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Clinical Nutrition:耐消化淀粉组合物对中老年成年人肠道微生物群有重要影响

2018-06-07 MedSci MedSci原创

老年人的饮食经常缺乏抗消化性淀粉(RS),而这是被认为导致肠道微生物群失调的主要原因,并且有可能导致肠结肠细胞恶变。

背景
老年人的饮食经常缺乏抗消化性淀粉(RS),而这是被认为导致肠道微生物群失调的主要原因,并且有可能导致肠结肠细胞恶变。

目的
本项研究的主要目的是评估老年人(70周岁以上)与中年人(30-50岁)服用MSPrebiotic(一种抗消化性淀粉食物)与服用安慰剂3个月后肠道微生物群组成的变化。次要目标包括患者大便短链脂肪酸(SCFA)和炎症标志物。

设计
这是一项前瞻性,安慰剂对照,随机双盲研究。粪便样本在随机分组后0,6,10和14周进行收集。并使用16S rRNA测序对患者大变样本完成微生物组学分析。使用气相色谱法进行粪便的SCFA分析。

结果
有42名老年人和42 中年人参与随机接受安慰剂或MSPrebiotic  实验研究。结果显示在老年患者中有显着的高变形菌(大肠杆菌/志贺氏菌)(P <0.001),与安慰剂相比,老年人和中年人中的双歧杆菌显着增加(p = 0.047和0.006)。服用MSPrebiotic 的老年人的大便中短链脂肪酸丁酸水平显着增加。

结论
该研究的数据表明,MSPrebiotic  是满足标准的益生元食物,并且可以刺激内源性双歧杆菌的丰度增加,MSPrebiotic的使用也使得老年人实验组肠道变形菌菌群的恢复。


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    2018-06-15 wxl882001

    学习一下

    0

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    2018-06-09 zll0628
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    2018-06-08 易水河

    学习学习了

    0

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    2018-06-08 wxl882001

    学习一下

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