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Diabetes Care:孕早期腹部脂肪,有助于妊娠期糖尿病高危人群的识别

2015-11-08 Seven L 译 MedSci原创

最新研究表明,孕早期腹部脂肪的增加或导致妊娠期糖尿病风险的增加。该研究纳入了500名女性,年龄18-42岁,通过超声测量孕11-14周的腹部脂肪情况。数据显示腹部脂肪越多的女性在孕24-28周诊断为妊娠期糖尿病的可能性越大。但是该研究仅仅提供了两者间的相关性,并不是因果性。该研究强调了孕早期的筛查,通过腹部脂肪预测糖尿病发生情况。仅仅在常规产前检查的时候,留意下孕早期女性腹部脂肪情况,就可以识别妊

最新研究表明,孕早期腹部脂肪的增加或导致妊娠期糖尿病风险的增加。

该研究纳入了500名女性,年龄18-42岁,通过超声测量孕11-14周的腹部脂肪情况。数据显示腹部脂肪越多的女性在孕24-28周诊断为妊娠期糖尿病的可能性越大。但是该研究仅仅提供了两者间的相关性,并不是因果性。

该研究强调了孕早期的筛查,通过腹部脂肪预测糖尿病发生情况。仅仅在常规产前检查的时候,留意下孕早期女性腹部脂肪情况,就可以识别妊娠期糖尿病风险人群。而目前临床上对该疾病的筛查是孕中期或孕晚期。

大约有60%的女性在妊娠期会超重,很多女性分娩时处于高龄,大多数人的家族史有2型糖尿病患者。所以年龄、种族、家族史、体重等传统危险因素会导致越来越多的人纳入高危组,导致临场上对真正的高危人群识别困难。

先前有研究表明,妊娠期糖尿病患者中有20%-50%的人群在分娩后5年发展为2型糖尿病。目前可以通过合理饮食+运动组织腹部脂肪增长过快,缓解妊娠期糖尿病风险。

原始出处:

De Souza LR, Berger H, et al.First-Trimester Maternal Abdominal Adiposity Predicts Dysglycemia and Gestational Diabetes Mellitus in Midpregnancy.Diabetes Care. 2015 Nov 2.

Belly Fat Linked to Gestational Diabetes Risk.Medscape.Nov,2015

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高危孕妇妊娠期糖尿病是可以预防的世界范围内,肥胖和超重的发病率一直在上升,发达国家中存在高达60%的育龄妇女超重或肥胖。肥胖是妊娠并发症(如妊娠期糖尿病GDM)的危险因素,而GDM发过来又可预测未来糖尿病的发生。妊娠期糖尿病及孕妇肥胖还可能增加其后代肥胖的易感性,并损伤机体的糖调节功能。因此,亟需一种有效干预措施以预防GDM的发生。然而,既往GDM预防研究的结果并不一致,对GDM发病率的影响也较小

Acta Diabetol:指血糖筛查妊娠期糖尿病

Bhavadharini B等人进行了一项研究,目的是评估在不能检测静脉血浆葡萄糖含量(VPG)的资源受限区域,通过指血糖(CBG)诊断妊娠期糖尿病(GDM)的有效性。该研究纳入了1031名孕妇,均参加了印度南部关于GDM筛查的产前诊断项目——口服75g葡萄糖耐量试验(75gOGTT),同时检测了空腹血糖、餐后1小时血糖、餐后2小时血糖的VPG和CBG。使用国际妊娠期间糖尿病协会学习小组(IADP

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