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JACC:PET可以预测心肌淀粉样变性患者的预后

2020-02-14 不详 MedSci原创

目前,对于心肌淀粉样沉积程度的非侵入性评估是否能预测轻链(AL)心肌淀粉样变性患者的预后尚不清楚。本研究的目的旨在评估11C-PiB PET是否能预测AL心肌淀粉样变性的预后。本研究纳入分析了41名AL心肌淀粉样变性患者,主要终点事件是全因死亡、心脏移植和急性心衰的复合事件。分析结果显示,相比于对照,11C-PiB PET的摄入在心肌淀粉样变性患者中更高,并与免疫组化的淀粉沉积程度相符。在平均42

目前,对于心肌淀粉样沉积程度的非侵入性评估是否能预测轻链(AL)心肌淀粉样变性患者的预后尚不清楚。本研究的目的旨在评估11C-PiB PET是否能预测AL心肌淀粉样变性的预后。

本研究纳入分析了41名AL心肌淀粉样变性患者,主要终点事件是全因死亡、心脏移植和急性心衰的复合事件。分析结果显示,相比于对照,11C-PiB PET的摄入在心肌淀粉样变性患者中更高,并与免疫组化的淀粉沉积程度相符。在平均423天的随访时间里,24名患者发生了主要终点事件。11C-PiB PET的摄入越高的患者生存率越低,多变量回归分析模型中,11C-PiB PET的摄入量是心肌淀粉样变性患者预后的独立预测因子。

研究结果显示,心肌淀粉沉积的非侵入性评估可以真实反映AL心肌淀粉样变性患者的心肌淀粉沉积程度,是患者预后的独立预测因子。

原始出处:

本文系梅斯医学(MedSci)原创编译整理,转载需授权


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    2020-08-14 feather89
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    2020-10-28 hbwxf
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    2020-02-16 huangdf

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心肌纤维化是主动脉瓣狭窄患者左室失代偿的主要机制,且可用心脏磁共振(CMR)的细胞外体积分数(ECV)进行定量分析。本研究的目的旨在评估ECV%与左室失代偿和主动脉瓣狭窄介入治疗预后指标的相关性。本研究纳入分析了440名接受了CMR检测的重度主动脉瓣狭窄患者(平均年龄70±10岁,男性占59%),ECV%不随扫描仪制造商、磁场强度或T1映射序列的不同而改变。分析结果发现,ECV%与左室失代偿的指标

JACC:口服抗凝药不会降低血透房颤患者的栓塞风险

长期血透的患者出血的风险会增高,尽管口服抗凝药(OACs)可以降低房颤患者卒中风险,但是随机临床试验会将血透的患者排除在外。本荟萃分析的目的旨在评估OACs对接受血透治疗的房颤患者的影响。本研究纳入分析了16个符合标准的观察性研究(N=71877),其中只有2个研究为直接OACs。与未服用抗凝药物相比,apixaban和华法林与卒中和全身性栓塞风险的降低不相关,5mg的apixaban可以降低患者

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既往的基础研究已经证明吗啡可以减弱口服二磷酸腺苷受体阻滞剂的抗血小板作用,但是临床的结果却是相反。本研究的目的旨在评估吗啡与接受氯吡格雷治疗的非ST段抬高急性冠脉综合征(NSTEACS)缺血事件发生的相关性。本研究纳入分析了EARLY ACS临床试验中的5438名NSTEACS患者,终点事件是96h的死亡、心梗、反复缺血或血栓性抢救的复合事件,和30天死亡或心梗的复合事件。在接受氯吡格雷治疗的患者

JACC:经导管肺动脉瓣置换术后不良事件的研究

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盘点:JACC1月第三期研究一览

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由此可见,较高的PA和CRF与AF患者较低的CVD长期风险和全因死亡率相关。该发现支持AF患者常规PA和改善CRF的作用,以应对死亡率和发病率升高的风险。

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