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JAMA Cardiol:核磁检查发现的隐匿性心梗比临床确诊的心梗多

2018-10-19 xujing 中国循环杂志

有一类心梗,没有临床症状,只有在客观检测是才能识别,这类隐匿性心梗的预后与临床确诊的心梗以及无心梗的正常人相比,其长期预后如何?

有一类心梗,没有临床症状,只有在客观检测是才能识别,这类隐匿性心梗的预后与临床确诊的心梗以及无心梗的正常人相比,其长期预后如何?

JAMA 心脏病学子刊上发表的一项研究发现,通过心脏磁共振成像检测出的隐匿性心梗的长期预后与临床诊断的心梗者相当。

研究纳入了935名受试者,在基线时,隐匿性心梗(17%)比临床诊断的心梗(10%)更多见。两者在男性中比女性更常见。

传统的血管危险因素在隐匿性心梗和临床诊断的心梗患者中更为普遍。临床诊断心梗更多表现为危险因素控制,比如具有更低吸烟率、较低的胆固醇水平和更多的基于指南的医疗处方。

隐匿性心梗的冠状动脉钙化积分介于临床诊断的心梗和无心梗之间,同样,隐匿性心梗(60%)的左室射血分数介于临床诊断的心梗(53%)和无心梗(63%)之间。

心脏磁共振成像检测出了隐匿性心梗的梗死面积明显小于临床诊断的心梗(左心室:4% vs 9.6%)。

研究者发现,隐匿性心梗的短期内无心梗者的死亡率相似,但在5年以后,隐匿性心梗的死亡率高于无心梗者,逐步与临床诊断的心梗持平。

随访3年时,隐匿性心梗和无心梗死亡率相似(3%),低于临床诊断的心梗的死亡率(9%)。

到第10年,隐匿性心梗和临床诊断的心梗死亡率(分别为49%和51%)无差异,均显着高于无心梗者(30%)。

男性、糖尿病患者和70岁以下的人群死于隐匿性心梗的风险较高。

研究者分析,隐匿性心梗和临床诊断心梗的死亡率曲线的渐进收敛可能有2种可能的机制:

首先,与临床诊断的心梗相比,隐匿性心梗可能代表了一种不同的冠心病表型,具有更多小血管受累和心房颤动。

其次,由于在基线时心外膜斑块负担低于临床诊断的心梗,以至于隐匿性心梗的不良事件发生较临床诊断的心梗延后。

另外,随着时间的推移,额外的隐匿性心梗发生加速了该组的死亡率也是合理的。

与死亡率不同,隐匿性心梗发生非致命性心梗和心力衰竭的发病率在短期内增加。

在对年龄、性别和糖尿病进行调整后,隐匿性心梗的死亡风险和MACE与临床确诊的心梗相当。

原始出处:Tushar Acharya, MD; Thor Aspelund, PhD; Torfi F. Jonasson, MD, PhD; et al. Association of Unrecognized Myocardial Infarction With Long-term Outcomes in Community-Dwelling Older Adults: The ICELAND MI Study. JAMA Cardiol. October 10, 2018

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    2018-11-23 13718711b3m

    非常实用的学习资料,值得借鉴的临床经验,学习了,获益匪浅,谢谢分享!

    0

  4. 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createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Fri Oct 19 01:17:23 CST 2018, time=2018-10-19, status=1, ipAttribution=)]
    2018-10-29 13718711b3m

    值得借鉴的临床经验,学习了,实用性非常强,涨知识,获益匪浅,感谢分享,谢谢!

    0

  5. 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    2018-10-19 smartxiuxiu

    0

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createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Fri Oct 19 01:17:23 CST 2018, time=2018-10-19, status=1, ipAttribution=)]
    2018-10-19 天地飞扬

    了解一下,谢谢分享!

    0

  8. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Fri Oct 19 12:51:56 CST 2018, time=2018-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=349805, encodeId=a6c93498056a, content=了解一下,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Fri Oct 19 08:29:06 CST 2018, time=2018-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=349801, encodeId=8323349801f0, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Fri Oct 19 08:03:56 CST 2018, time=2018-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=349790, encodeId=73f4349e90f8, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Fri Oct 19 07:09:42 CST 2018, time=2018-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=349773, encodeId=8fcf349e73a1, content=学习了很有用不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Fri Oct 19 01:17:23 CST 2018, time=2018-10-19, status=1, ipAttribution=)]
    2018-10-19 orangesking

    0

  9. 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createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Fri Oct 19 01:17:23 CST 2018, time=2018-10-19, status=1, ipAttribution=)]
    2018-10-19 明月清辉

    谢谢分享,学习了

    0

  10. 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    2018-10-19 飛歌

    学习了很有用不错

    0

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多参数的核磁共振成像(mpMRI)在前列腺癌(PCa)中的使用频率正在增加。最近的研究鉴定了不同的PCa分子亚类,且具有复发性基因组变异特征。然而,在前列腺癌中的分子变异与mpMRI相关的特性仍旧是未知的。基于该背景,最近,有研究人员调查了前列腺癌中复发性分子变异与mpMRI特性的相关关系。研究中,研究恩怨62个大于0.5厘米的前列腺癌瘤进行了手术前的mpMRI,并对囊肿进行了ERG重排、PTEN

就医贴士:做核磁共振前如果不懂这些,真挺危险的!

这是某医院的核磁共振室,我们可以看到这台核磁共振仪上吸着一把轮椅。 咋回事呢?原来,是有患者家属不听劝告,在家人做完核磁共振检查之后把轮椅推进了检查室,由于核磁共振仪当时处于待机状态,而即使是处于待机状态核磁共振仪仍然是有磁性的,所以金属制造的轮椅立马就被吸到了仪器上。

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