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CA-Cancer J Clin:肝癌的死亡率在不断增长!

2017-06-12 秋海 来宝网

据美国癌症学会最新统计消息披露,现今在美国,肝癌的死亡率是二十世纪八十年代的两倍,并且增长速度比其他任何一个癌症都快。

据美国癌症学会最新统计消息披露,现今在美国,肝癌的死亡率是二十世纪八十年代的两倍,并且增长速度比其他任何一个癌症都快。

该发现已发表于6月7日A Cancer Journal for Clinicians上。

自2009年至2013年,肝癌的每年平均发病率是十万分之7.7,死亡率是十万分之6.3.

研究人员注意到,该数字在过去几年在不断增加,自从1975年的发生率及自从1980年的死亡率。2009-2013年的肝癌死亡率是二十世纪八十年代的2倍。

更显着的是,男性的发生率和死亡率是女性的2-3倍。

乔治亚洲亚特山大美国癌症协会、癌症检测研究所的策略总监Islami博士评论说,在近几年有记录过生存率有改善,但肝癌的预后仍然不乐观,患者被诊断后生存时间达5年以上的仅有20%。

大部分肝癌的常见组织学类型是原发性肝癌(HCC),在美国该比例超过70%。

估计,美国今年将会增加41000个肝癌新病例,且会出现29000个死亡病例。

可改变的风险因素

研究人员指出,在美国有超过60%的肝癌患者是受到可改变的风险因素引起的。例如,在医保人员中进行统计,32%的肝癌患者是因代谢障碍引起的,包括肥胖。小部分是因丙肝病毒感染(21%),酗酒(13%)以及抽烟(9%)。

据最新的数据分析,因乙肝病毒感染引起的患者比例仅为4%。

“由性别、年龄、国家及种族/宗教组成的风险因素差异性,占据了大部分肝癌发生的变数,”Islami医生与他的同事们观察到。例如,因为西班牙人住在德克萨斯州,该地多为墨西哥的后代,这里的死亡率比住在佛罗里达州的高,佛罗里达州多为古巴或波多黎各的后代。

研究人员推测,西班牙人在墨西哥的死亡率高反映了丙肝病毒流行率、超重现象以及非酒精肥胖肝病的流行率高。

研究人员观察到,丙肝感染的流行率相对较高,2.6%,在婴儿潮时,80%的肝癌发病是由丙肝感染引起。

研究人员强调,“总体来看,在2000-2011年间,由丙肝引起的肝癌,在白人中占17%,西班牙人占21%,亚洲占30%,以及黑人占36%。”

相比之下,在美国,乙肝感染引起的肝癌的比例占肝癌总数低于5%。

研究人员指出,由肥胖引发的肝癌发病率近几年均持续高于由种族及宗教引起的的。

“在大部分案例中,在每个种族/宗教人群中,不同类型的肥胖相对应不同的肝癌死亡率,”作者注意到。糖尿病同样亦能增加肝癌的风险,不管是男性还是女性。

非酒精肥胖的肝病患者恶化为肝癌的风险均一致,且在2011-2012年间,非酒精肝基本的发生率提高了31%。

“酒精消耗可增加肝癌风险的概率大概为10%每杯每天(如,若某人每天喝8杯酒则增加3倍风险),”研究者指出,以及“吸烟可增加肝癌风险接近50%。”

该研究的作者指出,许多肝癌可通过改变不同的风险因素进而抑制其恶化。

“在美国,肝癌所带来的负担是非常巨大的,且预计会在未来几十年仍在不断增长,”Islami博士与他的同事说道。

“然而,大部分的癌症是可预防的,干预措施用来治疗肝癌不断增长的风险及降低种族/宗教差异,应该将现有的知识应用于预防、早期监测及治疗上。”

原始出处:

Farhad Islami, Kimberly D. Miller, et al. Disparities in liver cancer occurrence in the United States by race/ethnicity and state. CA: A Cancer Journal for Clinicians First published: 6 June 2017  DOI: 10.3322/caac.21402

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    2017-06-15 日月生辉

    值得学习与交流,全面认清肝癌特点!

    0

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    2017-06-14 ylzr123

    好文,值得点赞!认真学习,应用于实践!谢谢分享给广大同好!

    0

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    2017-06-13 1dde3188m00(暂无匿称)

    我国数据是多少呢?随着我国乙肝患者的逐步降低,相信10-20年后我国原发性肝癌发病率会降低

    0

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    2017-06-12 蔬菜

    非常棒??,学习了,要是能有中国的数据对比就好了

    0

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    2017-06-12 139****5926

    好文章学习了

    0

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    2017-06-12 中医痴

    很不错,学习了,谢谢分享!

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1780519, encodeId=9b211e8051959, content=<a href='/topic/show?id=dbc6392906' target=_blank style='color:#2F92EE;'>#CA-Cancer#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3929, encryptionId=dbc6392906, topicName=CA-Cancer)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/xkicoVBAnV4HxvdCqC1viaW8wdLQdN9hVP9icgqqDsxC6UVPjfhogdfc2iaU1xNUMVlFl5QicicWrjWQBTsVye5ngOQQ/132, createdBy=f92f2500185, createdName=ms7405317358118777, createdTime=Sat Oct 14 21:01:00 CST 2017, time=2017-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210941, encodeId=e6a7210941af, content=值得学习与交流,全面认清肝癌特点!, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib260FNcic8ThYQJjaU2fLIb1yNqibkbdJs7gVIDr9xJyYeiapArSMjn3W61bPJtpIazSdAxRaFEOKYgfQjX4achN2d/0, createdBy=68472058812, createdName=日月生辉, createdTime=Thu Jun 15 06:59:58 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210526, encodeId=aa77210526d8, content=好文,值得点赞!认真学习,应用于实践!谢谢分享给广大同好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Wed Jun 14 07:49:43 CST 2017, time=2017-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210148, encodeId=951e2101483e, content=我国数据是多少呢?随着我国乙肝患者的逐步降低,相信10-20年后我国原发性肝癌发病率会降低, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7871658517, createdName=1dde3188m00(暂无匿称), createdTime=Tue Jun 13 08:52:51 CST 2017, time=2017-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209881, encodeId=f125209881cf, content=非常棒??,学习了,要是能有中国的数据对比就好了, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aadd1680584, createdName=蔬菜, createdTime=Mon Jun 12 16:26:08 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209867, encodeId=cdf020986e23, content=好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Mon Jun 12 15:01:20 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209850, encodeId=d581209850dd, content=很不错,学习了,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Mon Jun 12 14:12:36 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209835, encodeId=6e74209835ce, content=学习了,值得分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Mon Jun 12 13:14:47 CST 2017, time=2017-06-12, status=1, ipAttribution=)]
    2017-06-12 1ddf0692m34(暂无匿称)

    学习了,值得分享

    0

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