NRR：白藜芦醇治疗神经退行性疾病的潜力？

白藜芦醇作为一种天然的酚化合物，有预防心血管疾病和抗肿瘤，以及神经保护作用。

胚胎神经干细胞存在于中枢神经系统中，可分化为神经元和胶质细胞。有研究以胚胎神经干细胞移植诱导神经退行性疾病动物模型丢失神经元再生。

白藜芦醇是否对胚胎神经干细胞产生影响，从而提高其用于治疗神经退行性疾病的能力呢？

发表于2013年2月第6期《中国神经再生研究（英文版）》(Neural Regeneration Research)杂志的一项研究”Effects of resveratrol on hydrogen peroxide-induced oxidative stress in embryonic neural stem cells”表明，白藜芦醇提高抗氧化酶活性的作用可减轻胚胎神经干细胞受到的氧化应激性损害。

 白藜芦醇拮抗胚胎神经干细胞过氧化氢神经损害和氧化损伤的实验流程

实验旨在观察白藜芦醇拮抗过氧化氢神经损害和氧化损伤的作用。过氧化氢可提高胚胎神经干细胞过氧化氢酶和谷胱甘肽过氧化物酶、一氧化氮合酶活性，以及一氧化氮水平，但对超氧化物歧化酶活性无明显影响。白藜芦醇可拮抗过氧化氢诱导的胚胎神经干细胞一氧化氮合酶和一氧化氮水平上升。白藜芦醇可减轻诱导的胚胎神经干细胞核DNA和线粒体DNA损害作用。

研究为白藜芦醇对抗氧化损伤，间接提高干细胞移植治疗神经退行性疾病效果提供了实验证据。

与白藜芦醇相关的拓展阅读：

• 白藜芦醇可改善败血症诱导的急性肾损伤
• EBM：饮食对生长追赶期骨质的影响及白藜芦醇的干预作用
• PNAS：抗氧化剂白藜芦醇等或成为改进的抗癌药物
• Kidney：白藜芦醇可改善败血症诱导的急性肾损伤
• 白藜芦醇抑制乳腺癌细胞增殖（附点评）
更多信息请点击：有关白藜芦醇更多资讯

DOI: 10.3969/j.issn.1673-5374.2013.06.001

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Effects of resveratrol on hydrogen peroxide-induced oxidative stress in embryonic neural stem cells

Sibel Konyalioglu, Guliz Armagan, Ayfer Yalcin, Cigdem Atalayin, Taner Dagci.

Resveratrol, a natural phenolic compound, has been shown to prevent cardiovascular diseases and cancer and exhibit neuroprotective effects. In this study, we examined the neuroprotective and antioxidant effects of resveratrol against hydrogen peroxide in embryonic neural stem cells. Hydrogen peroxide treatment alone increased catalase and glutathione peroxidase activities but did not change superoxide dismutase levels compared with hydrogen peroxide + resveratrol treatment. Nitric oxide synthase activity and concomitant nitric oxide levels increased in response to hydrogen peroxide treatment. Conversely, resveratrol treatment decreased nitric oxide synthase activity and nitric oxide levels. Resveratrol also attenuated hydrogen peroxide-induced nuclear or mitochondrial DNA damage. We propose that resveratrol may be a promising agent for protecting embryonic neural stem cells because of its potential to decrease oxidative stress by inducing higher activity of antioxidant enzymes, decreasing nitric oxide production and nitric oxide synthase activity, and alleviating both nuclear and mitochondrial DNA damage.