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Hepatology:PPP1R3B基因变异与肝糖原和甘油三酯水平的关系

2018-06-26 MedSci MedSci原创

rs4841132的小等位基因促进了一种与肝损伤相关的肝糖原的中度增加。

研究背景:8号染色体上rs4240624的遗传变异与肝脏电脑断层扫描的衰减信号有关,这导致了肝脏脂肪的变化。最接近rs4240624的编码基因-PPP1R3B,编码了一种能够促进肝脏糖原合成的蛋白质。本研究的目的是确定与rs4240624相关的x射线衰减是否是由于肝糖原或肝甘油三酯含量(HTGC)的差异所致。

研究方法和结果:与rs4240624, rs4841132相关的一个序列变异在在达拉斯心脏研究(DHS),达拉斯肝脏研究和哥本哈根队列(n = 112428)中进行检测,其中有1539人患有非病毒性肝病。rs4841132的小A等位基因与肝脏x线衰减增加有关(n = 1572;P = 4 x 10(-5),但未使用HTGC (n = 2,674);P = 0.58)。Rs4841132-A与哥本哈根和DHS人群血清丙氨酸转氨酶(ALT)的中度升高有相关性(P值分别为3 x 10(-4))和0.004)),与肝病的优势比分别为1.13 (95% CI, 0.97-1.31)和1.23(1.01-1.51)。缺乏蛋白磷酸酶1调节亚基3B (PPP1R3B)的小鼠肝糖原不足,而HTGC含量没有改变。肝脏PPP1R3B的过表达引起肝糖原累积和血浆中ALT水平升高,但未改变HTGC水平。

研究结论:rs4841132的小等位基因促进了一种与肝损伤相关的肝糖原的中度增加。

原始出处:


Stender S, Smagris E, Lauridsen BK, et al. Relationship between genetic variation at PPP1R3B and levels of liver glycogen and triglyceride. Hepatology, 2018, 67(6), 2182-2195.

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    学习

    0

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  6. [GetPortalCommentsPageByObjectIdResponse(id=1685540, encodeId=d3f9168554018, content=<a href='/topic/show?id=69571454573' target=_blank style='color:#2F92EE;'>#PP1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14545, encryptionId=69571454573, topicName=PP1)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4f1028217817, createdName=ms9651749636653578, createdTime=Sun Feb 24 16:08:00 CST 2019, time=2019-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2007116, encodeId=15e7200e1164d, content=<a href='/topic/show?id=2f9e8133019' target=_blank style='color:#2F92EE;'>#肝糖原#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81330, encryptionId=2f9e8133019, topicName=肝糖原)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85df2500173, createdName=654699882_84926986, createdTime=Tue Mar 05 22:08:00 CST 2019, time=2019-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1791455, encodeId=9d9a1e91455e4, content=<a href='/topic/show?id=ac531458178' target=_blank style='color:#2F92EE;'>#PPP1R3B#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14581, encryptionId=ac531458178, topicName=PPP1R3B)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76d3356, createdName=tongyongming, createdTime=Mon Jan 28 13:08:00 CST 2019, time=2019-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328405, encodeId=b53132840591, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq08fBE4ne4yAYXulsHUXiafWXWEQ1kDkMHtT9loagc1nibPCrwjpESVuPO4De8QTeajAic31lDPfjuA/132, createdBy=92ce1931739, createdName=荒郊野树, createdTime=Sun Jul 01 09:26:25 CST 2018, time=2018-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1314168, encodeId=82b8131416890, content=<a href='/topic/show?id=b5e641e1279' target=_blank style='color:#2F92EE;'>#基因变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41712, encryptionId=b5e641e1279, topicName=基因变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=512d422, createdName=canlab, createdTime=Thu Jun 28 13:08:00 CST 2018, time=2018-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342494, encodeId=264a13424941c, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Thu Jun 28 13:08:00 CST 2018, time=2018-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1427147, encodeId=4c37142e14708, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Thu Jun 28 13:08:00 CST 2018, time=2018-06-28, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1685540, encodeId=d3f9168554018, content=<a href='/topic/show?id=69571454573' target=_blank style='color:#2F92EE;'>#PP1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14545, encryptionId=69571454573, topicName=PP1)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4f1028217817, createdName=ms9651749636653578, createdTime=Sun Feb 24 16:08:00 CST 2019, time=2019-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2007116, encodeId=15e7200e1164d, content=<a href='/topic/show?id=2f9e8133019' target=_blank style='color:#2F92EE;'>#肝糖原#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81330, encryptionId=2f9e8133019, topicName=肝糖原)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85df2500173, createdName=654699882_84926986, createdTime=Tue Mar 05 22:08:00 CST 2019, time=2019-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1791455, encodeId=9d9a1e91455e4, content=<a href='/topic/show?id=ac531458178' target=_blank style='color:#2F92EE;'>#PPP1R3B#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14581, encryptionId=ac531458178, topicName=PPP1R3B)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76d3356, createdName=tongyongming, createdTime=Mon Jan 28 13:08:00 CST 2019, time=2019-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328405, encodeId=b53132840591, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq08fBE4ne4yAYXulsHUXiafWXWEQ1kDkMHtT9loagc1nibPCrwjpESVuPO4De8QTeajAic31lDPfjuA/132, createdBy=92ce1931739, createdName=荒郊野树, createdTime=Sun Jul 01 09:26:25 CST 2018, time=2018-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1314168, encodeId=82b8131416890, content=<a href='/topic/show?id=b5e641e1279' target=_blank style='color:#2F92EE;'>#基因变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41712, encryptionId=b5e641e1279, topicName=基因变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=512d422, createdName=canlab, createdTime=Thu Jun 28 13:08:00 CST 2018, time=2018-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342494, encodeId=264a13424941c, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Thu Jun 28 13:08:00 CST 2018, time=2018-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1427147, encodeId=4c37142e14708, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Thu Jun 28 13:08:00 CST 2018, time=2018-06-28, status=1, ipAttribution=)]
    2018-06-28 gwc384
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