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Expert Opin Drug Saf:抗甲状腺药物会否诱发急性精神障碍尚无定论

2013-08-08 wangrui cmt

近期BioPortfolio.com收载的一篇文章对有关应用抗甲状腺药物(ATDs)引起精神疾病的文献进行了回顾,并请专家对此进行了点评。ATDs临床用于甲状腺功能亢进的治疗,曾有少量报道称无精神病史的患者在应用ATDs后突发急性精神障碍。 作者认为,在应用因放射免疫鉴定法检测促甲状腺激素(TSH)和甲状腺激素的技术发明前,因使用ATD而诱发急性精神疾病的病例较为罕见,且大多数为多年前的报道

近期BioPortfolio.com收载的一篇文章对有关应用抗甲状腺药物(ATDs)引起精神疾病的文献进行了回顾,并请专家对此进行了点评。ATDs临床用于甲状腺功能亢进的治疗,曾有少量报道称无精神病史的患者在应用ATDs后突发急性精神障碍。

作者认为,在应用因放射免疫鉴定法检测促甲状腺激素(TSH)和甲状腺激素的技术发明前,因使用ATD而诱发急性精神疾病的病例较为罕见,且大多数为多年前的报道。这些病例都缺乏在精神障碍出现前、期间及出现后对血清甲状腺激素水平的描述,因此,无法排除从甲状腺功能亢进到甲状腺功能正常或功能减退的状况。此外,对于接受过特定抗精神病治疗的患者,所以很难将心理障碍的消失归功于ATD停药本身。

专家建议接受ATD治疗期间出现心理障碍的患者接受TSH、三碘甲状腺氨酶(FT3)及游离甲状腺素(FT4)水平的精确评估。先进的影像技术的应用可排除脑病相关的自身免疫性甲状腺疾病及其他可能引起这些心理障碍的脑部疾病。

Vita R, Mazzi V, Antonelli A, Benvenga S.Antithyroid medications and psychosis.Expert Opin Drug Saf. 2013 Jul 25. [Epub ahead of print]PMID:23883069

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    2018-05-02 olivia2008

    学习了!

    0

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    2013-09-22 爆笑小医
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    2014-06-14 feather89
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