e917b1a9cf4cdb963692433a16aebd.jpg, createdBy=7a2c8377794, createdName=孙羲和, createdTime=Sat Oct 15 09:27:31 CST 2022, time=2022-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1068999, encodeId=bd7e10689993a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae6c5608723, createdName=芳芳要加油呀, createdTime=Wed Nov 10 15:56:57 CST 2021, time=2021-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=883132, encodeId=52c48831325b, content=长知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=044a5416161, createdName=ms6000002071701007, createdTime=Sun Sep 06 19:00:08 CST 2020, time=2020-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=810971, encodeId=d16c8109e15a, content=👍, beContent=null, objectType=article, channel=null, level=null, likeNumber=174, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=25e55411955, createdName=ms5000000741733160, createdTime=Wed Aug 19 16:09:10 CST 2020, time=2020-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=810600, encodeId=0327810600df, content=涨知识了,好, beContent=null, objectType=article, channel=null, level=null, likeNumber=181, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cbef5132349, createdName=蔡冬里蔡, createdTime=Wed Aug 19 07:08:46 CST 2020, time=2020-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=810540, encodeId=7095810540f4, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=186, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fb682417917, createdName=1238d654m87暂无昵称, createdTime=Tue Aug 18 21:44:34 CST 2020, time=2020-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=810305, encodeId=92ef810305f5, content=涨知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=207, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b7d95410991, createdName=ms6000001655887159, createdTime=Tue Aug 18 14:24:18 CST 2020, time=2020-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=809924, encodeId=3d7e8099242a, content=学习了,, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/udqvoAsWtvRVficPKOpMh4M31O9bJ8jMiaUHAheeNpIqMapC8mUnBWfEskrcVjofbicWU4icRD6vFvVeEYlPmSbXELickazEGVFYO/0, createdBy=24741603767, createdName=医艺依意, createdTime=Mon Aug 17 22:57:05 CST 2020, time=2020-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=809819, encodeId=8d02809819b3, content=学习了,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzTetibytbqFDmFITWHyBWbxU7S9MYibgPSqvu0sYteH0N6zXqbU0Kf3Mbdb7yWM1Kud3zPgYBibE2SZ/0, createdBy=da7696924, createdName=qingfengqishi5, createdTime=Mon Aug 17 20:16:32 CST 2020, time=2020-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=809667, encodeId=d98080966e9b, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200817/2786f976001a4edd9a06b98ec2527751/bef891b389dd48d8a0076e15cba6fc86.jpg, createdBy=72015403602, createdName=ms5000001908858550, createdTime=Mon Aug 17 13:10:26 CST 2020, time=2020-08-17, status=1, ipAttribution=)]
    2020-09-06 ms6000002071701007

    长知识了

    0

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    2020-08-19 ms5000000741733160

    👍

    0

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    2020-08-19 蔡冬里蔡

    涨知识了,好

    0

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    2020-08-18 ms6000001655887159

    涨知识了

    0

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    2020-08-17 医艺依意

    学习了,

    0

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    2020-08-17 qingfengqishi5

    学习了,学习了

    0

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    2020-08-17 ms5000001908858550

    0

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