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J Hypertens:老年患者不同降压药物降低痴呆风险分析!

2017-05-25 xing.T MedSci原创

由此可见,老年人中使用CCBs和ARBs与老年痴呆症的风险降低独立相关。

使用降压药物(AHM)与老年痴呆症的风险降低存在潜在相关性。钙通道阻滞剂(CCBs)和血管紧张素受体阻滞剂(ARBs)提示有更明显的保护作用。近日,高血压领域权威杂志Journal of Hypertension上发表了一篇研究文章,研究人员旨在研究中老年人不同类别的AHM和老年痴呆症之间的相关性。

研究人员将服用AHN的社区居住的老年人纳入通过强化血管护理来预防痴呆的随机对照试验进行研究。研究人员比较了服用不同AHM类型(单一或联合治疗)参与者的痴呆发生率。

在基线时,1951名参与者(55.3%)服用了AHM [平均年龄为74.4岁(SD为2.5);平均收缩压为156.4mmHg,(SD为21.5)]。总的来说,986名参与者(50.5%)使用了β-受体阻滞剂,798名参与者(40.9%)服用了利尿剂,623名参与者(31.9%)服用了血管紧张素转换酶抑制剂,522名参与者(26.8%)服用了CCBs,402名参与者(20.6%)服用了ARBs。经过6.7年(四分位距为6.0-7.3)的随访,136名参与者(7%)发生痴呆。使用CCBs [风险比为0.56,95%可信区间(95% CI)为0.36-0.87]和ARBs(风险比为0.60,95%CI为0.37-0.98)与发生痴呆症的风险降低独立相关。CCB与痴呆之间的相关性在没有心血管疾病病史(风险比为0.38,95%CI为0.18-0.81)和未控制的高血压(风险比为0.26,95%CI为0.11-0.61)的参与者中最为明显。在使用CCB或ARB的参与者中,收缩压并不显着降低。

由此可见,老年人中使用CCBs和ARBs与老年痴呆症的风险降低独立相关。

原始出处:

van Middelaar, Tessa.et al. Lower dementia risk with different classes of antihypertensive medication in older patients.Journal of Hypertension. 2017. http://journals.lww.com/jhypertension/Abstract/publishahead/Lower_dementia_risk_with_different_classes_of.97719.aspx

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    2018-04-09 feather89
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    2017-05-26 ylzr123

    好文,值得点赞,更值得收藏!慢慢领会学习的。给点个赞!

    0

  6. 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    2017-05-26 baihao215

    精准降压慢慢长路

    0

  7. 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authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo4D3YwOicNvmKe4SFfice8XbYUeaXKmPywR8IyYoO4s37MFHKiaicopGGjoicc3xicLul5jW1Oic3AMviacjg/0, createdBy=3ce42058518, createdName=皇家骑士团团尾, createdTime=Thu May 25 15:36:28 CST 2017, time=2017-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202366, encodeId=c6022023665f, content=学习啦谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Thu May 25 09:34:17 CST 2017, time=2017-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202354, encodeId=f8f120235495, content=学习,感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Thu May 25 08:56:32 CST 2017, time=2017-05-25, status=1, ipAttribution=)]
    2017-05-26 meiliwuxian

    药不能乱吃啊

    0

  8. 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likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Thu May 25 08:56:32 CST 2017, time=2017-05-25, status=1, ipAttribution=)]
    2017-05-25 皇家骑士团团尾

    这个特别适用!!!

    0

  9. 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likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Thu May 25 08:56:32 CST 2017, time=2017-05-25, status=1, ipAttribution=)]
    2017-05-25 tanxingdoctor

    学习啦谢谢分享

    0

  10. 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    2017-05-25 执着追梦

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