Hepatol Res：胰岛素耐受增加了非酒精性肝病患者2型糖尿病患病风险

2018-04-11 MedSci MedSci原创

NASH患者有潜在葡萄糖耐受不良的风险。在NAFLD患者中，胰岛素抵抗是T2DM发病的最重要的危险因素。NAFLD患者需要适当的胰岛素抵抗治疗，以预防T2DM的发展。

研究目的：2型糖尿病(T2DM)是非酒精性脂肪肝(NAFLD)患者的主要并发症。这项回顾性研究的目的是为了确定NAFLD患者发生T2DM的危险因素。

研究方法：本研究纳入经肝穿证实的162例NAFLD患者，并接受75 g口服葡萄糖耐量测试。在这些患者中，分析89例经口服葡萄糖耐量试验证实的非2型糖尿病患者，以评估T2DM累积发生率。

研究结果：在162例患者中，45例患者(27.8%)经证实为糖尿病患者，68例患者(42.0%)被诊断为糖耐量受损，49例患者(30.2%)为正常糖耐量患者。与非酒精性脂肪性肝炎(NASH)患者相比，NAFL患者有正常葡萄糖耐受性的可能性更高。NASH组患者血清前、后负荷胰岛素水平显著升高。在89例非T2DM患者中，13例患者在随访5.2年期间新发T2DM。T2DM累积发病率在第5年末为8.8%，在第10年末为23.4%。多变量分析确定了评估-胰岛素抵抗稳态模型(≥3.85，危险比40.1，P = 0.033)为T2DM发生的独立危险因素。

研究结论：NASH患者有潜在葡萄糖耐受不良的风险。在NAFLD患者中，胰岛素抵抗是T2DM发病的最重要的危险因素。NAFLD患者需要适当的胰岛素抵抗治疗，以预防T2DM的发展。

原始出处：

Seko Y， Sumida Y， Tanaka S， et al. Insulin resistance increases the risk of incident type 2 diabetes mellitus in patients with non-alcoholic fatty liver disease. Hepatol Res， 2018， 48(3)： E42-E51. doi： 10.1111/hepr.12925.

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2019-03-27 baoya

#胰岛#

61 0
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2019-02-19 Tommy1958

#非酒精性#

72 0
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2018-07-19 huiwelcome

#酒精性#

65 0
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2018-12-22 chenzhuanggui

#肝病患者#

70 0
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2018-04-13 木头人513

#患病风险#

73 0
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2018-04-13 446798725_87912765

#酒精性肝病#

73 0
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2018-04-13 gwc384

#EPA#

83 0
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2018-04-12 大爰

学习了谢谢分享!!

1 0

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