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AAN2013:抑郁可升高卒中患者死亡风险

2013-01-14 AAN2013 CMT 高晓方 编译

Table. Adjusted Risk for All-Cause and Stroke Mortality With Stroke and Depression vs Neither Condition   即将于第65届美国神经病学学会(AAN2013)年会公布的一项报告表明,同时伴抑郁和卒中的患者全因死亡风险升高;治疗抑郁有可能改善此类患者的临床转归。   此项研究从美国健康和营养


Table. Adjusted Risk for All-Cause and Stroke Mortality With Stroke and Depression vs Neither Condition

  即将于第65届美国神经病学学会(AAN2013)年会公布的一项报告表明,同时伴抑郁和卒中的患者全因死亡风险升高;治疗抑郁有可能改善此类患者的临床转归。

  此项研究从美国健康和营养调查I(NHANES I)流行病学随访研究中纳入10,550例受试者。受试者年龄为25~75岁,随访时间为21年。发生卒中但无抑郁、同时伴卒中和抑郁、无卒中和抑郁、伴抑郁但无卒中的受试者分别为73、48、8138和2291例。以流行病调查中心抑郁量表评分≥16分定义抑郁。对结果进行人口统计学(年龄你给、性别和种族)和社会经济(教育程度、收入水平和婚姻状况)因素校正。

  结果显示,在未校正分析中,同时伴卒中和抑郁的受试者全因死亡风险升高4倍以上。对社会人口统计因素进行校正之后,上述受试者的全因死亡风险仍升高近3倍(危险比[HR] 2.86)。与无卒中和抑郁的受试者相比,同时伴上述两种疾病的受试者卒中死亡风险亦升高近4倍(HR 3.69)。行为改变可能为抑郁与卒中患者死亡率升高的联系机制。

  原文阅读:Depression Linked to Increased Stroke Mortality




    

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