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JAMA Pediatr:布洛芬对持续性动脉导管未闭早产儿支气管肺发育不良风险的影响

2020-06-16 MedSci原创 MedSci原创

总体上,布洛芬在降低持续性动脉导管未闭早产儿支气管肺发育不良和死亡率方面无显著优势,但对于23-26周早产儿布洛芬治疗具有一定的效果。

早产儿持续性动脉导管未闭(PDA)导致呼吸系统疾病(支气管肺发育不良,BPD)和死亡率增加。近日研究人员考察了布洛芬对极早产PDA婴儿BPD发生率或死亡率的影响。
 
146名产后6至14天诊断为血流动力学显著性PDA的早产儿(胎龄[GA]23-30周)参与研究,随机接受布洛芬(初始剂量为10 mg/kg,24小时后服用5 mg/kg,48小时后服用5 mg/kg)或安慰剂。研究的主要终点为BPD或死亡,次要结果包括主要疾病和导管闭合率
 
参与患儿中,72名为非干预组,70名为布洛芬治疗组。在GA 27-30周的患儿中,使用布洛芬婴儿(11[34%])在随机分组后1周的PDA关闭率显著高于未干预的婴儿(2[7%]);然而,在GA23至26周患儿中,差异性降低(布洛芬组3[8%]vs未干预组1[2%])。两组患儿出院前导管闭合率(布洛芬组62[89%] vs未干预组59[82%])和器械闭合率(布洛芬组2[3%]vs未干预组4[6%])无显著差异。在BPD发生率或死亡方面,组间差异不显著(未干预:44%;布洛芬:50%)。
 
总体上,布洛芬在降低持续性动脉导管未闭早产儿支气管肺发育不良和死亡率方面无显著优势,但对于23-26周早产儿布洛芬治疗具有一定的效果。
 
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    2021-04-21 feather89
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  5. 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target=_blank style='color:#2F92EE;'>#支气管肺发育不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57160, encryptionId=33615e160c1, topicName=支气管肺发育不良)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=598a379, createdName=photoman, createdTime=Thu Jun 18 09:35:34 CST 2020, time=2020-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1522280, encodeId=27971522280e7, content=<a href='/topic/show?id=ed183323e02' target=_blank style='color:#2F92EE;'>#动脉导管未闭#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33237, encryptionId=ed183323e02, topicName=动脉导管未闭)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=40e811444670, createdName=shizhenshan, createdTime=Thu Jun 18 09:35:34 CST 2020, time=2020-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1567998, encodeId=a37c156e99862, content=<a href='/topic/show?id=7a833e94079' target=_blank style='color:#2F92EE;'>#发育不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37940, encryptionId=7a833e94079, topicName=发育不良)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30b515313716, createdName=villahu, createdTime=Thu Jun 18 09:35:34 CST 2020, time=2020-06-18, status=1, ipAttribution=)]
    2020-08-10 🍃叶子🍃

    学习了

    0

  6. 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  7. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1567998, encodeId=a37c156e99862, content=<a href='/topic/show?id=7a833e94079' target=_blank style='color:#2F92EE;'>#发育不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37940, encryptionId=7a833e94079, topicName=发育不良)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30b515313716, createdName=villahu, createdTime=Thu Jun 18 09:35:34 CST 2020, time=2020-06-18, status=1, ipAttribution=)]
    2020-06-18 neurowu
  8. 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