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患者招募：以软组织肉瘤为主的晚期恶性实体瘤的TAEST16001临床试验

2020-04-14 MedSci MedSci原创

软组织肉瘤患者招募TAEST16001
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广东香雪精准医疗技术有限公司是广州市香雪制药股份有限公司子公司，前身是2012年成立的香雪生命科学研究中心，主要致力于研发具有我国自主知识产权的针对肿瘤的特异性T细胞过继免疫治疗的新方法，简称为TCR

广东香雪精准医疗技术有限公司是广州市香雪制药股份有限公司子公司，前身是2012年成立的香雪生命科学研究中心，主要致力于研发具有我国自主知识产权的针对肿瘤的特异性T细胞过继免疫治疗的新方法，简称为TCR-T免疫治疗技术。

另外，除了开发新一代基因抗肿瘤新药和T细胞基因治疗临床应用技术，香雪精准也是全球第二家开展高亲和性T细胞受体平台技术基因治疗技术的研发机构。此次公布的临床试验项目是针对于实体瘤治疗的国内首个TCR-T项目，对于国内免疫治疗领域是一次里程碑式的事件。

“TAEST16001治疗肿瘤抗原NY-ESO-1表达阳性（基因型为HLA-A*02:01）的以软组织肉瘤为主的晚期恶性实体瘤患者的开放、单臂、早期临床研究”现已开始招募受试者。

基本入选条件：

  1. 年龄18~70岁，包含18岁和70岁

  2. 病理学诊断明确的晚期恶性实体瘤，包括软组织肉瘤、原发性肝脏恶性肿瘤、卵巢恶性肿瘤、非小细胞肺癌（NSCLC）和乳腺癌等

  3. 经标准治疗失败或缺乏有效治疗

  4. 至少有1个可测量病灶

  5. 基因型为HLA-A*02:01且肿瘤抗原NY-ESO-1表达阳性

  6. 育龄女性或男性同意在研究期间及细胞治疗后1年内采取有效的避孕措施

  7. 育龄期女性血妊娠检查结果应为阴性

 

符合以上入选标准且有意向的患者请联系

邱助理 

18127997904

研究中心：中山大学肿瘤防治中心

张星主任（门诊周三、四、五上午--8：30-12：00）

翁德胜教授（门诊周二下午--14：30-17：30）

地址：广东省广州市越秀区东风东路651号

 

（以上招募信息已经过伦理委员会批准使用）

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  1. [GetPortalCommentsPageByObjectIdResponse(id=2051545, encodeId=43ce205154530, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Wed Aug 05 03:41:01 CST 2020, time=2020-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1738415, encodeId=9eed1e3841562, content=<a href='/topic/show?id=c3e01e0804d' target=_blank style='color:#2F92EE;'>#TAEST16001#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17080, encryptionId=c3e01e0804d, topicName=TAEST16001)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5aff34436240, createdName=陆成振, createdTime=Fri May 22 03:41:01 CST 2020, time=2020-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381888, encodeId=69a438188894, content=学习了很有用不錯, beContent=null, objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sun Apr 19 08:13:11 CST 2020, time=2020-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381801, encodeId=e6e9381801a4, content=很好的学习机会, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/12/cd30eefc465f70dc4dad89bd57479781.jpg, createdBy=02be2318568, createdName=一天没事干, createdTime=Fri Apr 17 08:07:26 CST 2020, time=2020-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1420456, encodeId=369514204561e, content=<a href='/topic/show?id=2221935219e' target=_blank style='color:#2F92EE;'>#软组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93521, encryptionId=2221935219e, topicName=软组织)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=52913579937, createdName=qilu_qi, createdTime=Thu Apr 16 13:41:01 CST 2020, time=2020-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1548549, encodeId=05b515485496d, content=<a href='/topic/show?id=6a4756229d9' target=_blank style='color:#2F92EE;'>#招募#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56229, encryptionId=6a4756229d9, topicName=招募)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=038c14086626, createdName=ms1260584454294838, createdTime=Thu Apr 16 13:41:01 CST 2020, time=2020-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381721, encodeId=2bb9381e21c5, content=很好的学习机会, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/12/cd30eefc465f70dc4dad89bd57479781.jpg, createdBy=02be2318568, createdName=一天没事干, createdTime=Wed Apr 15 08:31:57 CST 2020, time=2020-04-15, status=1, ipAttribution=)]
    2020-08-05 xiangyuzhou971

