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Eur Urol Focus:F-18氟脱氧葡萄糖正电子发射断层扫描与计算机断层扫描对高风险阴茎癌患者的盆腔及远期分期有较高的诊断价值

2021-03-20 AlexYang MedSci原创

对于有盆腔转移的阴茎癌患者,建议进行多模式治疗,但盆腔淋巴结转移往往只在手术切除时发现。早期选择多模式治疗需要可靠的无创分期。

对于有盆腔转移的阴茎癌患者,建议进行多模式治疗,但盆腔淋巴结转移往往只在手术切除时发现。早期选择多模式治疗需要可靠的无创分期

最近,有研究人员评估了18F-氟脱氧葡萄糖正电子发射断层扫描与计算机断层扫描(FDG-PET/CT)对高风险阴茎癌患者的盆腔淋巴结和远处转移分期的诊断价值

研究进行的时间为2006年至2016年,共有61名患者符合纳入标准。对于盆腔结节的分期,FDG-PET/CT的敏感性为85%(特异性75%,阴性预测值[NPV]90%,阳性预测值[PPV]65%)。对于远处转移的检测,FDG-PET/CT的PPV为93%。研究结果受限于回顾性设计和缺乏与单独CT扫描的直接比较。

最后,研究人员指出,FDG-PET/CT对高风险阴茎癌患者的盆腔淋巴结的分期具有高灵敏度和高NPV。对远处转移的检测也有较高的PPV。因此,FDG-PET/CT可以促使盆腔转移患者多模式治疗的早期选择,有助于避免远处转移患者的无效治疗。

原始出处:

Sarah R Ottenhof , Rosa S Djajadiningrat , Michelle W J Versleijen et al. F-18 Fluorodeoxyglucose Positron Emission Tomography with Computed Tomography Has High Diagnostic Value for Pelvic and Distant Staging in Patients with High-risk Penile Carcinoma. Eur Urol Focus. Mar 2021

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    2021-03-22 仁医06
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