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JAMA Intern Med:鱼类消费与主要心血管事件风险

2021-03-09 MedSci原创 MedSci原创

对于存在基础心血管疾病的患者,每周摄入至少175克富含ω-3脂肪酸的鱼类可降低心肌梗死、中风、充血性心力衰竭或猝死等主要心血管事件风险,而对于一般人群,鱼类摄入量不会影响CVD事件风险

食用鱼类以及大量的含长链ω-3脂肪酸保健食品被认为与降低血管疾病(CVD)风险相关,但多数对照实验不支持常规鱼油制品对降低CVD事件风险有益。目前,仅高纯度鱼油制剂Vascepa(icosapent ethyl)被FDA批准用于甘油三酯水平升高且伴有至少2种其他心血管疾病危险因素的心血管疾病或糖尿病患者。
近日,研究人员考察了食用鱼类对心血管疾病风险或死亡率的影响,着重于比较有心血管疾病个体和无心血管疾病个体之间的差异。
研究人员收集了来自21个国家,191558名参与者数据,其中139827人无基础CVD,使用食物消费频率问卷考察鱼类消费情况。研究的主要终点为死亡率和主要CVD事件,包括心肌梗死、中风、充血性心力衰竭或猝死。
 
参与者平均年龄54.1岁,男性占47.9%,平均随访9.1年。总人群中,与少量或不摄入鱼类(≤50g/月)人群相比,鱼类摄入量在350g/周或更高人群的主要CVD事件风险(HR:0.95)或总死亡率(HR,0.96;0.88-1.05)未见显著变化。相比之下,在存在基础心血管疾病患者中,与鱼类摄入量低于50g/月人群相比,摄入量在175g/周及以上人群的主要CVD事件风险(HR=0.84)和总死亡率(HR=0.82)降低,摄入量在350 g/周或更高时,风险没有进一步明显下降。摄入ω-3脂肪酸含量较高鱼类与CVD事件风险较低密切相关(摄入量每增加5g的HR=0.94),而其他鱼类的影响不显著。
研究认为,对于存在基础心血管疾病的患者,每周摄入至少175克富含ω-3脂肪酸的鱼类可降低心肌梗死、中风、充血性心力衰竭或猝死等主要心血管事件风险,而对于一般人群,鱼类摄入量不会影响CVD事件风险
 
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1643734, encodeId=df4c1643e34f7, content=<a href='/topic/show?id=6236895092b' target=_blank style='color:#2F92EE;'>#血管事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89509, encryptionId=6236895092b, topicName=血管事件)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f99523187183, createdName=hukaixun, createdTime=Fri Dec 03 08:17:43 CST 2021, time=2021-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1287703, encodeId=0606128e703b0, content=<a href='/topic/show?id=3c3d51e4459' target=_blank style='color:#2F92EE;'>#心血管事件风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51744, encryptionId=3c3d51e4459, topicName=心血管事件风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Thu Mar 11 11:17:43 CST 2021, time=2021-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1552800, encodeId=374c15528001c, content=<a href='/topic/show?id=5ec6232e1bd' target=_blank style='color:#2F92EE;'>#主要心血管事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23271, encryptionId=5ec6232e1bd, topicName=主要心血管事件)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=058f14296236, createdName=jiyangfei, createdTime=Thu Mar 11 11:17:43 CST 2021, time=2021-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610953, encodeId=1dea1610953f1, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Thu Mar 11 11:17:43 CST 2021, time=2021-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=947082, encodeId=68c594e082af, content=心血管事件风险, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210110/e6124a4b19bc40ce8afaae096d21126b/dd778ac260c9416eb87e7d08139507f5.jpg, createdBy=4d2f5079605, createdName=科研科研科研, createdTime=Wed Mar 10 13:04:26 CST 2021, time=2021-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=947007, encodeId=30cd94e007ab, content=a亚麻酸得吃起来, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47815461632, createdName=ms7000001724057117, createdTime=Wed Mar 10 09:00:27 CST 2021, time=2021-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036502, encodeId=07b81036502bb, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Tue Mar 09 23:17:43 CST 2021, time=2021-03-09, status=1, ipAttribution=)]
    2021-03-10 科研科研科研

    心血管事件风险

    0

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    2021-03-10 ms7000001724057117

    a亚麻酸得吃起来

    0

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    2021-03-09 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

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