    #EST#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2051545, encodeId=43ce205154530, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Wed Aug 05 03:41:01 CST 2020, time=2020-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1738415, encodeId=9eed1e3841562, content=<a href='/topic/show?id=c3e01e0804d' target=_blank style='color:#2F92EE;'>#TAEST16001#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17080, encryptionId=c3e01e0804d, topicName=TAEST16001)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5aff34436240, createdName=陆成振, createdTime=Fri May 22 03:41:01 CST 2020, time=2020-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381888, encodeId=69a438188894, content=学习了很有用不錯, beContent=null, objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sun Apr 19 08:13:11 CST 2020, time=2020-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381801, encodeId=e6e9381801a4, content=很好的学习机会, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/12/cd30eefc465f70dc4dad89bd57479781.jpg, createdBy=02be2318568, createdName=一天没事干, createdTime=Fri Apr 17 08:07:26 CST 2020, time=2020-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1420456, encodeId=369514204561e, content=<a href='/topic/show?id=2221935219e' target=_blank style='color:#2F92EE;'>#软组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93521, encryptionId=2221935219e, topicName=软组织)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=52913579937, createdName=qilu_qi, createdTime=Thu Apr 16 13:41:01 CST 2020, time=2020-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1548549, encodeId=05b515485496d, content=<a href='/topic/show?id=6a4756229d9' target=_blank style='color:#2F92EE;'>#招募#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56229, encryptionId=6a4756229d9, topicName=招募)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=038c14086626, createdName=ms1260584454294838, createdTime=Thu Apr 16 13:41:01 CST 2020, time=2020-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381721, encodeId=2bb9381e21c5, content=很好的学习机会, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/12/cd30eefc465f70dc4dad89bd57479781.jpg, createdBy=02be2318568, createdName=一天没事干, createdTime=Wed Apr 15 08:31:57 CST 2020, time=2020-04-15, status=1, ipAttribution=)]
    2020-05-22 陆成振

    #TAEST16001#

    0

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    2020-04-19 飛歌

    学习了很有用不錯

    0

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    2020-04-17 一天没事干

    很好的学习机会

    0

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    2020-04-16 qilu_qi

    #软组织#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2051545, encodeId=43ce205154530, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Wed Aug 05 03:41:01 CST 2020, time=2020-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1738415, encodeId=9eed1e3841562, content=<a href='/topic/show?id=c3e01e0804d' target=_blank style='color:#2F92EE;'>#TAEST16001#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17080, encryptionId=c3e01e0804d, topicName=TAEST16001)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5aff34436240, createdName=陆成振, createdTime=Fri May 22 03:41:01 CST 2020, time=2020-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381888, encodeId=69a438188894, content=学习了很有用不錯, beContent=null, objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sun Apr 19 08:13:11 CST 2020, time=2020-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381801, encodeId=e6e9381801a4, content=很好的学习机会, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/12/cd30eefc465f70dc4dad89bd57479781.jpg, createdBy=02be2318568, createdName=一天没事干, createdTime=Fri Apr 17 08:07:26 CST 2020, time=2020-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1420456, encodeId=369514204561e, content=<a href='/topic/show?id=2221935219e' target=_blank style='color:#2F92EE;'>#软组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93521, encryptionId=2221935219e, topicName=软组织)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=52913579937, createdName=qilu_qi, createdTime=Thu Apr 16 13:41:01 CST 2020, time=2020-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1548549, encodeId=05b515485496d, content=<a href='/topic/show?id=6a4756229d9' target=_blank style='color:#2F92EE;'>#招募#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56229, encryptionId=6a4756229d9, topicName=招募)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=038c14086626, createdName=ms1260584454294838, createdTime=Thu Apr 16 13:41:01 CST 2020, time=2020-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381721, encodeId=2bb9381e21c5, content=很好的学习机会, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/12/cd30eefc465f70dc4dad89bd57479781.jpg, createdBy=02be2318568, createdName=一天没事干, createdTime=Wed Apr 15 08:31:57 CST 2020, time=2020-04-15, status=1, ipAttribution=)]
    2020-04-16 ms1260584454294838

    #招募#

    0

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    2020-04-15 一天没事干

    很好的学习机会

    0

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